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HomoloGene:20058. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ACVRL1,  H.sapiens
activin A receptor type II-like 1
NP_001070869.1
503 aa
ACVRL1,  P.troglodytes
activin A receptor type II-like 1
XP_001145609.1
503 aa
ACVRL1,  M.mulatta
activin A receptor type II-like 1
XP_001091113.1
503 aa
ACVRL1,  C.lupus
activin A receptor type II-like 1
XP_005636859.1
523 aa
ACVRL1,  B.taurus
activin A receptor type II-like 1
NP_001076948.1
503 aa
Acvrl1,  M.musculus
activin A receptor, type II-like 1
NP_001264184.1
517 aa
Acvrl1,  R.norvegicus
activin A receptor type II-like 1
NP_071886.1
504 aa
ACVRL1,  G.gallus
activin A receptor type II-like 1
XP_003643441.2
525 aa
LOC100493282,  X.tropicalis
activin receptor type-1-like
XP_002935162.2
505 aa
acvrl1,  D.rerio
activin A receptor type II-like 1
NP_705929.1
499 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hereditary hemorrhagic telangiectasia-2.



Publications
Articles associated with genes and sequences of this homology group.

The expression of activin receptor-like kinase 1 among patients with head and neck cancer.
Chien CY, et al. Otolaryngol Head Neck Surg 148, 965-73 (2013).
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.
Larrivée B, et al. Dev Cell 22, 489-500 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pkinase (pfam00069)
  Protein kinase domain.
Activin_recp (pfam01064)
  Activin types I and II receptor domain.
TGF_beta_GS (pfam08515)
  Transforming growth factor beta type I GS-motif.
Pkinase (pfam00069)
  Protein kinase domain.
Activin_recp (pfam01064)
  Activin types I and II receptor domain.
TGF_beta_GS (cl02621)
  This motif is found in the transforming growth factor beta (TGF-beta) type I which regulates cell growth and differentiation. The name of the GS motif comes from its highly conserved GSGSGLP signature in the cytoplasmic juxtamembrane region immediately preceding the protein's kinase domain. Point mutations in the GS motif modify the signaling ability of the type I receptor.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Acvrl1 includes H.sapiens ACVRL1 and R.norvegicus Acvrl1.

 

 

 

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