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Hot flashes

MedGen UID:
109378
•Concept ID:
C0600142
•
Sign or Symptom
Synonyms: Flashes, Hot; Hot Flashes
SNOMED CT: Hot flush (198436008); Hot flashes (198436008); Hot flushes (198436008); Climacteric flushing (427368007); Menopausal hot flashes (198436008); Menopausal flushing (198436008); Menopausal hot flushes (198436008)
 
HPO: HP:0031217

Definition

Sudden feelings of warmth that are generally most pronounced over the face, neck and chest. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHot flashes

Professional guidelines

PubMed

Management of Menopausal Symptoms: A Review.
Crandall CJ, Mehta JM, Manson JE
JAMA 2023 Feb 7;329(5):405-420. doi: 10.1001/jama.2022.24140. PMID: 36749328
Management of the Perimenopause.
Delamater L, Santoro N
Clin Obstet Gynecol 2018 Sep;61(3):419-432. doi: 10.1097/GRF.0000000000000389. PMID: 29952797Free PMC Article
Menopausal Symptoms and Their Management.
Santoro N, Epperson CN, Mathews SB
Endocrinol Metab Clin North Am 2015 Sep;44(3):497-515. doi: 10.1016/j.ecl.2015.05.001. PMID: 26316239Free PMC Article

Recent clinical studies

Etiology

Management of perimenopausal and menopausal symptoms.
Duralde ER, Sobel TH, Manson JE
BMJ 2023 Aug 8;382:e072612. doi: 10.1136/bmj-2022-072612. PMID: 37553173
Menopause.
McNeil MA, Merriam SB
Ann Intern Med 2021 Jul;174(7):ITC97-ITC112. Epub 2021 Jul 13 doi: 10.7326/AITC202107200. PMID: 34251902
Risks, Benefits, and Treatment Modalities of Menopausal Hormone Therapy: Current Concepts.
Mehta J, Kling JM, Manson JE
Front Endocrinol (Lausanne) 2021;12:564781. Epub 2021 Mar 26 doi: 10.3389/fendo.2021.564781. PMID: 33841322Free PMC Article
The Menopause Transition: Signs, Symptoms, and Management Options.
Santoro N, Roeca C, Peters BA, Neal-Perry G
J Clin Endocrinol Metab 2021 Jan 1;106(1):1-15. doi: 10.1210/clinem/dgaa764. PMID: 33095879
Menopause.
Davis SR, Lambrinoudaki I, Lumsden M, Mishra GD, Pal L, Rees M, Santoro N, Simoncini T
Nat Rev Dis Primers 2015 Apr 23;1:15004. doi: 10.1038/nrdp.2015.4. PMID: 27188659

Diagnosis

Menopause.
McNeil MA, Merriam SB
Ann Intern Med 2021 Jul;174(7):ITC97-ITC112. Epub 2021 Jul 13 doi: 10.7326/AITC202107200. PMID: 34251902
The Menopause Transition: Signs, Symptoms, and Management Options.
Santoro N, Roeca C, Peters BA, Neal-Perry G
J Clin Endocrinol Metab 2021 Jan 1;106(1):1-15. doi: 10.1210/clinem/dgaa764. PMID: 33095879
Vasomotor Symptoms Across the Menopause Transition: Differences Among Women.
Avis NE, Crawford SL, Green R
Obstet Gynecol Clin North Am 2018 Dec;45(4):629-640. Epub 2018 Oct 25 doi: 10.1016/j.ogc.2018.07.005. PMID: 30401547Free PMC Article
Sex-Specific Physiology and Cardiovascular Disease.
Shufelt CL, Pacheco C, Tweet MS, Miller VM
Adv Exp Med Biol 2018;1065:433-454. doi: 10.1007/978-3-319-77932-4_27. PMID: 30051400Free PMC Article
Menopausal Symptoms and Their Management.
Santoro N, Epperson CN, Mathews SB
Endocrinol Metab Clin North Am 2015 Sep;44(3):497-515. doi: 10.1016/j.ecl.2015.05.001. PMID: 26316239Free PMC Article

