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HomoloGene:327. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

AIRE,  H.sapiens
autoimmune regulator
NP_000374.1
545 aa
AIRE,  P.troglodytes
autoimmune regulator
XP_531580.1
545 aa
AIRE,  M.mulatta
autoimmune regulator
XP_001103602.2
526 aa
AIRE,  C.lupus
autoimmune regulator
XP_544921.3
551 aa
AIRE,  B.taurus
autoimmune regulator
XP_002685182.2
575 aa
Aire,  M.musculus
autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
NP_001258478.1
551 aa
Aire,  R.norvegicus
autoimmune regulator
NP_001099849.1
547 aa
aire,  D.rerio
autoimmune regulator
NP_001103484.1
511 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Autoimmune polyglandular disease, type I.



Publications
Articles associated with genes and sequences of this homology group.

Autoimmune regulator, Aire, is a novel regulator of chondrocyte differentiation.
Si Y, et al. Biochem Biophys Res Commun 437, 579-84 (2013).
Age dependent course of EAE in Aire-/- mice.
Aharoni R, et al. J Neuroimmunol 262, 27-34 (2013).
Autoimmune retinopathy in a patient with autoimmune polyendocrine syndrome type I.
Breunig A, et al. Ocul Immunol Inflamm 21, 153-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Sp100 (pfam03172)
  Sp100 domain.
PHD (pfam00628)
  PHD-finger.
RING (cl15348)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
SAND (cl02536)
  SAND domain.
SAND (cl02536)
  SAND domain.
PHD (cl17445)
  PHD-finger.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aire includes H.sapiens AIRE and R.norvegicus Aire.

 

 

 

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