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HomoloGene:443. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

VLDLR,  H.sapiens
very low density lipoprotein receptor
NP_003374.3
873 aa
VLDLR,  P.troglodytes
very low density lipoprotein receptor
XP_520460.3
873 aa
VLDLR,  M.mulatta
very low density lipoprotein receptor
NP_001028079.1
873 aa
VLDLR,  C.lupus
very low density lipoprotein receptor
XP_533538.2
873 aa
VLDLR,  B.taurus
very low density lipoprotein receptor
NP_776914.1
845 aa
Vldlr,  M.musculus
very low density lipoprotein receptor
NP_038731.2
873 aa
Vldlr,  R.norvegicus
very low density lipoprotein receptor
NP_037287.2
873 aa
VLDLR,  G.gallus
very low density lipoprotein receptor
NP_990560.1
863 aa
vldlr,  X.tropicalis
very low density lipoprotein receptor
XP_002934223.1
868 aa
vldlr,  D.rerio
very low density lipoprotein receptor
NP_957217.2
866 aa
LpR2,  D.melanogaster
Lipophorin receptor 2
NP_001097928.1
1064 aa
LpR1,  D.melanogaster
Lipophorin receptor 1
NP_001262974.1
868 aa
AgaP_AGAP002186,  A.gambiae
AgaP_AGAP002186
XP_003436050.1
894 aa
T13C2.6,  C.elegans
T13C2.6
NP_872023.2
911 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cerebellar hypoplasia, VLDLR-associated.



Publications
Articles associated with genes and sequences of this homology group.

The role of Vldlr in intraretinal angiogenesis in mice.
Xia CH, et al. Invest Ophthalmol Vis Sci 52, 6572-9 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LY (smart00135)
  Low-density lipoprotein-receptor YWTD domain.
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
LDLa (cl00104)
  Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
Mucin (pfam01456)
  Mucin-like glycoprotein.
LDLa (cl00104)
  Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vldlr includes H.sapiens VLDLR and R.norvegicus Vldlr.

 

 

 

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