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Benign neoplasm of mediastinum

MedGen UID:
102298
Concept ID:
C0153956
Neoplastic Process
Synonyms: Benign Mediastinal Neoplasm; benign mediastinal neoplasm; Benign Mediastinal Neoplasms NOS; Benign Mediastinal Tumor; benign mediastinal tumor; benign mediastinal tumour; Benign Neoplasm of Mediastinum; benign neoplasm of mediastinum; Benign Neoplasm of the Mediastinum; benign neoplasm of the mediastinum; Benign tumor of mediastinum; Benign Tumor of Mediastinum; benign tumor of mediastinum; Benign Tumor of the Mediastinum; benign tumor of the mediastinum; benign tumour of mediastinum; benign tumour of the mediastinum; mediastinum benign neoplasm
SNOMED CT: Benign tumor of mediastinum (92214000); Benign neoplasm of mediastinum (92214000)
 
Monarch Initiative: MONDO:0021521

Definition

A neoplasm that arises from the mediastinum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include lipoma, leiomyoma, and schwannoma. [from NCI]

Professional guidelines

PubMed

Kobayashi K, Hanai N, Yoshimoto S, Saito Y, Homma A
Jpn J Clin Oncol 2023 Aug 30;53(9):743-756. doi: 10.1093/jjco/hyad048. PMID: 37309253Free PMC Article
Ahmed Z, Afridi SS, Shahid Z, Zamani Z, Rehman S, Aiman W, Khan M, Mir MA, Awan FT, Anwer F, Iftikhar R
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):e865-e875. Epub 2021 Jun 24 doi: 10.1016/j.clml.2021.06.012. PMID: 34330673
Silvestri GA, Gonzalez AV, Jantz MA, Margolis ML, Gould MK, Tanoue LT, Harris LJ, Detterbeck FC
Chest 2013 May;143(5 Suppl):e211S-e250S. doi: 10.1378/chest.12-2355. PMID: 23649440

Recent clinical studies

Etiology

Gerber TS, Porubsky S
Histopathology 2024 Jan;84(1):183-195. Epub 2023 Nov 21 doi: 10.1111/his.15088. PMID: 37988262
Botana-Rial M, Lojo-Rodríguez I, Leiro-Fernández V, Ramos-Hernández C, González-Montaos A, Pazos-Area L, Núñez-Delgado M, Fernández-Villar A
Respir Med 2023 Nov;218:107389. Epub 2023 Aug 12 doi: 10.1016/j.rmed.2023.107389. PMID: 37579981
Sreedher G, Tadros SS, Janitz E
Pediatr Radiol 2022 Sep;52(10):1935-1947. Epub 2022 Jun 8 doi: 10.1007/s00247-022-05409-4. PMID: 35674800
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
Carter BW, Benveniste MF, Madan R, Godoy MC, de Groot PM, Truong MT, Rosado-de-Christenson ML, Marom EM
Radiographics 2017 Mar-Apr;37(2):413-436. Epub 2017 Jan 27 doi: 10.1148/rg.2017160095. PMID: 28129068

Diagnosis

Dunne EG, Fick CN, Jones DR
J Clin Oncol 2023 Aug 1;41(22):3785-3790. Epub 2023 Jun 2 doi: 10.1200/JCO.23.00867. PMID: 37267507Free PMC Article
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P
J Thorac Oncol 2022 Feb;17(2):200-213. Epub 2021 Oct 22 doi: 10.1016/j.jtho.2021.10.010. PMID: 34695605
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
Carter BW, Benveniste MF, Madan R, Godoy MC, de Groot PM, Truong MT, Rosado-de-Christenson ML, Marom EM
Radiographics 2017 Mar-Apr;37(2):413-436. Epub 2017 Jan 27 doi: 10.1148/rg.2017160095. PMID: 28129068
Carter BW, Marom EM, Detterbeck FC
J Thorac Oncol 2014 Sep;9(9 Suppl 2):S102-9. doi: 10.1097/JTO.0000000000000294. PMID: 25396306

Therapy

Dunne EG, Fick CN, Jones DR
J Clin Oncol 2023 Aug 1;41(22):3785-3790. Epub 2023 Jun 2 doi: 10.1200/JCO.23.00867. PMID: 37267507Free PMC Article
Fan Y, Zhang AM, Wu XL, Huang ZS, Kontogianni K, Sun K, Fu WL, Wu N, Kuebler WM, Herth FJF
Lancet Respir Med 2023 Mar;11(3):256-264. Epub 2022 Oct 22 doi: 10.1016/S2213-2600(22)00392-7. PMID: 36279880
Le Pechoux C, Pourel N, Barlesi F, Lerouge D, Antoni D, Lamezec B, Nestle U, Boisselier P, Dansin E, Paumier A, Peignaux K, Thillays F, Zalcman G, Madelaine J, Pichon E, Larrouy A, Lavole A, Argo-Leignel D, Derollez M, Faivre-Finn C, Hatton MQ, Riesterer O, Bouvier-Morel E, Dunant A, Edwards JG, Thomas PA, Mercier O, Bardet A
Lancet Oncol 2022 Jan;23(1):104-114. Epub 2021 Dec 15 doi: 10.1016/S1470-2045(21)00606-9. PMID: 34919827
Savage KJ
Blood 2022 Sep 1;140(9):955-970. doi: 10.1182/blood.2020008376. PMID: 34496020
Zhang J, Guo JR, Huang ZS, Fu WL, Wu XL, Wu N, Kuebler WM, Herth FJF, Fan Y
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 9 doi: 10.1183/13993003.00055-2021. PMID: 33958432

