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Batten-Turner congenital myopathy

MedGen UID:
10158
Concept ID:
C0027127
Disease or Syndrome
Synonym: Myotonia congenita
 
Related gene: CLCN1
 
Monarch Initiative: MONDO:0100468
OMIM®: 255300

Disease characteristics

Excerpted from the GeneReview: Myotonia Congenita
Myotonia congenita is characterized by muscle stiffness present from childhood; all striated muscle groups including the extrinsic eye muscles, facial muscles, and tongue may be involved. Stiffness is relieved by repeated contractions of the muscle (the "warm-up" phenomenon). Muscles are usually hypertrophic. Whereas autosomal recessive (AR) myotonia congenita is often associated with more severe manifestations (such as progressive minor distal weakness and attacks of transient weakness brought on by movement after rest), autosomal dominant (AD) myotonia congenita is not. The age of onset varies: in AD myotonia congenita onset is usually in infancy or early childhood; in AR myotonia congenita the average age of onset is slightly older. In both AR and AD myotonia congenita onset may be as late as the third or fourth decade of life. [from GeneReviews]
Authors:
Morten Dunø  |  John Vissing   view full author information

Additional description

From MedlinePlus Genetics
Myotonia congenita is a disorder that affects muscles used for movement (skeletal muscles). Beginning in childhood, people with this condition experience bouts of sustained muscle tensing (myotonia) that prevent muscles from relaxing normally. Although myotonia can affect any skeletal muscles, including muscles of the face and tongue, it occurs most often in the legs. Myotonia causes muscle stiffness that can interfere with movement. In some people the stiffness is very mild, while in other cases it may be severe enough to interfere with walking, running, and other activities of daily life. These muscle problems are particularly noticeable during movement following a period of rest. Many affected individuals find that repeated movements can temporarily alleviate their muscle stiffness, a phenomenon known as the warm-up effect.

The two major types of myotonia congenita are known as Thomsen disease and Becker disease. These conditions are distinguished by the severity of their symptoms and their patterns of inheritance. Becker disease usually appears later in childhood than Thomsen disease and causes more severe muscle stiffness, particularly in males. People with Becker disease often experience temporary attacks of muscle weakness, particularly in the arms and hands, brought on by movement after periods of rest. They may also develop mild, permanent muscle weakness over time. This muscle weakness is not seen in people with Thomsen disease.  https://medlineplus.gov/genetics/condition/myotonia-congenita

Clinical features

From HPO
Abnormality of the nervous system
MedGen UID:
105425
Concept ID:
C0497552
Congenital Abnormality
An abnormality of the nervous system.
Myopathy
MedGen UID:
10135
Concept ID:
C0026848
Disease or Syndrome
A disorder of muscle unrelated to impairment of innervation or neuromuscular junction.

Term Hierarchy

Professional guidelines

PubMed

Stunnenberg BC, LoRusso S, Arnold WD, Barohn RJ, Cannon SC, Fontaine B, Griggs RC, Hanna MG, Matthews E, Meola G, Sansone VA, Trivedi JR, van Engelen BGM, Vicart S, Statland JM
Muscle Nerve 2020 Oct;62(4):430-444. Epub 2020 May 27 doi: 10.1002/mus.26887. PMID: 32270509Free PMC Article
Zhang K, Yang X, Lin G, Han Y, Li J
Clin Chim Acta 2019 Apr;491:66-73. Epub 2019 Jan 17 doi: 10.1016/j.cca.2019.01.014. PMID: 30660698
Massalska D, Zimowski JG, Bijok J, Kucińska-Chahwan A, Łusakowska A, Jakiel G, Roszkowski T
Clin Genet 2016 Sep;90(3):199-210. Epub 2016 Jun 2 doi: 10.1111/cge.12801. PMID: 27197572

