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HomoloGene:37462. Gene conserved in Eukaryota Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

CHD2,  H.sapiens
chromodomain helicase DNA binding protein 2
1828 aa
CHD2,  P.troglodytes
chromodomain helicase DNA binding protein 2
1318 aa
CHD2,  M.mulatta
chromodomain-helicase-DNA-binding protein 2-like
1806 aa
CHD2,  C.lupus
chromodomain helicase DNA binding protein 2
1793 aa
Chd2,  M.musculus
chromodomain helicase DNA binding protein 2
1827 aa
Chd2,  R.norvegicus
chromodomain helicase DNA binding protein 2
1834 aa
CHD2,  G.gallus
chromodomain helicase DNA binding protein 2
1837 aa
chd2,  X.tropicalis
chromodomain helicase DNA binding protein 2
1809 aa
chd2,  D.rerio
chromodomain helicase DNA binding protein 2
1815 aa
Chd1,  D.melanogaster
Chromodomain-helicase-DNA-binding protein 1
1883 aa
AgaP_AGAP008698,  A.gambiae
2083 aa
chd-1,  C.elegans
1461 aa
CHR5,  A.thaliana
1724 aa
Os07g0660200,  O.sativa
631 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis.
Kulkarni S, et al. Am J Med Genet A 146A, 1117-27 (2008).
Mutation of the SNF2 family member Chd2 affects mouse development and survival.
Marfella CG, et al. J Cell Physiol 209, 162-71 (2006).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF4208 (pfam13907)
  Domain of unknown function (DUF4208).
SNF2_N (pfam00176)
  SNF2 family N-terminal domain.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
SNF2_N (pfam00176)
  SNF2 family N-terminal domain.
MPLKIP (pfam15502)
  M-phase-specific PLK1-interacting protein.
DUF3315 (cl02275)
  Domain of unknown function (DUF3315).
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
CHROMO (cl17459)
  Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence implicates the chromo domain in the binding activity of these proteins to methylated histone tails and maybe RNA. May occur as single instance, in a tandem arrangement or followd by a related "chromo shadow" domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Chd2 includes H.sapiens CHD2 and R.norvegicus Chd2.




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