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HomoloGene:55537. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SEC61A1,  H.sapiens
Sec61 alpha 1 subunit (S. cerevisiae)
NP_037468.1
476 aa
SEC61A1,  P.troglodytes
Sec61 alpha 1 subunit (S. cerevisiae)
XP_003310030.1
476 aa
SEC61A1,  M.mulatta
Sec61 alpha 1 subunit (S. cerevisiae)
XP_002798757.1
476 aa
SEC61A1,  C.lupus
Sec61 alpha 1 subunit (S. cerevisiae)
NP_001003315.1
476 aa
SEC61A1,  B.taurus
Sec61 alpha 1 subunit (S. cerevisiae)
NP_001035594.1
476 aa
Sec61a1,  M.musculus
Sec61 alpha 1 subunit (S. cerevisiae)
NP_058602.1
476 aa
Sec61a1,  R.norvegicus
Sec61 alpha 1 subunit (S. cerevisiae)
NP_954865.1
476 aa
SEC61A1,  G.gallus
Sec61 alpha 1 subunit (S. cerevisiae)
XP_414364.3
476 aa
sec61a1,  X.tropicalis
Sec61 alpha 1 subunit
NP_001004801.1
476 aa
sec61a1,  D.rerio
Sec61 alpha 1 subunit (S. cerevisiae)
NP_705945.1
476 aa
sec61al2,  D.rerio
Sec61 alpha like 2
NP_963871.1
476 aa
SEC61,  S.cerevisiae
SEC61
NP_013482.1
480 aa
KLLA0E01145g,  K.lactis
KLLA0E01145g
XP_454000.1
480 aa
AGOS_AFR596W,  E.gossypii
AGOS_AFR596W
NP_986143.1
480 aa
sec61,  S.pombe
sec61
NP_595226.1
479 aa
MGG_04856,  M.oryzae
MGG_04856
XP_003712335.1
476 aa
NCU08897,  N.crassa
NCU08897
XP_958835.1
476 aa
AT1G29310,  A.thaliana
AT1G29310
NP_174225.2
475 aa
AT2G34250,  A.thaliana
AT2G34250
NP_180972.1
475 aa
Os03g0213100,  O.sativa
Os03g0213100
NP_001049359.1
475 aa
Os09g0347700,  O.sativa
Os09g0347700
NP_001062945.1
475 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Functional asymmetry within the Sec61p translocon.
Demirci E, et al. Proc Natl Acad Sci U S A 110, 18856-61 (2013).
Contribution of Sec61α to the life cycle of Ebola virus.
Iwasa A, et al. J Infect Dis 204 Suppl 3, S919-26 (2011).
Sec61 complexes form ubiquitous ER Ca2+ leak channels.
Lang S, et al. Channels (Austin) 5, 228-35 (2011).
The mammalian and yeast translocon complexes comprise a characteristic Sec61 channel.
Erdmann F, et al. Biochem Biophys Res Commun 396, 714-20 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Plug_translocon (pfam10559)
  Plug domain of Sec61p.
SecY (pfam00344)
  SecY translocase.
SecY (pfam00344)
  SecY translocase.
Plug_translocon (pfam10559)
  Plug domain of Sec61p.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sec61a1 includes H.sapiens SEC61a1 and R.norvegicus Sec61a1.

 

 

 

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