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Tonsil carcinoma

MedGen UID:
107535
•Concept ID:
C0558355
•
Neoplastic Process
Synonyms: Cancer of the Tonsil; Cancer of Tonsil; Carcinoma of the Tonsil; carcinoma of the tonsil; Carcinoma of Tonsil; carcinoma of tonsil; Tonsil Cancer; Tonsil Carcinoma; tonsil carcinoma; Tonsillar Cancer; Tonsillar Carcinoma; tonsillar carcinoma
SNOMED CT: Tonsil carcinoma (274085008)
 
Monarch Initiative: MONDO:0021337

Definition

A carcinoma arising from the tonsilar epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTonsil carcinoma

Professional guidelines

PubMed

Unilateral radiotherapy for the treatment of tonsil cancer.
Chronowski GM, Garden AS, Morrison WH, Frank SJ, Schwartz DL, Shah SJ, Beadle BM, Gunn GB, Kupferman ME, Ang KK, Rosenthal DI
Int J Radiat Oncol Biol Phys 2012 May 1;83(1):204-9. Epub 2011 Oct 20 doi: 10.1016/j.ijrobp.2011.06.1975. PMID: 22019242
Primary surgery as treatment for early squamous cell carcinoma of the tonsil.
Galati LT, Myers EN, Johnson JT
Head Neck 2000 May;22(3):294-6. doi: 10.1002/(sici)1097-0347(200005)22:3<294::aid-hed13>3.0.co;2-9. PMID: 10748454
Tonsil carcinoma--treatment results.
Quenelle DJ, Crissman JD, Shumrick DA
Laryngoscope 1979 Nov;89(11):1842-6. doi: 10.1288/00005537-197911000-00019. PMID: 502706

Recent clinical studies

Etiology

Involvement of KLRK1 in immune infiltration of head and neck squamous cell carcinoma correlates with favorable prognosis.
Tan H, Yang H, Qian J, Liu S, Yan D, Wei L, Liu W
Medicine (Baltimore) 2023 Aug 11;102(32):e34761. doi: 10.1097/MD.0000000000034761. PMID: 37565867Free PMC Article
TNF-α evaluation in tonsil cancer.
Turculeanu A, Mogoantă CA, IoniŢă E, Avrămescu CS, Afrem MC, Costache A
Rom J Morphol Embryol 2015;56(1):101-6. PMID: 25826493
Unilateral radiotherapy for the treatment of tonsil cancer.
Chronowski GM, Garden AS, Morrison WH, Frank SJ, Schwartz DL, Shah SJ, Beadle BM, Gunn GB, Kupferman ME, Ang KK, Rosenthal DI
Int J Radiat Oncol Biol Phys 2012 May 1;83(1):204-9. Epub 2011 Oct 20 doi: 10.1016/j.ijrobp.2011.06.1975. PMID: 22019242
Head and neck squamous cell carcinoma in the young: a spectrum or a distinct group? Part 1.
Toner M, O'Regan EM
Head Neck Pathol 2009 Sep;3(3):246-8. Epub 2009 Aug 19 doi: 10.1007/s12105-009-0135-0. PMID: 20596979Free PMC Article
Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years.
Shiboski CH, Schmidt BL, Jordan RC
Cancer 2005 May 1;103(9):1843-9. doi: 10.1002/cncr.20998. PMID: 15772957

Diagnosis

Does pTis exist in HPV-driven tonsillar carcinomas? An ultrastructural review and examination of two cases.
Black CC, Ogomo C
Ultrastruct Pathol 2017 Jan-Feb;41(1):55-61. Epub 2016 Dec 6 doi: 10.1080/01913123.2016.1258020. PMID: 27922337
The Impact of Tonsillectomy upon the Risk of Oropharyngeal Carcinoma Diagnosis and Prognosis in the Danish Cancer Registry.
Fakhry C, Andersen KK, Christensen J, Agrawal N, Eisele DW
Cancer Prev Res (Phila) 2015 Jul;8(7):583-9. Epub 2015 Apr 20 doi: 10.1158/1940-6207.CAPR-15-0101. PMID: 25896236Free PMC Article
TNF-α evaluation in tonsil cancer.
Turculeanu A, Mogoantă CA, IoniŢă E, Avrămescu CS, Afrem MC, Costache A
Rom J Morphol Embryol 2015;56(1):101-6. PMID: 25826493
Unilateral radiotherapy for the treatment of tonsil cancer.
Chronowski GM, Garden AS, Morrison WH, Frank SJ, Schwartz DL, Shah SJ, Beadle BM, Gunn GB, Kupferman ME, Ang KK, Rosenthal DI
Int J Radiat Oncol Biol Phys 2012 May 1;83(1):204-9. Epub 2011 Oct 20 doi: 10.1016/j.ijrobp.2011.06.1975. PMID: 22019242
Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years.
Shiboski CH, Schmidt BL, Jordan RC
Cancer 2005 May 1;103(9):1843-9. doi: 10.1002/cncr.20998. PMID: 15772957

