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HomoloGene:327. Gene conserved in Euteleostomi

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	AIRE, H.sapiens autoimmune regulator			NP_000374.1 545 aa
	AIRE, P.troglodytes autoimmune regulator			XP_531580.1 545 aa
	AIRE, M.mulatta autoimmune regulator			XP_001103602.2 526 aa
	AIRE, C.lupus autoimmune regulator			XP_544921.3 551 aa
	AIRE, B.taurus autoimmune regulator			XP_002685182.2 575 aa
	Aire, M.musculus autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)			NP_001258478.1 551 aa
	Aire, R.norvegicus autoimmune regulator			NP_001099849.1 547 aa
	aire, D.rerio autoimmune regulator			NP_001103484.1 511 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:240300 Autoimmune polyglandular disease, type I.

Publications Articles associated with genes and sequences of this homology group.
Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease. Vijmasi T, et al. Mol Vis 19, 1957-65 (2013).
Comparative analysis of induced vs. spontaneous models of autoimmune uveitis targeting the interphotoreceptor retinoid binding protein. Chen J, et al. PLoS One 8, e72161 (2013).
Autoimmune gastro-pancreatitis with anti-protein disulfide isomerase-associated 2 autoantibody in Aire-deficient BALB/cAnN mice. Kurisaki H, et al. PLoS One 8, e73862 (2013).
Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b. Matsuo T, et al. Gene 530, 19-25 (2013).
Autoimmune regulator, Aire, is a novel regulator of chondrocyte differentiation. Si Y, et al. Biochem Biophys Res Commun 437, 579-84 (2013).
Age dependent course of EAE in Aire-/- mice. Aharoni R, et al. J Neuroimmunol 262, 27-34 (2013).
Autoimmune retinopathy in a patient with autoimmune polyendocrine syndrome type I. Breunig A, et al. Ocul Immunol Inflamm 21, 153-7 (2013).
Analysis of the autoimmune regulator gene in patients with autoimmune non-APECED polyendocrinopathies. Palma A, et al. Genomics 102, 163-8 (2013).
Clinical phenotypes of autoimmune polyendocrinopathycandidiasis-ectodermal dystrophy seen in the Northern Ireland paediatric population over the last 30 years. Millar S & Carson D. Ulster Med J 81, 118-22 (2012).
Aire-dependent thymic development of tumor-associated regulatory T cells. Malchow S, et al. Science 339, 1219-24 (2013).
See all (253)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
Sp100 (pfam03172) Sp100 domain.
PHD (pfam00628) PHD-finger.
RING (cl15348) RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
SAND (cl02536) SAND domain.
SAND (cl02536) SAND domain.
PHD (cl17445) PHD-finger.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:1338803 Orthology group for M.musculus Aire includes H.sapiens AIRE and R.norvegicus Aire.

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