Prognosis

Schwalk AJ, Niroula A, Schimmel M
Curr Opin Pulm Med 2024 Jan 1;30(1):25-34. Epub 2023 Oct 26 doi: 10.1097/MCP.0000000000001022. PMID: 37851368
D'Andrilli A, Maurizi G, Venuta F, Rendina EA
Gen Thorac Cardiovasc Surg 2020 Jul;68(7):725-732. Epub 2019 Dec 3 doi: 10.1007/s11748-019-01263-8. PMID: 31797211
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Stigt JA, Boers JE, Oostdijk AH, van den Berg JW, Groen HJ
J Thorac Oncol 2011 Aug;6(8):1345-9. doi: 10.1097/JTO.0b013e31821d41c8. PMID: 21587083
Herth FJ, Ernst A, Eberhardt R
Curr Opin Pulm Med 2009 Jul;15(4):308-12. doi: 10.1097/MCP.0b013e32832cbee6. PMID: 19436205

Clinical prediction guides

Tang R, Liang H, Guo Y, Li Z, Liu Z, Lin X, Yan Z, Liu J, Xu X, Shao W, Li S, Liang W, Wang W, Cui F, He H, Yang C, Jiang L, Wang H, Chen H, Guo C, Zhang H, Gao Z, He Y, Chen X, Zhao L, Yu H, Hu J, Zhao J, Li B, Yin C, Mao W, Lin W, Xie Y, Liu J, Li X, Wu D, Hou Q, Chen Y, Chen D, Xue Y, Liang Y, Tang W, Wang Q, Li E, Liu H, Wang G, Yu P, Chen C, Zheng B, Chen H, Zhang Z, Wang L, Wang A, Li Z, Fu J, Zhang G, Zhang J, Liu B, Zhao J, Deng B, Han Y, Leng X, Li Z, Zhang M, Liu C, Wang T, Luo Z, Yang C, Guo X, Ma K, Wang L, Jiang W, Han X, Wang Q, Qiao K, Xia Z, Zheng S, Xu C, Peng J, Wu S, Zhang Z, Huang H, Pang D, Liu Q, Li J, Ding X, Liu X, Zhong L, Lu Y, Xu F, Dai Q, He J
Lancet Digit Health 2023 Sep;5(9):e560-e570. doi: 10.1016/S2589-7500(23)00106-1. PMID: 37625894
Zhang J, Guo JR, Huang ZS, Fu WL, Wu XL, Wu N, Kuebler WM, Herth FJF, Fan Y
Eur Respir J 2021 Dec;58(6) Epub 2021 Dec 9 doi: 10.1183/13993003.00055-2021. PMID: 33958432
Candoli P, Ceron L, Trisolini R, Romagnoli M, Michieletto L, Scarlata S, Galasso T, Leoncini F, Pasini V, Dennetta D, Marchesani F, Zotti M, Corbetta L
Panminerva Med 2019 Sep;61(3):249-279. Epub 2018 Nov 9 doi: 10.23736/S0031-0808.18.03570-X. PMID: 30421897
Stigt JA, Boers JE, Oostdijk AH, van den Berg JW, Groen HJ
J Thorac Oncol 2011 Aug;6(8):1345-9. doi: 10.1097/JTO.0b013e31821d41c8. PMID: 21587083
Herth FJ, Ernst A, Eberhardt R
Curr Opin Pulm Med 2009 Jul;15(4):308-12. doi: 10.1097/MCP.0b013e32832cbee6. PMID: 19436205

Recent systematic reviews

Botana-Rial M, Lojo-Rodríguez I, Leiro-Fernández V, Ramos-Hernández C, González-Montaos A, Pazos-Area L, Núñez-Delgado M, Fernández-Villar A
Respir Med 2023 Nov;218:107389. Epub 2023 Aug 12 doi: 10.1016/j.rmed.2023.107389. PMID: 37579981
Buglione M, Guerini AE, Filippi AR, Spiazzi L, Pasinetti N, Magli A, Toraci C, Borghetti P, Triggiani L, Alghisi A, Costantino G, Bertagna F, Giaj Levra N, Pegurri L, Magrini SM
Crit Rev Oncol Hematol 2021 Nov;167:103437. Epub 2021 Aug 3 doi: 10.1016/j.critrevonc.2021.103437. PMID: 34358649
Gao ZY, Liu XB, Pandey S, Gao B, Liu P, Zhang QH, Gao YJ, Li SB
Int J Clin Oncol 2021 Feb;26(2):284-295. Epub 2020 Nov 20 doi: 10.1007/s10147-020-01809-4. PMID: 33216242
Watanabe A, Miyajima M, Mishina T, Tsuruta K, Takahashi Y, Maki R, Tada M
Surg Today 2017 Dec;47(12):1419-1428. Epub 2017 Mar 11 doi: 10.1007/s00595-017-1494-x. PMID: 28285463
Okholm C, Svendsen LB, Achiam MP
Surg Oncol 2014 Sep;23(3):140-6. Epub 2014 Jun 11 doi: 10.1016/j.suronc.2014.06.001. PMID: 24953457

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