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Thyroid gland carcinoma

MedGen UID:
107811
Concept ID:
C0549473
Neoplastic Process
Synonym: Thyroid carcinoma
 
HPO: HP:0002890
Monarch Initiative: MONDO:0015075
Orphanet: ORPHA100088

Definition

The presence of a carcinoma of the thyroid gland. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Thyroid gland carcinoma in Orphanet.

Conditions with this feature

Pendred syndrome
MedGen UID:
82890
Concept ID:
C0271829
Disease or Syndrome
Pendred syndrome / nonsyndromic enlarged vestibular aqueduct (PDS/NSEVA) comprises a phenotypic spectrum of sensorineural hearing loss (SNHL) that is usually congenital and often severe to profound (although mild-to-moderate progressive hearing impairment also occurs), vestibular dysfunction, and temporal bone abnormalities (bilateral enlarged vestibular aqueduct with or without cochlear hypoplasia). PDS also includes development of euthyroid goiter in late childhood to early adulthood whereas NSEVA does not.
Iodotyrosyl coupling defect
MedGen UID:
90976
Concept ID:
C0342194
Disease or Syndrome
Kanou et al. (2007) reviewed characteristics of thyroid dyshormonogenesis caused by mutations in the thyroglobulin (TG) gene. This form of thyroid dyshormonogenesis has an estimated prevalence of one in 100,000 newborns. Inherited in an autosomal recessive manner, the disorder in the majority of patients causes large goiters of elastic and soft consistency. Although the degree of thyroid dysfunction varies considerably among patients with defective TG synthesis, patients usually have a relatively high serum free T3 concentration with disproportionately low free T4 level. The maintenance of relatively high FT3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Carney complex, type 1
MedGen UID:
388559
Concept ID:
C2607929
Disease or Syndrome
Carney complex (CNC) is characterized by skin pigmentary abnormalities, myxomas, endocrine tumors or overactivity, and schwannomas. Pale brown to black lentigines are the most common presenting feature of CNC and typically increase in number at puberty. Cardiac myxomas occur at a young age, may occur in any or all cardiac chambers, and can manifest as intracardiac obstruction of blood flow, embolic phenomenon, and/or heart failure. Other sites for myxomas include the skin, breast, oropharynx, and female genital tract. Primary pigmented nodular adrenocortical disease (PPNAD), which causes Cushing syndrome, is the most frequently observed endocrine tumor in CNC, occurring in approximately 25% of affected individuals. Large-cell calcifying Sertoli cell tumors (LCCSCTs) are observed in one third of affected males within the first decade and in most adult males. Up to 75% of individuals with CNC have multiple thyroid nodules, most of which are nonfunctioning thyroid follicular adenomas. Clinically evident acromegaly from a growth hormone (GH)-producing adenoma is evident in approximately 10% of adults. Psammomatous melanotic schwannoma (PMS), a rare tumor of the nerve sheath, occurs in an estimated 10% of affected individuals. The median age of diagnosis is 20 years.

Professional guidelines

PubMed

Durante C, Hegedüs L, Czarniecka A, Paschke R, Russ G, Schmitt F, Soares P, Solymosi T, Papini E
Eur Thyroid J 2023 Oct 1;12(5) Epub 2023 Aug 14 doi: 10.1530/ETJ-23-0067. PMID: 37358008Free PMC Article
De Almeida R, McCalmon S, Cabandugama PK
Mo Med 2022 Jul-Aug;119(4):366-371. PMID: 36118802Free PMC Article
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Thyroid Carcinoma, 2024

Recent clinical studies

Etiology

Abbas J, Wienke A, Spielmann RP, Bach AG, Surov A
Eur J Radiol 2013 Sep;82(9):1423-30. Epub 2013 Jun 3 doi: 10.1016/j.ejrad.2013.04.032. PMID: 23743051
Surov A, Hainz M, Holzhausen HJ, Arnold D, Katzer M, Schmidt J, Spielmann RP, Behrmann C
Eur Radiol 2010 Mar;20(3):649-58. Epub 2009 Aug 26 doi: 10.1007/s00330-009-1577-1. PMID: 19707767
Ahmad T, Naeem M, Ahmad S, Samad A, Nasir A
J Ayub Med Coll Abbottabad 2008 Jul-Sep;20(3):30-2. PMID: 19610510
Karner I, Hrgović Z, Sijanović S, Buković D, Klobucar A, Usadel KH, Fassbender WJ
Eur J Med Res 2005 Nov 16;10(11):480-8. PMID: 16354602
Zbären P, Nuyens M, Thoeny HC, Stauffer E
Am J Surg 2005 Jul;190(1):153-5. doi: 10.1016/j.amjsurg.2005.04.009. PMID: 15972190

