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Odontogenic neoplasm

MedGen UID:: 10426
•Concept ID:: C0028880
•: Neoplastic Process

Synonyms:	Odontogenic Tumor; Odontogenic Tumors; Tumor, Odontogenic; Tumors, Odontogenic
SNOMED CT:	Odontogenic neoplasm (127578009); Odontogenic neoplasm (morphology) (127578009)

HPO:	HP:0100612
Monarch Initiative:	MONDO:0021192

Definition

Neoplasm involving odontogenic cells, an odontogenic tumor. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVOdontogenic neoplasm

Mouth disorder
- Mouth disorder
  - Mouth disorder
    - Mouth disorder
      - Mouth disorder
        Disorder of teeth AND/OR supporting structures
        Odontogenic neoplasm
        Ameloblastoma
        Benign Ameloblastoma
        Desmoplastic ameloblastoma
        Extraosseous/Peripheral Ameloblastoma
        Metastasizing Ameloblastoma
        Solid/Multicystic Ameloblastoma
        Follicular Ameloblastoma
        Plexiform ameloblastoma
        Unicystic Ameloblastoma
        Benign Odontogenic Neoplasm
        Adenomatoid odontogenic tumor
        Ameloblastic Fibro-Odontoma
        Ameloblastic Fibrodentinoma
        Ameloblastic Fibroma
        Calcifying Cystic Odontogenic Tumor
        Calcifying epithelial odontogenic tumor
        Cementoma
        Dentinogenic Ghost Cell Tumor
        Odontogenic Fibroma
        Peripheral Odontogenic Fibroma
        Odontogenic Myxofibroma
        Odontogenic Myxoma
        Ossifying fibroma
        Primordial Odontogenic Tumor
        Squamous Odontogenic Tumor
        Malignant Odontogenic Neoplasm
        Odontogenic Carcinoma
        Ameloblastic carcinoma
        Clear Cell Odontogenic Carcinoma
        Ghost Cell Odontogenic Carcinoma
        Primary intraosseous squamous cell carcinoma
        Sclerosing Odontogenic Carcinoma
        Odontogenic Carcinosarcoma
        Odontogenic Sarcoma
        Ameloblastic Fibrodentinosarcoma
        Ameloblastic Fibroodontosarcoma
        Ameloblastic Fibrosarcoma
        Odontogenic keratocysts of the jaw
        Odontoma
        Complex Odontoma
        Compound Odontoma

Professional guidelines

PubMed

Ameloblastoma: a clinical review and trends in management.

McClary AC, West RB, McClary AC, Pollack JR, Fischbein NJ, Holsinger CF, Sunwoo J, Colevas AD, Sirjani D
Eur Arch Otorhinolaryngol 2016 Jul;273(7):1649-61. Epub 2015 Apr 30 doi: 10.1007/s00405-015-3631-8. PMID: 25926124

See all (1)

Recent clinical studies

Etiology

Machine learning-based radiomics for predicting BRAF-V600E mutations in ameloblastoma.

Li W, Li Y, Liu X, Wang L, Chen W, Qian X, Zheng X, Chen J, Liu Y, Lin L
Front Immunol 2023;14:1180908. Epub 2023 Aug 14 doi: 10.3389/fimmu.2023.1180908. PMID: 37646022 Free PMC Article

Immunoexpression of BRAF, EGFR and CD10 in ameloblastoma.

Tan CC, Siar CH, Shanmuhasuntharam P
Malays J Pathol 2022 Apr;44(1):19-28. PMID: 35484883

Ameloblastoma.

Mendenhall WM, Werning JW, Fernandes R, Malyapa RS, Mendenhall NP
Am J Clin Oncol 2007 Dec;30(6):645-8. doi: 10.1097/COC.0b013e3181573e59. PMID: 18091060

Maxillary ameloblastoma.

Bozza F, Marcelli VA, Pistilli R, Govoni FA, Marsico C
Minerva Stomatol 2006 Apr;55(4):215-22. PMID: 16618996

Relative incidence of odontogenic tumors and oral and jaw cysts in a Canadian population.

