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HomoloGene:134. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GHR,  H.sapiens
growth hormone receptor
NP_001229328.1
645 aa
GHR,  P.troglodytes
growth hormone receptor
XP_003950612.1
645 aa
GHR,  M.mulatta
growth hormone receptor
NP_001036132.1
638 aa
GHR,  C.lupus
growth hormone receptor
NP_001003123.1
638 aa
GHR,  B.taurus
growth hormone receptor
NP_788781.1
634 aa
Ghr,  M.musculus
growth hormone receptor
NP_001273299.1
650 aa
Ghr,  R.norvegicus
growth hormone receptor
NP_058790.1
638 aa
GHR,  G.gallus
growth hormone receptor
NP_001001293.1
608 aa
ghr,  X.tropicalis
growth hormone receptor
XP_002933093.2
621 aa
ghra,  D.rerio
growth hormone receptor a
NP_001077047.1
570 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Laron dwarfism.
Increased responsiveness to growth hormone.
Short stature, autosomal dominant, with normal serum growth hormone binding protein.
Short stature, idiopathic.



Publications
Articles associated with genes and sequences of this homology group.

Growth hormone receptor (GHR) gene polymorphism and Prader-Willi syndrome.
Butler MG, et al. Am J Med Genet A 161A, 1647-53 (2013).
Hepatic growth hormone resistance after acute injury.
Corrick RM, et al. Endocrinology 154, 1577-88 (2013).
Growth hormone receptor expression in brain tumors.
Sakoguchi T, et al. Hiroshima J Med Sci 61, 1-6 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IL6Ra-bind (cl12153)
  Interleukin-6 receptor alpha chain, binding.
EpoR_lig-bind (pfam09067)
  Erythropoietin receptor, ligand binding.
GHBP (pfam12772)
  Growth hormone receptor binding.
EpoR_lig-bind (pfam09067)
  Erythropoietin receptor, ligand binding.
GHBP (pfam12772)
  Growth hormone receptor binding.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ghr includes H.sapiens GHR and R.norvegicus Ghr.


 

 

 

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