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HomoloGene:828. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TNFRSF1A,  H.sapiens
tumor necrosis factor receptor superfamily, member 1A
NP_001056.1
455 aa
TNFRSF1A,  P.troglodytes
tumor necrosis factor receptor superfamily, member 1A
XP_522334.3
427 aa
TNFRSF1A,  M.mulatta
tumor necrosis factor receptor superfamily, member 1A
XP_001118232.2
347 aa
TNFRSF1A,  C.lupus
tumor necrosis factor receptor superfamily, member 1A
XP_854474.1
452 aa
TNFRSF1A,  B.taurus
tumor necrosis factor receptor superfamily, member 1A
NP_777099.1
471 aa
Tnfrsf1a,  M.musculus
tumor necrosis factor receptor superfamily, member 1a
NP_035739.2
454 aa
Tnfrsf1a,  R.norvegicus
tumor necrosis factor receptor superfamily, member 1a
NP_037223.1
461 aa
TNFRSF1A,  G.gallus
tumor necrosis factor receptor superfamily, member 1A
NP_001025950.1
427 aa
tnfrsf1a,  X.tropicalis
tumor necrosis factor receptor superfamily, member 1A
NP_001119976.1
410 aa
tnfrsf1a,  D.rerio
tumor necrosis factor receptor superfamily, member 1a
NP_998355.1
389 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Periodic fever, familial.



Publications
Articles associated with genes and sequences of this homology group.

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium.
Van Hauwermeiren F, et al. J Clin Invest 123, 2590-603 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TNFR (cd00185)
  Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tnfrsf1a includes H.sapiens TNFRSF1A and R.norvegicus Tnfrsf1a.

 

 

 

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