Daley TD, Wysocki GP, Pringle GA
Oral Surg Oral Med Oral Pathol 1994 Mar;77(3):276-80. doi: 10.1016/0030-4220(94)90299-2. PMID: 8170660

See all (24)

Diagnosis

Ameloblastic Fibro-Odontoma.

Safavi M, Mohammadi F
Fetal Pediatr Pathol 2023 Apr;42(2):281-284. Epub 2022 Jun 24 doi: 10.1080/15513815.2022.2088910. PMID: 35748698

Sinonasal Ameloblastoma.

Barrena BG, Phillips BJ, Moran KJ, Betz SJ
Head Neck Pathol 2019 Jun;13(2):247-250. Epub 2018 May 30 doi: 10.1007/s12105-018-0933-3. PMID: 29846904 Free PMC Article

Lesions of the jaws presenting as radiolucencies on cone-beam CT.

MacDonald D
Clin Radiol 2016 Oct;71(10):972-985. Epub 2016 Jun 29 doi: 10.1016/j.crad.2016.05.018. PMID: 27371961

Ameloblastic Carcinoma.

Gunaratne DA, Coleman HG, Lim L, Morgan GJ
Am J Case Rep 2015 Jul 1;16:415-9. doi: 10.12659/AJCR.893918. PMID: 26126621 Free PMC Article

Ameloblastoma.

Mendenhall WM, Werning JW, Fernandes R, Malyapa RS, Mendenhall NP
Am J Clin Oncol 2007 Dec;30(6):645-8. doi: 10.1097/COC.0b013e3181573e59. PMID: 18091060

See all (78)

Therapy

Neoadjuvant BRAF-targeted therapy for ameloblastoma of the mandible: an organ preservation approach.

Grynberg S, Vered M, Shapira-Frommer R, Asher N, Ben-Betzalel G, Stoff R, Steinberg Y, Amariglio N, Greenberg G, Barshack I, Toren A, Yahalom R, Schachter J, Rechavi G, Hirschhorn A, Abebe Campino G
J Natl Cancer Inst 2024 Apr 5;116(4):539-546. doi: 10.1093/jnci/djad232. PMID: 37966914

Machine learning-based radiomics for predicting BRAF-V600E mutations in ameloblastoma.

Li W, Li Y, Liu X, Wang L, Chen W, Qian X, Zheng X, Chen J, Liu Y, Lin L
Front Immunol 2023;14:1180908. Epub 2023 Aug 14 doi: 10.3389/fimmu.2023.1180908. PMID: 37646022 Free PMC Article

Pattern of care and impact of prognostic factors in the outcome of ameloblastic carcinoma: a systematic review and individual patient data analysis of 199 cases.

Giridhar P, Mallick S, Upadhyay AD, Rath GK
Eur Arch Otorhinolaryngol 2017 Oct;274(10):3803-3810. Epub 2017 Jun 9 doi: 10.1007/s00405-017-4631-7. PMID: 28600599

Retrospective study of 25 cases of keratocystic odontogenic tumor: epidemiology and treatment.

Schussel JL, Stramandinoli RT, Dissenha JL, Avila LF, Sassi LM
J Contemp Dent Pract 2011 Mar 1;12(2):100-3. doi: 10.5005/jp-journals-10024-1016. PMID: 22186751

See all (4)

Prognosis

Machine learning-based radiomics for predicting BRAF-V600E mutations in ameloblastoma.

Li W, Li Y, Liu X, Wang L, Chen W, Qian X, Zheng X, Chen J, Liu Y, Lin L
Front Immunol 2023;14:1180908. Epub 2023 Aug 14 doi: 10.3389/fimmu.2023.1180908. PMID: 37646022 Free PMC Article

Sinonasal Ameloblastoma.

Barrena BG, Phillips BJ, Moran KJ, Betz SJ
Head Neck Pathol 2019 Jun;13(2):247-250. Epub 2018 May 30 doi: 10.1007/s12105-018-0933-3. PMID: 29846904 Free PMC Article

Ameloblastoma: a clinical review and trends in management.

