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HomoloGene:37396. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

ITGA8,  H.sapiens
integrin, alpha 8
1063 aa
ITGA8,  P.troglodytes
integrin, alpha 8
1063 aa
ITGA8,  M.mulatta
integrin, alpha 8
1063 aa
ITGA8,  C.lupus
integrin, alpha 8
1178 aa
ITGA8,  B.taurus
integrin, alpha 8
1062 aa
Itga8,  M.musculus
integrin alpha 8
1062 aa
Itga8,  R.norvegicus
integrin, alpha 8
1062 aa
ITGA8,  G.gallus
integrin, alpha 8
1044 aa
itga8,  X.tropicalis
integrin, alpha 8
1081 aa
if,  D.melanogaster
1396 aa
AgaP_AGAP000032,  A.gambiae
1540 aa
pat-2,  C.elegans
1226 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Structural gene for the α-subunit of position specific integrin 2 (PS2), a large transmembrane protein (Bogaert, Brown and Wilcox, 1987). The &bgr;-subunit can associate with either of the two α-subunits, PS1 or PS2 (Brower et al., 1984; Wilcox et al., 1984). Both α and &bgr; integrin are expressed in embryonic and larval tissues. In early development, PS2 is found in the mesoderm, localized to muscle attachments (Bogaert, Brown and Wilcox, 1987). Later, PS1 is expressed in the presumptive dorsal epithelium of the third instar imaginal wing discs; also, PS2 is found in the ventral epithelium, both integrins being important for the joining of the dorsal and ventral surfaces of the wing blade (Brower and Jaffe, 1989). (See FlyBase for complete description.)

Articles associated with genes and sequences of this homology group.

Lack of {alpha}8-integrin aggravates podocyte injury in experimental diabetic nephropathy.
Hartner A, et al. Am J Physiol Renal Physiol 299, F1151-7 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Integrin_alpha (pfam00357)
  Integrin alpha cytoplasmic region.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
VCBS (pfam13517)
  Family description.
FG-GAP (cl15299)
  FG-GAP repeat.
Integrin_alpha (pfam00357)
  Integrin alpha cytoplasmic region.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
DUF2756 (cl08110)
  Protein of unknown function (DUF2756).
VCBS (cl15299)
  This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itga8 includes H.sapiens ITGA8 and R.norvegicus Itga8.




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