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HomoloGene:37558. Gene conserved in Eukaryota Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

EPHX2,  H.sapiens
epoxide hydrolase 2, cytoplasmic
555 aa
EPHX2,  P.troglodytes
epoxide hydrolase 2, cytoplasmic
555 aa
EPHX2,  M.mulatta
epoxide hydrolase 2, cytoplasmic
502 aa
EPHX2,  C.lupus
epoxide hydrolase 2, cytoplasmic
556 aa
EPHX2,  B.taurus
epoxide hydrolase 2, cytoplasmic
555 aa
Ephx2,  M.musculus
epoxide hydrolase 2, cytoplasmic
554 aa
Ephx2,  R.norvegicus
epoxide hydrolase 2, cytoplasmic
554 aa
EPHX2,  G.gallus
epoxide hydrolase 2, cytoplasmic
562 aa
ephx2,  X.tropicalis
epoxide hydrolase 2, cytoplasmic
560 aa
ephx2,  D.rerio
epoxide hydrolase 2, cytoplasmic
557 aa
MGG_05175,  M.oryzae
366 aa
AT3G51000,  A.thaliana
323 aa
Os12g0636400,  O.sativa
320 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Hypercholesterolemia, familial, due to LDLR defect, modifier of.

Articles associated with genes and sequences of this homology group.

Epoxyeicosanoids promote organ and tissue regeneration.
Panigrahy D, et al. Proc Natl Acad Sci U S A 110, 13528-33 (2013).
Soluble epoxide hydrolase dimerization is required for hydrolase activity.
Nelson JW, et al. J Biol Chem 288, 7697-7703 (2013).
Epoxyeicosatrienoic acid pathway in human health and diseases.
Bellien J & Joannides R. J Cardiovasc Pharmacol 61, 188-96 (2013).
Altered behavioral phenotypes in soluble epoxide hydrolase knockout mice: effects of traumatic brain injury.
Strauss KI, et al. Prostaglandins Other Lipid Mediat 104-105, 18-24 (2013).
Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats.
Guglielmino K, et al. Am J Physiol Heart Circ Physiol 303, H853-62 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HAD_like (cd01427)
  Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
PRK09456 (PRK09456)
  ?-D-glucose-1-phosphatase; Provisional.
DREG-2 (TIGR02252)
  REG-2-like, HAD superfamily (subfamily IA) hydrolase.
Abhydrolase_1 (pfam00561)
  alpha/beta hydrolase fold.
Esterase_lipase (cl12031)
  Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
Hydrolase_4 (pfam12146)
  Putative lysophospholipase.
Abhydrolase_6 (pfam12697)
  Alpha/beta hydrolase family.
MhpC (COG0596)
  Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].
Abhydrolase_1 (pfam00561)
  alpha/beta hydrolase fold.
Hydrolase_4 (cl19140)
  Putative lysophospholipase.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ephx2 includes H.sapiens EPHX2 and R.norvegicus Ephx2.




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