Diagnosis

Abbas J, Wienke A, Spielmann RP, Bach AG, Surov A
Eur J Radiol 2013 Sep;82(9):1423-30. Epub 2013 Jun 3 doi: 10.1016/j.ejrad.2013.04.032. PMID: 23743051
Bago-Rožanković P, Bašić S, Vavro H, Rožanković M, Nikolić I, Muller D, Grahovac G
Int J Surg Pathol 2013 Aug;21(4):390-3. Epub 2013 Jan 24 doi: 10.1177/1066896912473353. PMID: 23349474
Surov A, Hainz M, Holzhausen HJ, Arnold D, Katzer M, Schmidt J, Spielmann RP, Behrmann C
Eur Radiol 2010 Mar;20(3):649-58. Epub 2009 Aug 26 doi: 10.1007/s00330-009-1577-1. PMID: 19707767
Ahmad T, Naeem M, Ahmad S, Samad A, Nasir A
J Ayub Med Coll Abbottabad 2008 Jul-Sep;20(3):30-2. PMID: 19610510
Zbären P, Nuyens M, Thoeny HC, Stauffer E
Am J Surg 2005 Jul;190(1):153-5. doi: 10.1016/j.amjsurg.2005.04.009. PMID: 15972190

Therapy

Karner I, Hrgović Z, Sijanović S, Buković D, Klobucar A, Usadel KH, Fassbender WJ
Eur J Med Res 2005 Nov 16;10(11):480-8. PMID: 16354602
Zbären P, Nuyens M, Thoeny HC, Stauffer E
Am J Surg 2005 Jul;190(1):153-5. doi: 10.1016/j.amjsurg.2005.04.009. PMID: 15972190
Sijanovic S, Karner I
Medscape Womens Health 2001 Oct;6(5):3. PMID: 11698925
Segal K, Sidi J, Levy R, Abraham A
Ann Otol Rhinol Laryngol 1985 Jul-Aug;94(4 Pt 1):346-9. PMID: 4026119
van der Giessen PH, Bierhuizen H
Strahlentherapie 1980 Apr;156(4):275-6. PMID: 7368236

Prognosis

Caasi JMN, Baldoza RIDG, Bauzon MSC, Odtohan MAF, Santiago LA, Santiago-Bautista MR
Asian Pac J Cancer Prev 2023 Aug 1;24(8):2601-2614. doi: 10.31557/APJCP.2023.24.8.2601. PMID: 37642045Free PMC Article
Čolović Z, Ivanišević P, Bulat C, Barić A, Kontić M, Punda H, Poljak NK, Punda A
Acta Clin Croat 2020 Jun;59(Suppl 1):149-152. doi: 10.20471/acc.2020.59.s1.20. PMID: 34219898Free PMC Article
Bago-Rožanković P, Bašić S, Vavro H, Rožanković M, Nikolić I, Muller D, Grahovac G
Int J Surg Pathol 2013 Aug;21(4):390-3. Epub 2013 Jan 24 doi: 10.1177/1066896912473353. PMID: 23349474
Zbären P, Nuyens M, Thoeny HC, Stauffer E
Am J Surg 2005 Jul;190(1):153-5. doi: 10.1016/j.amjsurg.2005.04.009. PMID: 15972190
Segal K, Sidi J, Levy R, Abraham A
Ann Otol Rhinol Laryngol 1985 Jul-Aug;94(4 Pt 1):346-9. PMID: 4026119

Clinical prediction guides

Caasi JMN, Baldoza RIDG, Bauzon MSC, Odtohan MAF, Santiago LA, Santiago-Bautista MR
Asian Pac J Cancer Prev 2023 Aug 1;24(8):2601-2614. doi: 10.31557/APJCP.2023.24.8.2601. PMID: 37642045Free PMC Article
Karner I, Hrgović Z, Sijanović S, Buković D, Klobucar A, Usadel KH, Fassbender WJ
Eur J Med Res 2005 Nov 16;10(11):480-8. PMID: 16354602
Zbären P, Nuyens M, Thoeny HC, Stauffer E
Am J Surg 2005 Jul;190(1):153-5. doi: 10.1016/j.amjsurg.2005.04.009. PMID: 15972190
Sijanovic S, Karner I
Medscape Womens Health 2001 Oct;6(5):3. PMID: 11698925

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Thyroid Carcinoma, 2024

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