Therapy

Re-evaluation of Ipsilateral Radiation for T1-T2N0-N2b Tonsil Carcinoma at the Princess Margaret Hospital in the Human Papillomavirus Era, 25 Years Later.
Huang SH, Waldron J, Bratman SV, Su J, Kim J, Bayley A, Cho J, Giuliani M, Hope A, Ringash J, Hansen A, de Almeida JR, Goldstein D, Perez-Ordonez B, Weinreb I, Tong L, Xu W, O'Sullivan B
Int J Radiat Oncol Biol Phys 2017 May 1;98(1):159-169. Epub 2017 Jan 9 doi: 10.1016/j.ijrobp.2017.01.018. PMID: 28258895
Hyoid osteoradionecrosis accompanied by candida infection.
Yavaş G, Kara Gedik G, Çolpan B, Ata Ö, Öztürk K, Sarı O
Kulak Burun Bogaz Ihtis Derg 2015;25(5):310-4. doi: 10.5606/kbbihtisas.2015.59219. PMID: 26476522
KRAS-mutation positive, metastatic tonsil carcinoma with cancer stem-like cell features and long-term response to gefitinib: a case report and review of the literature.
Gottschling S, Penzel R, Pelz T, Herpel E, Schnabel PA, Dyckhoff G, Thomas M, Kuhnt T
J Clin Oncol 2011 Jul 20;29(21):e616-9. Epub 2011 May 9 doi: 10.1200/JCO.2011.34.5892. PMID: 21555681
Transoral robotic photodynamic therapy for the oropharynx.
Quon H, Finlay J, Cengel K, Zhu T, O'Malley B Jr, Weinstein G
Photodiagnosis Photodyn Ther 2011 Mar;8(1):64-7. Epub 2011 Jan 15 doi: 10.1016/j.pdpdt.2010.12.005. PMID: 21333937Free PMC Article
Targeted intra-arterial chemoradiation for advanced tonsil cancer.
Naidu SI, Vieira F, Samant S, Vang MC, Wan AY, Robbins TK
Otolaryngol Head Neck Surg 2005 Dec;133(6):882-7. doi: 10.1016/j.otohns.2005.08.014. PMID: 16360508

Prognosis

Involvement of KLRK1 in immune infiltration of head and neck squamous cell carcinoma correlates with favorable prognosis.
Tan H, Yang H, Qian J, Liu S, Yan D, Wei L, Liu W
Medicine (Baltimore) 2023 Aug 11;102(32):e34761. doi: 10.1097/MD.0000000000034761. PMID: 37565867Free PMC Article
Does pTis exist in HPV-driven tonsillar carcinomas? An ultrastructural review and examination of two cases.
Black CC, Ogomo C
Ultrastruct Pathol 2017 Jan-Feb;41(1):55-61. Epub 2016 Dec 6 doi: 10.1080/01913123.2016.1258020. PMID: 27922337
The Impact of Tonsillectomy upon the Risk of Oropharyngeal Carcinoma Diagnosis and Prognosis in the Danish Cancer Registry.
Fakhry C, Andersen KK, Christensen J, Agrawal N, Eisele DW
Cancer Prev Res (Phila) 2015 Jul;8(7):583-9. Epub 2015 Apr 20 doi: 10.1158/1940-6207.CAPR-15-0101. PMID: 25896236Free PMC Article
Unilateral radiotherapy for the treatment of tonsil cancer.
Chronowski GM, Garden AS, Morrison WH, Frank SJ, Schwartz DL, Shah SJ, Beadle BM, Gunn GB, Kupferman ME, Ang KK, Rosenthal DI
Int J Radiat Oncol Biol Phys 2012 May 1;83(1):204-9. Epub 2011 Oct 20 doi: 10.1016/j.ijrobp.2011.06.1975. PMID: 22019242
Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years.
Shiboski CH, Schmidt BL, Jordan RC
Cancer 2005 May 1;103(9):1843-9. doi: 10.1002/cncr.20998. PMID: 15772957

Clinical prediction guides

Does pTis exist in HPV-driven tonsillar carcinomas? An ultrastructural review and examination of two cases.
Black CC, Ogomo C
Ultrastruct Pathol 2017 Jan-Feb;41(1):55-61. Epub 2016 Dec 6 doi: 10.1080/01913123.2016.1258020. PMID: 27922337
TNF-α evaluation in tonsil cancer.
Turculeanu A, Mogoantă CA, IoniŢă E, Avrămescu CS, Afrem MC, Costache A
Rom J Morphol Embryol 2015;56(1):101-6. PMID: 25826493
Long-term outcome analysis after surgical salvage for recurrent tonsil carcinoma following radical radiotherapy.
Bachar GY, Goh C, Goldstein DP, O'Sullivan B, Irish JC
Eur Arch Otorhinolaryngol 2010 Feb;267(2):295-301. doi: 10.1007/s00405-009-1070-0. PMID: 19756684
Incidental head and neck (18)F-FDG uptake on PET/CT without corresponding morphological lesion: early predictor of cancer development?
Heusner TA, Hahn S, Hamami ME, Kögel S, Forsting M, Bockisch A, Antoch G, Stahl AR
Eur J Nucl Med Mol Imaging 2009 Sep;36(9):1397-406. Epub 2009 Mar 21 doi: 10.1007/s00259-009-1113-1. PMID: 19305995

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