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HomoloGene:856. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ACO2,  H.sapiens
aconitase 2, mitochondrial
NP_001089.1
780 aa
ACO2,  M.mulatta
aconitase 2, mitochondrial
XP_001105023.1
780 aa
ACO2,  C.lupus
aconitase 2, mitochondrial
XP_849166.1
781 aa
ACO2,  B.taurus
aconitase 2, mitochondrial
NP_776402.1
780 aa
Aco2,  M.musculus
aconitase 2, mitochondrial
NP_542364.1
780 aa
Aco2,  R.norvegicus
aconitase 2, mitochondrial
NP_077374.2
780 aa
ACO2,  G.gallus
aconitase 2, mitochondrial
NP_989519.1
785 aa
aco2,  X.tropicalis
aconitase 2, mitochondrial
NP_001011445.1
781 aa
aco2,  D.rerio
aconitase 2, mitochondrial
NP_944590.1
782 aa
Acon,  D.melanogaster
Aconitase
NP_001163030.1
787 aa
AgaP_AGAP007852,  A.gambiae
AgaP_AGAP007852
XP_317642.4
786 aa
aco-2,  C.elegans
aco-2
NP_741235.1
777 aa
ACO1,  S.cerevisiae
ACO1
NP_013407.1
778 aa
KLLA0C17314g,  K.lactis
KLLA0C17314g
XP_452974.1
788 aa
AGOS_ADL032W,  E.gossypii
AGOS_ADL032W
NP_984065.1
776 aa
SPAC24C9.06c,  S.pombe
SPAC24C9.06c
NP_594031.2
789 aa
MGG_03521,  M.oryzae
MGG_03521
XP_003716398.1
784 aa
NCU02366,  N.crassa
NCU02366
XP_959787.1
784 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency.
Cheng Z, et al. Biochem Biophys Res Commun 433, 145-50 (2013).
Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA.
Chen XJ, et al. Proc Natl Acad Sci U S A 104, 13738-43 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Aconitase_swivel (cl00215)
  Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme ...
Aconitase (cl00285)
  Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aco2 includes H.sapiens ACO2 and R.norvegicus Aco2.


 

 

 

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