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HomoloGene:2890. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PROZ,  H.sapiens
protein Z, vitamin K-dependent plasma glycoprotein
NP_003882.1
400 aa
PROZ,  P.troglodytes
protein Z, vitamin K-dependent plasma glycoprotein
XP_522739.3
400 aa
PROZ,  M.mulatta
protein Z, vitamin K-dependent plasma glycoprotein
XP_001087442.1
400 aa
PROZ,  B.taurus
protein Z, vitamin K-dependent plasma glycoprotein
XP_002692060.3
442 aa
Proz,  M.musculus
protein Z, vitamin K-dependent plasma glycoprotein
NP_080110.1
399 aa
Proz,  R.norvegicus
protein Z, vitamin K-dependent plasma glycoprotein
XP_006253535.1
440 aa
PROZ,  G.gallus
protein Z, vitamin K-dependent plasma glycoprotein
XP_416945.3
407 aa
proz,  X.tropicalis
protein Z, vitamin K-dependent plasma glycoprotein
NP_001116189.1
416 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

[Protein Z deficiency in unexplained affinity to thromboses, bleedings or abortions].
Kiesewetter H, et al. Hamostaseologie 32 Suppl 1, S95-7 (2012).
Protein Z concentrations in patients with acute leukemia.
Galar M, et al. Clin Appl Thromb Hemost 18, 542-5 (2012).
Protein Z levels in pregnant Omani women: correlation with pregnancy outcome.
Gowri V, et al. J Thromb Thrombolysis 32, 453-8 (2011).
Protein Z is present in human breast cancer tissue.
Sierko E, et al. Int J Hematol 93, 681-683 (2011).
Low levels of protein Z are associated with HELLP syndrome and its severity.
Kaygusuz I, et al. Clin Appl Thromb Hemost 17, 214-9 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tryp_SPc (smart00020)
  Trypsin-like serine protease.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Tryp_SPc (cl00149)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Gla (cl02449)
  Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Proz includes H.sapiens PROZ and R.norvegicus Proz.

 

 

 

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