Therapy

Hormone replacement therapy after breast cancer: Yes, No or maybe?
Ugras SK, Layeequr Rahman R
Mol Cell Endocrinol 2021 Apr 5;525:111180. Epub 2021 Jan 26 doi: 10.1016/j.mce.2021.111180. PMID: 33508379
The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?
Miller VM, Naftolin F, Asthana S, Black DM, Brinton EA, Budoff MJ, Cedars MI, Dowling NM, Gleason CE, Hodis HN, Jayachandran M, Kantarci K, Lobo RA, Manson JE, Pal L, Santoro NF, Taylor HS, Harman SM
Menopause 2019 Sep;26(9):1071-1084. doi: 10.1097/GME.0000000000001326. PMID: 31453973Free PMC Article
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 28093732Free PMC Article
Black cohosh (Cimicifuga spp.) for menopausal symptoms.
Leach MJ, Moore V
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD007244. doi: 10.1002/14651858.CD007244.pub2. PMID: 22972105Free PMC Article
Menopause.
Nelson HD
Lancet 2008 Mar 1;371(9614):760-70. doi: 10.1016/S0140-6736(08)60346-3. PMID: 18313505

Prognosis

Insomnia and hot flashes.
Bonanni E, Schirru A, Di Perri MC, Bonuccelli U, Maestri M
Maturitas 2019 Aug;126:51-54. Epub 2019 May 14 doi: 10.1016/j.maturitas.2019.05.001. PMID: 31239118
Symptoms of menopause - global prevalence, physiology and implications.
Monteleone P, Mascagni G, Giannini A, Genazzani AR, Simoncini T
Nat Rev Endocrinol 2018 Apr;14(4):199-215. Epub 2018 Feb 2 doi: 10.1038/nrendo.2017.180. PMID: 29393299
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 28093732Free PMC Article
Menopause.
Davis SR, Lambrinoudaki I, Lumsden M, Mishra GD, Pal L, Rees M, Santoro N, Simoncini T
Nat Rev Dis Primers 2015 Apr 23;1:15004. doi: 10.1038/nrdp.2015.4. PMID: 27188659
Menopause.
Takahashi TA, Johnson KM
Med Clin North Am 2015 May;99(3):521-34. doi: 10.1016/j.mcna.2015.01.006. PMID: 25841598

Clinical prediction guides

The Menopause Transition: Signs, Symptoms, and Management Options.
Santoro N, Roeca C, Peters BA, Neal-Perry G
J Clin Endocrinol Metab 2021 Jan 1;106(1):1-15. doi: 10.1210/clinem/dgaa764. PMID: 33095879
Insomnia and hot flashes.
Bonanni E, Schirru A, Di Perri MC, Bonuccelli U, Maestri M
Maturitas 2019 Aug;126:51-54. Epub 2019 May 14 doi: 10.1016/j.maturitas.2019.05.001. PMID: 31239118
Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis.
Franco OH, Chowdhury R, Troup J, Voortman T, Kunutsor S, Kavousi M, Oliver-Williams C, Muka T
JAMA 2016 Jun 21;315(23):2554-63. doi: 10.1001/jama.2016.8012. PMID: 27327802
Menopause.
Davis SR, Lambrinoudaki I, Lumsden M, Mishra GD, Pal L, Rees M, Santoro N, Simoncini T
Nat Rev Dis Primers 2015 Apr 23;1:15004. doi: 10.1038/nrdp.2015.4. PMID: 27188659
Menopause.
Takahashi TA, Johnson KM
Med Clin North Am 2015 May;99(3):521-34. doi: 10.1016/j.mcna.2015.01.006. PMID: 25841598

Recent systematic reviews

The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review.
Feduniw S, Korczyńska L, Górski K, Zgliczyńska M, Bączkowska M, Byrczak M, Kociuba J, Ali M, Ciebiera M
Nutrients 2022 Dec 29;15(1) doi: 10.3390/nu15010160. PMID: 36615817Free PMC Article
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 28093732Free PMC Article
Hormone Therapy and Other Treatments for Symptoms of Menopause.
Hill DA, Crider M, Hill SR
Am Fam Physician 2016 Dec 1;94(11):884-889. PMID: 27929271
Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis.
Franco OH, Chowdhury R, Troup J, Voortman T, Kunutsor S, Kavousi M, Oliver-Williams C, Muka T
JAMA 2016 Jun 21;315(23):2554-63. doi: 10.1001/jama.2016.8012. PMID: 27327802
Black cohosh (Cimicifuga spp.) for menopausal symptoms.
Leach MJ, Moore V
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD007244. doi: 10.1002/14651858.CD007244.pub2. PMID: 22972105Free PMC Article

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