Molecular concepts in the pathogenesis of ameloblastoma: implications for therapeutics.

Jhamb T, Kramer JM
Exp Mol Pathol 2014 Dec;97(3):345-53. Epub 2014 Sep 4 doi: 10.1016/j.yexmp.2014.09.001. PMID: 25194300

Molecular review of odontogenic myxoma.

Gomes CC, Diniz MG, Duarte AP, Bernardes VF, Gomez RS
Oral Oncol 2011 May;47(5):325-8. Epub 2011 Mar 27 doi: 10.1016/j.oraloncology.2011.03.006. PMID: 21444236

See all (28)

Clinical prediction guides

Machine learning-based radiomics for predicting BRAF-V600E mutations in ameloblastoma.

Li W, Li Y, Liu X, Wang L, Chen W, Qian X, Zheng X, Chen J, Liu Y, Lin L
Front Immunol 2023;14:1180908. Epub 2023 Aug 14 doi: 10.3389/fimmu.2023.1180908. PMID: 37646022 Free PMC Article

A conservative approach for unicystic ameloblastoma: Retrospective clinic-pathologic analysis of 12 cases.

Leite-Lima F, Martins-Chaves RR, Fonseca FP, Brennan PA, de Castro WH, Gomez RS
J Oral Pathol Med 2023 Aug;52(7):654-659. Epub 2023 May 24 doi: 10.1111/jop.13453. PMID: 37224237

Unicystic adenoid ameloblastoma: A new variant?

Martins-Chaves RR, Coura BP, Gomes CC, Fonseca FP, de Castro WH, Gomez RS
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Jul;134(1):e23-e28. Epub 2021 Oct 14 doi: 10.1016/j.oooo.2021.10.005. PMID: 35153188

BRAFV600E mutation in the diagnosis of unicystic ameloblastoma.

Pereira NB, Pereira KM, Coura BP, Diniz MG, de Castro WH, Gomes CC, Gomez RS
J Oral Pathol Med 2016 Nov;45(10):780-785. Epub 2016 Apr 15 doi: 10.1111/jop.12443. PMID: 27084044

Activating FGFR2-RAS-BRAF mutations in ameloblastoma.

Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, Elenitoba-Johnson KS, Betz BL
Clin Cancer Res 2014 Nov 1;20(21):5517-26. Epub 2014 Jul 3 doi: 10.1158/1078-0432.CCR-14-1069. PMID: 24993163

See all (24)

Recent systematic reviews

A Systematic Review of the Granular Cell Odontogenic Fibroma and Report of a New Case.

Severino Lazo RJG, Martins-de-Barros AV, da Silva Cunha J, de Paiva Macedo RA, Borges MA, Islam MN, Vasconcelos BCDE, Carvalho MV
Head Neck Pathol 2023 Sep;17(3):793-802. Epub 2023 Apr 28 doi: 10.1007/s12105-023-01553-x. PMID: 37118351 Free PMC Article

Pattern of care and impact of prognostic factors in the outcome of ameloblastic carcinoma: a systematic review and individual patient data analysis of 199 cases.

Giridhar P, Mallick S, Upadhyay AD, Rath GK
Eur Arch Otorhinolaryngol 2017 Oct;274(10):3803-3810. Epub 2017 Jun 9 doi: 10.1007/s00405-017-4631-7. PMID: 28600599

Central granular cell odontogenic tumor: a systematic review.

Sarode SC, Sarode GS, Vaidya K
J Oral Pathol Med 2014 Mar;43(3):167-76. Epub 2013 May 13 doi: 10.1111/jop.12085. PMID: 23668324

Achieving adequate margins in ameloblastoma resection: the role for intra-operative specimen imaging. Clinical report and systematic review.

De Silva I, Rozen WM, Ramakrishnan A, Mirkazemi M, Baillieu C, Ptasznik R, Leong J
PLoS One 2012;7(10):e47897. Epub 2012 Oct 19 doi: 10.1371/journal.pone.0047897. PMID: 23094099 Free PMC Article

See all (4)

MedGen

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Odontogenic neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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