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HomoloGene:74455. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

CLIP1,  H.sapiens
CAP-GLY domain containing linker protein 1
1392 aa
CLIP1,  P.troglodytes
CAP-GLY domain containing linker protein 1
1433 aa
CLIP1,  M.mulatta
CAP-GLY domain containing linker protein 1
1438 aa
CLIP1,  C.lupus
CAP-GLY domain containing linker protein 1
1438 aa
CLIP1,  B.taurus
CAP-GLY domain containing linker protein 1
1427 aa
Clip1,  M.musculus
CAP-GLY domain containing linker protein 1
1391 aa
CLIP1,  G.gallus
CAP-GLY domain containing linker protein 1
1433 aa
clip1,  X.tropicalis
CAP-GLY domain containing linker protein 1
1150 aa
clip1a,  D.rerio
CAP-GLY domain containing linker protein 1a
1377 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells.
Suzuki K & Takahashi K. Biochem Biophys Res Commun 368, 199-204 (2008).
CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1.
Hayashi I, et al. Nat Struct Mol Biol 14, 980-1 (2007).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CAP_GLY (pfam01302)
  CAP-Gly domain.
SMC_prok_B (TIGR02168)
  chromosome segregation protein SMC, common bacterial type.
eIF-4B (pfam06273)
  Plant specific eukaryotic initiation factor 4B.
CAP_GLY (cl08315)
  Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.
DUF342 (cl19219)
  Protein of unknown function (DUF342).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Clip1 includes H.sapiens CLIP1 and R.norvegicus Clip1.




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