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HomoloGene:32586. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MCPH1,  H.sapiens
microcephalin 1
NP_078872.2
835 aa
MCPH1,  P.troglodytes
microcephalin 1
NP_001009010.1
835 aa
MCPH1,  C.lupus
microcephalin 1
NP_001003366.1
850 aa
MCPH1,  B.taurus
microcephalin 1
NP_001096785.1
838 aa
Mcph1,  M.musculus
microcephaly, primary autosomal recessive 1
NP_775281.2
822 aa
Mcph1,  R.norvegicus
microcephalin 1
XP_006253445.1
808 aa
MCPH1,  G.gallus
microcephalin 1
NP_001098789.1
513 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Microcephaly, autosomal recessive 1.
Premature chromosome condensation with microcephaly and mental retardation.



Publications
Articles associated with genes and sequences of this homology group.

Mcph1-deficient mice reveal a role for MCPH1 in otitis media.
Chen J, et al. PLoS One 8, e58156 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BRCT (pfam00533)
  BRCA1 C Terminus (BRCT) domain.
Microcephalin (pfam12258)
  Microcephalin protein.
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
Microcephalin (pfam12258)
  Microcephalin protein.
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mcph1 includes H.sapiens MCPH1 and R.norvegicus Mcph1.


 

 

 

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