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HomoloGene:38075. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LGMN,  H.sapiens
legumain
NP_001008530.1
433 aa
LGMN,  P.troglodytes
legumain
XP_001148301.1
433 aa
LGMN,  M.mulatta
legumain
XP_001092047.1
426 aa
LGMN,  C.lupus
legumain
XP_537355.2
433 aa
LGMN,  B.taurus
legumain
NP_776526.1
433 aa
Lgmn,  M.musculus
legumain
NP_035305.1
435 aa
Lgmn,  R.norvegicus
legumain
NP_071562.2
435 aa
LGMN,  G.gallus
legumain
XP_421328.1
431 aa
lgmn,  X.tropicalis
legumain
NP_001005720.1
433 aa
lgmn,  D.rerio
legumain
NP_999924.1
438 aa
T28H10.3,  C.elegans
T28H10.3
NP_506137.1
462 aa
DELTA-VPE,  A.thaliana
DELTA-VPE
NP_188656.1
466 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Nuclear legumain activity in colorectal cancer.
Haugen MH, et al. PLoS One 8, e52980 (2013).
Knockdown of legumain inhibits cleavage of annexin A2 in the mouse kidney.
Yamane T, et al. Biochem Biophys Res Commun 430, 482-7 (2013).
Autoactivation of prolegumain is accelerated by glycosaminoglycans.
Berven L, et al. Biochimie 95, 772-81 (2013).
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer.
Wang L, et al. J Cell Biochem 113, 2679-86 (2012).
Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile.
Dall E & Brandstetter H. Acta Crystallogr Sect F Struct Biol Cryst Commun 68, 24-31 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Peptidase_C13 (pfam01650)
  Peptidase C13 family.
Peptidase_C13 (cl02159)
  Peptidase C13 family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lgmn includes H.sapiens LGMN and R.norvegicus Lgmn.

 

 

 

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