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HomoloGene:37558. Gene conserved in Eukaryota

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	EPHX2, H.sapiens epoxide hydrolase 2, cytoplasmic			NP_001970.2 555 aa
	EPHX2, P.troglodytes epoxide hydrolase 2, cytoplasmic			XP_001163779.1 555 aa
	EPHX2, M.mulatta epoxide hydrolase 2, cytoplasmic			XP_001109474.2 502 aa
	EPHX2, C.lupus epoxide hydrolase 2, cytoplasmic			XP_005635733.1 556 aa
	EPHX2, B.taurus epoxide hydrolase 2, cytoplasmic			NP_001069002.1 555 aa
	Ephx2, M.musculus epoxide hydrolase 2, cytoplasmic			NP_031966.2 554 aa
	Ephx2, R.norvegicus epoxide hydrolase 2, cytoplasmic			NP_075225.1 554 aa
	EPHX2, G.gallus epoxide hydrolase 2, cytoplasmic			NP_001028817.1 562 aa
	ephx2, X.tropicalis epoxide hydrolase 2, cytoplasmic			NP_001006912.1 560 aa
	ephx2, D.rerio epoxide hydrolase 2, cytoplasmic			NP_001008642.1 557 aa
	MGG_05175, M.oryzae MGG_05175			XP_003712714.1 366 aa
	AT3G51000, A.thaliana AT3G51000			NP_190669.1 323 aa
	Os12g0636400, O.sativa Os12g0636400			NP_001067364.1 320 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:143890 Hypercholesterolemia, familial, due to LDLR defect, modifier of.

Publications Articles associated with genes and sequences of this homology group.
Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus. Jouihan SA, et al. J Cereb Blood Flow Metab 33, 1650-6 (2013).
Epoxyeicosanoids promote organ and tissue regeneration. Panigrahy D, et al. Proc Natl Acad Sci U S A 110, 13528-33 (2013).
Role of endothelial soluble epoxide hydrolase in cerebrovascular function and ischemic injury. Zhang W, et al. PLoS One 8, e61244 (2013).
Soluble epoxide hydrolase dimerization is required for hydrolase activity. Nelson JW, et al. J Biol Chem 288, 7697-7703 (2013).
Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage. Wang Q, et al. Am J Physiol Renal Physiol 304, F168-76 (2013).
Soluble epoxide hydrolase disruption as therapeutic target for wound healing. Sander AL, et al. J Surg Res 182, 362-7 (2013).
Epoxyeicosatrienoic acid pathway in human health and diseases. Bellien J & Joannides R. J Cardiovasc Pharmacol 61, 188-96 (2013).
Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension. Kopkan L, et al. Kidney Blood Press Res 35, 595-607 (2012).
Altered behavioral phenotypes in soluble epoxide hydrolase knockout mice: effects of traumatic brain injury. Strauss KI, et al. Prostaglandins Other Lipid Mediat 104-105, 18-24 (2013).
Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Guglielmino K, et al. Am J Physiol Heart Circ Physiol 303, H853-62 (2012).
See all (155)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
HAD_like (cd01427) Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
PRK09456 (PRK09456) ?-D-glucose-1-phosphatase; Provisional.
DREG-2 (TIGR02252) REG-2-like, HAD superfamily (subfamily IA) hydrolase.
Abhydrolase_1 (pfam00561) alpha/beta hydrolase fold.
Esterase_lipase (cl12031) Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
Hydrolase_4 (pfam12146) Putative lysophospholipase.
Abhydrolase_6 (pfam12697) Alpha/beta hydrolase family.
MhpC (COG0596) Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].
Abhydrolase_1 (pfam00561) alpha/beta hydrolase fold.
Hydrolase_4 (cl19140) Putative lysophospholipase.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:99500 Orthology group for M.musculus Ephx2 includes H.sapiens EPHX2 and R.norvegicus Ephx2.

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