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HomoloGene:20523. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

KRT4,  H.sapiens
keratin 4
520 aa
KRT4,  P.troglodytes
keratin 4
534 aa
KRT4,  M.mulatta
keratin 4
520 aa
KRT4,  C.lupus
keratin 4
603 aa
KRT4,  B.taurus
keratin 4
549 aa
Krt4,  M.musculus
keratin 4
525 aa
Krt4,  R.norvegicus
keratin 4
536 aa
KRT4,  G.gallus
keratin 4
550 aa
LOC100489468,  X.tropicalis
keratin, type II cytoskeletal 5-like
570 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

White sponge nevus.

Articles associated with genes and sequences of this homology group.

Mutation of keratin 4 gene causing white sponge nevus in a Japanese family.
Kimura M, et al. Int J Oral Maxillofac Surg 42, 615-8 (2013).
A novel mutation in the keratin 4 gene causing white sponge naevus.
Chao SC, et al. Br J Dermatol 148, 1125-8 (2003).
Mouse keratin 4 is necessary for internal epithelial integrity.
Ness SL, et al. J Biol Chem 273, 23904-11 (1998).
Allele frequencies and segregation of human polymorphic keratins K4 and K5.
Mischke D, et al. Am J Hum Genet 46, 548-52 (1990).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TraC (cl06725)
  TraC-like protein.
Orbi_VP5 (pfam00901)
  Orbivirus outer capsid protein VP5.
Filament (pfam00038)
  Intermediate filament protein.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.
Biotin_lipoyl_2 (cl19169)
  Biotin-lipoyl like.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Krt4 includes H.sapiens KRT4 and R.norvegicus Krt4.




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