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HomoloGene:495. Gene conserved in Euteleostomi

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	TAP1, H.sapiens transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)			NP_000584.2 808 aa
	TAP1, P.troglodytes transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)			XP_001166911.2 808 aa
	TAP1, M.mulatta transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)			XP_001115506.1 808 aa
	TAP1, C.lupus transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)			XP_005627251.1 749 aa
	TAP1, B.taurus transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)			NP_001091527.1 749 aa
	Tap1, M.musculus transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)			NP_038711.2 724 aa
	Tap1, R.norvegicus transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)			NP_114444.2 725 aa
	TAP1, G.gallus transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)			NP_001129440.1 583 aa
	LOC100488534, X.tropicalis antigen peptide transporter 1-like			XP_002942646.1 726 aa
	tap1, D.rerio transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)			XP_002665053.1 731 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:604571 Bare lymphocyte syndrome, type I.

Publications Articles associated with genes and sequences of this homology group.
Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression. Gourapura RJ, et al. PLoS One 8, e72867 (2013).
Association of transporter associated with antigen processing (TAP) gene polymorphisms in donors with acute cellular rejection in living donor liver transplantation. Kamei H, et al. J Gastrointestin Liver Dis 22, 167-71 (2013).
Antigen peptide transporter 1 is involved in the development of fructose-induced hepatic steatosis in mice. Arindkar S, et al. J Gastroenterol Hepatol 28, 1403-9 (2013).
Genetic evidence of TAP1 gene variant as a susceptibility factor in Indian leprosy patients. Shinde V, et al. Hum Immunol 74, 803-7 (2013).
[Relationship between rs1057141 and rs1135216 polymorphisms of TAP1 gene and allergic rhinitis in Xinjiang Han people]. Chen Q, et al. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 26, 917-20, 925 (2012).
Modification of a tumor antigen determinant to improve peptide/MHC stability is associated with increased immunogenicity and cross-priming a larger fraction of CD8+ T cells. Watson AM, et al. J Immunol 189, 5549-60 (2012).
[Relationship between TAP gene promoter methylation and cervical lesions with HPV infection in Uyghur women]. Aikuer G, et al. Zhonghua Bing Li Xue Za Zhi 41, 438-42 (2012).
Purification, crystallization and preliminary X-ray crystallographic analysis of the ATPase domain of human TAP in nucleotide-free and ADP-, vanadate- and azide-complexed forms. Meena SR, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 68, 655-8 (2012).
TAP1-deficiency does not alter atherosclerosis development in Apoe-/- mice. Kolbus D, et al. PLoS One 7, e33932 (2012).
Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cells. Lorente E, et al. J Virol 86, 527-41 (2012).
See all (416)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099) P-loop containing Nucleoside Triphosphate Hydrolases.
ABC_membrane (pfam00664) ABC transporter transmembrane region.
ABC_ATPase (cl17201) ATP-binding cassette transporter nucleotide-binding domain.
ABC_membrane (pfam00664) ABC transporter transmembrane region.
ABC_ATPase (cl17201) ATP-binding cassette transporter nucleotide-binding domain.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:98483 Orthology group for M.musculus Tap1 includes H.sapiens TAP1 and R.norvegicus Tap1.

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