HomoloGene - NCBI

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HomoloGene:7751. Gene conserved in Amniota

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	HLA-DRA, H.sapiens major histocompatibility complex, class II, DR alpha			NP_061984.2 254 aa
	PATR-DRA, P.troglodytes major histocompatibility complex, class II, DR alpha			NP_001127811.1 254 aa
	MAMU-DRA, M.mulatta major histocompatibility complex, class II, DR alpha			NP_001127770.1 254 aa
	DLA-DRA, C.lupus MHC class II DR alpha chain			NP_001011723.1 254 aa
	BOLA-DRA, B.taurus major histocompatibility complex, class II, DR alpha			NP_001012695.1 253 aa
	H2-Ea-ps, M.musculus histocompatibility 2, class II antigen E alpha, pseudogene			XP_003688998.1 276 aa
	RT1-Da, R.norvegicus RT1 class II, locus Da			NP_001008847.1 255 aa
	BLA, G.gallus Major histocompatibility complex class II alpha chain BLA, (similar to HLA class II, D alpha chain)			NP_001231990.1 255 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
The HLA-DRA variation rs3129882 is not associated with Parkinson's disease in Sweden. Ran C, et al. Parkinsonism Relat Disord 19, 701-2 (2013).
Common variants in HLA-DRA gene are associated with alcohol dependence in two Caucasian samples. Pan Y, et al. J Mol Neurosci 49, 574-81 (2013).
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia. Zhao H, et al. Am J Hum Genet 90, 900-6 (2012).
HLA-DRA polymorphisms associated with risk of nasal polyposis in asthmatic patients. Kim JH, et al. Am J Rhinol Allergy 26, 12-7 (2012).
Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease. Chiang HL, et al. Parkinsonism Relat Disord 18, 391-3 (2012).
Human leukocyte antigen variation and Parkinson's disease. Puschmann A, et al. Parkinsonism Relat Disord 17, 376-8 (2011).
Inflammation and epithelial cell injury in AIDS enteropathy: involvement of endoplasmic reticulum stress. Maingat F, et al. FASEB J 25, 2211-20 (2011).
Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions. Taflin C, et al. Proc Natl Acad Sci U S A 108, 2891-6 (2011).
The impacts of continuous veno-venous hemofiltration on plasma cytokines and monocyte human leukocyte antigen-DR expression in septic patients. Peng Z, et al. Cytokine 50, 186-91 (2010).
Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, et al. Virus Res 145, 260-9 (2009).
See all (297)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
MHC_II_alpha (cl03058) Class II MHC glycoproteins are expressed on the surface of antigen-presenting cells (APC), including macrophages, dendritic cells and B cells. MHC II proteins present peptide antigens that originate extracellularly from foreign bodies such as bacteria. Proteins from the pathogen are degraded into peptide fragments within the APC, which sequesters these fragments into the endosome so they can bind to MHC class II proteins, before being transported to the cell surface. MHC class II receptors display antigens for recognition by helper T cells (stimulate development of B cell clones) and inflammatory T cells (cause the release of lymphokines that attract other cells to site of infection).
Ig (cl11960) Immunoglobulin domain.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:95900 Orthology group for M.musculus H2-Ea-ps includes H.sapiens HLA-DRA.

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