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Upbeat nystagmus

MedGen UID:
107943
Concept ID:
C0585545
Finding; Finding
Synonyms: Upbeat central nystagmus; Upbeat central vestibular nystagmus
SNOMED CT: Upbeat nystagmus (307677002); Upbeat central nystagmus (307677002); Upbeat central vestibular nystagmus (307677002)
 
HPO: HP:0011477

Definition

In primary position, the eyes drift slowly downward and then spontaneously beat upward. Upward gaze accentuates the nystagmus. The associated oscillopsias are often very irritating, but the symptoms are usually transient. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUpbeat nystagmus

Professional guidelines

PubMed

Mehta AR, Kennard C
Pract Neurol 2012 Jun;12(3):147-53. doi: 10.1136/practneurol-2011-000181. PMID: 22661344
Straube A, Bronstein A, Straumann D; European Federation of Neurologic Societies
Eur J Neurol 2012 Jan;19(1):6-14. Epub 2011 Sep 12 doi: 10.1111/j.1468-1331.2011.03503.x. PMID: 21906211
Brandt T, Zwergal A, Strupp M
Expert Opin Pharmacother 2009 Jul;10(10):1537-48. doi: 10.1517/14656560902976879. PMID: 19527184

Recent clinical studies

Etiology

Strupp M, Kremmyda O, Brandt T
Semin Neurol 2013 Jul;33(3):286-96. Epub 2013 Sep 21 doi: 10.1055/s-0033-1354594. PMID: 24057832
Strupp M, Thurtell MJ, Shaikh AG, Brandt T, Zee DS, Leigh RJ
J Neurol 2011 Jul;258(7):1207-22. Epub 2011 Apr 2 doi: 10.1007/s00415-011-5999-8. PMID: 21461686Free PMC Article
Pierrot-Deseilligny C
Ann N Y Acad Sci 2009 May;1164:155-65. doi: 10.1111/j.1749-6632.2009.03864.x. PMID: 19645894
Kumar A, Patni AH, Charbel F
Otol Neurotol 2002 Sep;23(5):727-35. doi: 10.1097/00129492-200209000-00021. PMID: 12218627
Elliott AJ, Simpson EM, Oakhill A, Decock R
Dev Med Child Neurol 1989 Feb;31(1):43-6. doi: 10.1111/j.1469-8749.1989.tb08410.x. PMID: 2920872

Diagnosis

Strupp ML, Straumann D, Helmchen C
Klin Monbl Augenheilkd 2021 Nov;238(11):1186-1195. Epub 2021 Nov 16 doi: 10.1055/a-1525-0030. PMID: 34784642
Kincade M
J Binocul Vis Ocul Motil 2019 Jul-Sep;69(3):98-101. doi: 10.1080/2576117X.2019.1622969. PMID: 31329055
Strupp M, Kremmyda O, Brandt T
Semin Neurol 2013 Jul;33(3):286-96. Epub 2013 Sep 21 doi: 10.1055/s-0033-1354594. PMID: 24057832
Strupp M, Hüfner K, Sandmann R, Zwergal A, Dieterich M, Jahn K, Brandt T
Dtsch Arztebl Int 2011 Mar;108(12):197-204. Epub 2011 Mar 25 doi: 10.3238/arztebl.2011.0197. PMID: 21505601Free PMC Article
Brandt T, Dieterich M
J Vestib Res 1993 Spring;3(1):3-14. PMID: 8275242

Therapy

Zhu W, Steenerson KK, Kattah JC
J Neurol 2023 Mar;270(3):1713-1720. Epub 2022 Dec 15 doi: 10.1007/s00415-022-11514-z. PMID: 36520241
Kalla R, Teufel J, Feil K, Muth C, Strupp M
J Neurol 2016 Apr;263 Suppl 1:S24-9. Epub 2016 Apr 15 doi: 10.1007/s00415-015-7987-x. PMID: 27083881Free PMC Article
Mehta AR, Kennard C
Pract Neurol 2012 Jun;12(3):147-53. doi: 10.1136/practneurol-2011-000181. PMID: 22661344
Brandt T, Zwergal A, Strupp M
Expert Opin Pharmacother 2009 Jul;10(10):1537-48. doi: 10.1517/14656560902976879. PMID: 19527184
Straube A, Leigh RJ, Bronstein A, Heide W, Riordan-Eva P, Tijssen CC, Dehaene I, Straumann D
Eur J Neurol 2004 Feb;11(2):83-9. doi: 10.1046/j.1468-1331.2003.00754.x. PMID: 14748767

Prognosis

Strupp M, Kremmyda O, Adamczyk C, Böttcher N, Muth C, Yip CW, Bremova T
J Neurol 2014 Sep;261 Suppl 2(Suppl 2):S542-58. doi: 10.1007/s00415-014-7385-9. PMID: 25145891Free PMC Article
Brandt T, Zwergal A, Strupp M
Expert Opin Pharmacother 2009 Jul;10(10):1537-48. doi: 10.1517/14656560902976879. PMID: 19527184
Fattal-Valevski A, Kesler A, Sela BA, Nitzan-Kaluski D, Rotstein M, Mesterman R, Toledano-Alhadef H, Stolovitch C, Hoffmann C, Globus O, Eshel G
Pediatrics 2005 Feb;115(2):e233-8. doi: 10.1542/peds.2004-1255. PMID: 15687431
Rousseaux M, Dupard T, Lesoin F, Barbaste P, Hache JC
J Neurol Neurosurg Psychiatry 1991 Apr;54(4):367-9. doi: 10.1136/jnnp.54.4.367. PMID: 2056325Free PMC Article
Elliott AJ, Simpson EM, Oakhill A, Decock R
Dev Med Child Neurol 1989 Feb;31(1):43-6. doi: 10.1111/j.1469-8749.1989.tb08410.x. PMID: 2920872

Clinical prediction guides

Califano L, Mazzone S, Salafia F, Melillo MG, Manna G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):255-262. doi: 10.14639/0392-100X-N1032. PMID: 34264919Free PMC Article
Zheng Y, Wu S, Yang X
Acta Otolaryngol 2021 May;141(5):433-439. Epub 2021 Feb 9 doi: 10.1080/00016489.2021.1876247. PMID: 33557660
Mustafa MM, Akram H, Oliva-Domínguez M, Kaski D
J Neurol 2020 Nov;267(11):3425-3428. Epub 2020 Jul 15 doi: 10.1007/s00415-020-10071-7. PMID: 32671528Free PMC Article
Pierrot-Deseilligny C
Ann N Y Acad Sci 2009 May;1164:155-65. doi: 10.1111/j.1749-6632.2009.03864.x. PMID: 19645894
Brandt T, Dieterich M
J Vestib Res 1993 Spring;3(1):3-14. PMID: 8275242

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