HomoloGene

HomoloGene:1609. Gene conserved in Eukaryota

Genes Genes identified as putative homologs of one another during the construction of HomoloGene.		Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	HMGCS1, H.sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)		NP_001091742.1 520 aa
	HMGCS1, P.troglodytes 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)		XP_003310783.1 520 aa
	HMGCS1, M.mulatta 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)		XP_002804403.1 520 aa
	HMGCS1, C.lupus 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)		XP_005619400.1 520 aa
	HMGCS1, B.taurus HMGCS1 protein-like		NP_001193507.1 520 aa
	Hmgcs1, M.musculus 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1		NP_666054.2 520 aa
	Hmgcs1, R.norvegicus 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)		NP_058964.1 520 aa
	HMGCS1, G.gallus 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)		NP_990742.1 522 aa
	hmgcs1, X.tropicalis 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)		NP_001120172.1 520 aa
	hmgcs1, D.rerio 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)		NP_957379.1 508 aa
	Hmgs, D.melanogaster HMG Coenzyme A synthase		NP_725570.1 465 aa
	AgaP_AGAP005847, A.gambiae AgaP_AGAP005847		XP_315872.3 470 aa
	ERG13, S.cerevisiae ERG13		NP_013580.1 491 aa
	KLLA0D10505g, K.lactis KLLA0D10505g		XP_453529.2 464 aa
	AGOS_ADL356C, E.gossypii AGOS_ADL356C		NP_983739.1 464 aa
	hcs1, S.pombe hcs1		NP_593859.1 447 aa
	MGG_01026, M.oryzae MGG_01026		XP_003717917.1 456 aa
	NCU03922, N.crassa NCU03922		XP_957561.1 454 aa
	MVA1, A.thaliana MVA1		NP_192919.1 461 aa
	Os03g0118800, O.sativa Os03g0118800		NP_001048774.1 463 aa
	Os08g0544900, O.sativa Os08g0544900		NP_001062410.1 467 aa
	Os09g0521400, O.sativa Os09g0521400		NP_001063706.1 476 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
The Arabidopsis FLAKY POLLEN1 gene encodes a 3-hydroxy-3-methylglutaryl-coenzyme A synthase required for development of tapetum-specific organelles and fertility of pollen grains. Ishiguro S, et al. Plant Cell Physiol 51, 896-911 (2010).
Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats. Einbond LS, et al. Fundam Clin Pharmacol 23, 311-21 (2009).
Proteomic and transcriptomic analysis for streptozotocin-induced diabetic rat pancreas in response to fungal polysaccharide treatments. Kim SW, et al. Proteomics 8, 2344-61 (2008).
The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. Wang Y, et al. J Proteome Res 7, 1606-14 (2008).
Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity. Wu L, et al. Org Lett 9, 3877-80 (2007).
Correlation between protein accumulation profiles and conventional toxicological findings using a model antiandrogenic compound, flutamide. Friry-Santini C, et al. Toxicol Sci 97, 81-93 (2007).
Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins. Morikawa S, et al. J Atheroscler Thromb 12, 121-31 (2005).
Alpha-tocopherol affects androgen metabolism in male rat. Barella L, et al. Ann N Y Acad Sci 1031, 334-6 (2004).
Regulation of luteinizing hormone/chorionic gonadotropin receptor messenger ribonucleic acid expression in the rat ovary: relationship to cholesterol metabolism. Wang L & Menon KM. Endocrinology 146, 423-31 (2005).
Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Tomoda H, et al. Biochim Biophys Acta 1636, 22-8 (2004).
See all (68)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLN02577 (PLN02577) hydroxymethylglutaryl-CoA synthase.
HMG-CoA-S_euk (TIGR01833) 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:107592 Orthology group for M.musculus Hmgcs1 includes H.sapiens HMGCS1 and R.norvegicus Hmgcs1.

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