Recent clinical studies

Etiology

Suetterlin K, Matthews E, Sud R, McCall S, Fialho D, Burge J, Jayaseelan D, Haworth A, Sweeney MG, Kullmann DM, Schorge S, Hanna MG, Männikkö R
Brain 2022 Apr 18;145(2):607-620. doi: 10.1093/brain/awab344. PMID: 34529042Free PMC Article
Vivekanandam V, Munot P, Hanna MG, Matthews E
Neurol Clin 2020 Aug;38(3):481-491. doi: 10.1016/j.ncl.2020.04.003. PMID: 32703462
Massalska D, Zimowski JG, Bijok J, Kucińska-Chahwan A, Łusakowska A, Jakiel G, Roszkowski T
Clin Genet 2016 Sep;90(3):199-210. Epub 2016 Jun 2 doi: 10.1111/cge.12801. PMID: 27197572
North KN, Wang CH, Clarke N, Jungbluth H, Vainzof M, Dowling JJ, Amburgey K, Quijano-Roy S, Beggs AH, Sewry C, Laing NG, Bönnemann CG; International Standard of Care Committee for Congenital Myopathies
Neuromuscul Disord 2014 Feb;24(2):97-116. Epub 2013 Nov 18 doi: 10.1016/j.nmd.2013.11.003. PMID: 24456932Free PMC Article
Finsterer J
Acta Neurol Scand 2008 Mar;117(3):145-58. Epub 2007 Nov 20 doi: 10.1111/j.1600-0404.2007.00963.x. PMID: 18031562

Diagnosis

Vivekanandam V, Jayaseelan D, Hanna MG
Handb Clin Neurol 2023;195:521-532. doi: 10.1016/B978-0-323-98818-6.00006-6. PMID: 37562884
Suetterlin K, Matthews E, Sud R, McCall S, Fialho D, Burge J, Jayaseelan D, Haworth A, Sweeney MG, Kullmann DM, Schorge S, Hanna MG, Männikkö R
Brain 2022 Apr 18;145(2):607-620. doi: 10.1093/brain/awab344. PMID: 34529042Free PMC Article
Vivekanandam V, Munot P, Hanna MG, Matthews E
Neurol Clin 2020 Aug;38(3):481-491. doi: 10.1016/j.ncl.2020.04.003. PMID: 32703462
Stunnenberg BC, LoRusso S, Arnold WD, Barohn RJ, Cannon SC, Fontaine B, Griggs RC, Hanna MG, Matthews E, Meola G, Sansone VA, Trivedi JR, van Engelen BGM, Vicart S, Statland JM
Muscle Nerve 2020 Oct;62(4):430-444. Epub 2020 May 27 doi: 10.1002/mus.26887. PMID: 32270509Free PMC Article
Glasberg MR
Neurosurgery 1979 Dec;5(6):747-58. doi: 10.1227/00006123-197912000-00017. PMID: 392333

Therapy

Adaikina A, Derraik JGB, Power LC, Grady GO, Munns CF, Hofman PL, Gusso S
Neuromuscul Disord 2022 Oct;32(10):820-828. Epub 2022 Jul 28 doi: 10.1016/j.nmd.2022.07.398. PMID: 35973877
Stunnenberg BC, LoRusso S, Arnold WD, Barohn RJ, Cannon SC, Fontaine B, Griggs RC, Hanna MG, Matthews E, Meola G, Sansone VA, Trivedi JR, van Engelen BGM, Vicart S, Statland JM
Muscle Nerve 2020 Oct;62(4):430-444. Epub 2020 May 27 doi: 10.1002/mus.26887. PMID: 32270509Free PMC Article
Adaikina A, Hofman PL, O'Grady GL, Gusso S
Pediatr Neurol 2020 Mar;104:13-18. Epub 2019 Nov 29 doi: 10.1016/j.pediatrneurol.2019.10.008. PMID: 31926608
Jungbluth H, Ochala J, Treves S, Gautel M
Semin Cell Dev Biol 2017 Apr;64:191-200. Epub 2016 Aug 8 doi: 10.1016/j.semcdb.2016.08.004. PMID: 27515125
Finkel MJ
Clin Ther 1984;6(5):577-91. PMID: 6383610

Prognosis

Marinella G, Orsini A, Scacciati M, Costa E, Santangelo A, Astrea G, Frosini S, Pasquariello R, Rubegni A, Sgherri G, Corsi M, Bonuccelli A, Battini R
Genes (Basel) 2023 Jun 28;14(7) doi: 10.3390/genes14071363. PMID: 37510268Free PMC Article
Croci C, Traverso M, Baratto S, Iacomino M, Pedemonte M, Caroli F, Scala M, Bruno C, Fiorillo C
Acta Myol 2022;41(3):111-116. Epub 2022 Sep 30 doi: 10.36185/2532-1900-076. PMID: 36349186Free PMC Article
Schirwani S, Sarkozy A, Phadke R, Childs AM, Mein R, Ismail A, Smith A, Muntoni F, Hobson E, Pysden K
Neuromuscul Disord 2021 Apr;31(4):359-366. Epub 2020 Oct 3 doi: 10.1016/j.nmd.2020.09.033. PMID: 33558124
Ravenscroft G, Bryson-Richardson RJ, Nowak KJ, Laing NG
F1000Res 2018;7 Epub 2018 Dec 11 doi: 10.12688/f1000research.16422.1. PMID: 30631434Free PMC Article
Witting N, Werlauff U, Duno M, Vissing J
Muscle Nerve 2016 Mar;53(3):388-93. Epub 2015 Aug 13 doi: 10.1002/mus.24765. PMID: 26172852

Clinical prediction guides

Croci C, Traverso M, Baratto S, Iacomino M, Pedemonte M, Caroli F, Scala M, Bruno C, Fiorillo C
Acta Myol 2022;41(3):111-116. Epub 2022 Sep 30 doi: 10.36185/2532-1900-076. PMID: 36349186Free PMC Article
Gurgel-Giannetti J, Souza LS, Yamamoto GL, Belisario M, Lazar M, Campos W, Pavanello RCM, Zatz M, Reed U, Zanoteli E, Oliveira AB, Lehtokari VL, Casella EB, Machado-Costa MC, Wallgren-Pettersson C, Laing NG, Nigro V, Vainzof M
Int J Mol Sci 2022 Oct 9;23(19) doi: 10.3390/ijms231911995. PMID: 36233295Free PMC Article
Li Y, Li M, Wang Z, Yang F, Wang H, Bai X, Sun B, Chen S, Huang X
Channels (Austin) 2022 Dec;16(1):35-46. doi: 10.1080/19336950.2022.2041292. PMID: 35170402Free PMC Article
Vivekanandam V, Männikkö R, Matthews E, Hanna MG
Expert Rev Mol Diagn 2020 Jul;20(7):725-736. Epub 2020 Jul 12 doi: 10.1080/14737159.2020.1782195. PMID: 32657178
Ravenscroft G, Bryson-Richardson RJ, Nowak KJ, Laing NG
F1000Res 2018;7 Epub 2018 Dec 11 doi: 10.12688/f1000research.16422.1. PMID: 30631434Free PMC Article

Recent systematic reviews

Marinella G, Orsini A, Scacciati M, Costa E, Santangelo A, Astrea G, Frosini S, Pasquariello R, Rubegni A, Sgherri G, Corsi M, Bonuccelli A, Battini R
Genes (Basel) 2023 Jun 28;14(7) doi: 10.3390/genes14071363. PMID: 37510268Free PMC Article
Trip J, Drost G, van Engelen BG, Faber CG
Cochrane Database Syst Rev 2006 Jan 25;2006(1):CD004762. doi: 10.1002/14651858.CD004762.pub2. PMID: 16437496Free PMC Article

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