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Soft tissue neoplasm

MedGen UID:
11495
•Concept ID:
C0037579
•
Neoplastic Process
Synonyms: Neoplasm, Soft Tissue; Neoplasms, Soft Tissue; Soft Tissue Neoplasm; Soft Tissue Neoplasms
SNOMED CT: Neoplasm of soft tissue (387837005); Soft tissue tumor (387837005); Tumor of soft tissue (387837005); Neoplasm of soft tissues (387837005)
 
HPO: HP:0031459
Monarch Initiative: MONDO:0006424

Definition

A tumor (abnormal growth of tissue) that arises from the soft tissue. The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSoft tissue neoplasm

Professional guidelines

PubMed

INternational Soft Tissue saRcoma ConsorTium (INSTRuCT) consensus statement: Imaging recommendations for the management of rhabdomyosarcoma.
Schoot RA, van Ewijk R, von Witzleben AA, Kao SC, Merks JHMH, Morosi C, Pace E, Shulkin BL, Ferrari A, von Kalle T, van Rijn RR, Weiss AR, Sparber-Sauer M, Ter Horst SAJ, McCarville MB
Eur J Radiol 2023 Sep;166:111012. Epub 2023 Jul 25 doi: 10.1016/j.ejrad.2023.111012. PMID: 37541182
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis.
Schneider N, Fisher C, Thway K
Ann Diagn Pathol 2016 Feb;20:52-8. Epub 2015 Dec 2 doi: 10.1016/j.anndiagpath.2015.11.002. PMID: 26732302

Recent clinical studies

Etiology

INternational Soft Tissue saRcoma ConsorTium (INSTRuCT) consensus statement: Imaging recommendations for the management of rhabdomyosarcoma.
Schoot RA, van Ewijk R, von Witzleben AA, Kao SC, Merks JHMH, Morosi C, Pace E, Shulkin BL, Ferrari A, von Kalle T, van Rijn RR, Weiss AR, Sparber-Sauer M, Ter Horst SAJ, McCarville MB
Eur J Radiol 2023 Sep;166:111012. Epub 2023 Jul 25 doi: 10.1016/j.ejrad.2023.111012. PMID: 37541182
Ultrasound-Guided Moving Shot Radiofrequency Ablation of Benign Soft Tissue Neoplasm.
Lin WC, Tai YF, Chen MH, Luo SD, Huang F, Chen WC, Chiang PL, Chen HL, Chen MH, Baek JH
Medicina (Kaunas) 2021 Aug 17;57(8) doi: 10.3390/medicina57080830. PMID: 34441036Free PMC Article
Angiomatoid fibrous histiocytoma: the current status of pathology and genetics.
Thway K, Fisher C
Arch Pathol Lab Med 2015 May;139(5):674-82. doi: 10.5858/arpa.2014-0234-RA. PMID: 25927151
World Health Organization classification of bone and soft tissue tumors: modifications and implications for radiologists.
Murphey MD
Semin Musculoskelet Radiol 2007 Sep;11(3):201-14. doi: 10.1055/s-2008-1038310. PMID: 18260031
Soft tissue sarcomas in dermatology.
Fish FS
Dermatol Surg 1996 Mar;22(3):268-73. doi: 10.1111/j.1524-4725.1996.tb00318.x. PMID: 8599739

Diagnosis

INternational Soft Tissue saRcoma ConsorTium (INSTRuCT) consensus statement: Imaging recommendations for the management of rhabdomyosarcoma.
Schoot RA, van Ewijk R, von Witzleben AA, Kao SC, Merks JHMH, Morosi C, Pace E, Shulkin BL, Ferrari A, von Kalle T, van Rijn RR, Weiss AR, Sparber-Sauer M, Ter Horst SAJ, McCarville MB
Eur J Radiol 2023 Sep;166:111012. Epub 2023 Jul 25 doi: 10.1016/j.ejrad.2023.111012. PMID: 37541182
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Soft tissue tumor diagnosis: A three prong approach utilizing pattern analysis, immunocytochemistry, and molecular diagnostics.
Layfield LJ
Diagn Cytopathol 2020 Mar;48(3):265-284. Epub 2019 Dec 23 doi: 10.1002/dc.24355. PMID: 31868988
Current Update on Desmoid Fibromatosis.
Ganeshan D, Amini B, Nikolaidis P, Assing M, Vikram R
J Comput Assist Tomogr 2019 Jan-Feb;43(1):29-38. doi: 10.1097/RCT.0000000000000790. PMID: 30211798Free PMC Article
Primary Tumors of the Foot and Ankle.
Kennedy JG, Ross KA, Smyth NA, Hogan MV, Murawski CD
Foot Ankle Spec 2016 Feb;9(1):58-68. Epub 2015 Dec 7 doi: 10.1177/1938640015620634. PMID: 26644034

Therapy

The Notch signaling pathway in desmoid tumor: Recent advances and the therapeutic prospects.
Zheng C, Huang J, Xu G, Li W, Weng X, Zhang S
Biochim Biophys Acta Mol Basis Dis 2024 Jan;1870(1):166907. Epub 2023 Oct 2 doi: 10.1016/j.bbadis.2023.166907. PMID: 37793461
Subcutaneous entomophthoromycosis masquerading as soft tissue neoplasm in breastfeeding mother.
Venkataramana CG, Rama Krishna Reddy MM, Kalbavi HR, Joseph JA
BMJ Case Rep 2023 Aug 27;16(8) doi: 10.1136/bcr-2023-255623. PMID: 37640413Free PMC Article
Clinical trials in desmoid-type fibromatosis in children and adults: A systematic review.
van Maren SA, van Noesel MM, Husson O, van der Graaf WTA
Pediatr Blood Cancer 2022 Sep;69(9):e29831. Epub 2022 Jul 9 doi: 10.1002/pbc.29831. PMID: 35714333
Molecular Pathogenesis of Sporadic Desmoid Tumours and Its Implications for Novel Therapies: A Systematised Narrative Review.
McLean TD, Duchi S, Di Bella C
Target Oncol 2022 May;17(3):223-252. Epub 2022 Apr 21 doi: 10.1007/s11523-022-00876-z. PMID: 35446005Free PMC Article
Novel enriched pathways in superficial malignant peripheral nerve sheath tumours and spindle/desmoplastic melanomas.
Jour G, Andeen NK, Al-Rohil R, Aung PP, Mehrotra M, Duose D, Hoch B, Argenyi Z, Luthra R, Wistuba II, Prieto VG
J Pathol 2018 Jan;244(1):97-106. doi: 10.1002/path.4996. PMID: 28991373

Prognosis

Keratin-positive giant cell-rich tumors of soft tissue with HMGA2::NCOR2 fusions.
Weigelt MA, Azzato EM, Habermehl GK, Billings SD, Ko JS, Fritchie KJ
J Cutan Pathol 2023 Nov;50(11):977-982. Epub 2023 Jul 26 doi: 10.1111/cup.14497. PMID: 37496152
Osteolipoma of head and neck - a review.
Wong BLK, Hogan C
Braz J Otorhinolaryngol 2022 Nov-Dec;88 Suppl 4(Suppl 4):S177-S187. Epub 2022 May 20 doi: 10.1016/j.bjorl.2022.04.002. PMID: 35659712Free PMC Article
A Review of Effusion Cytomorphology of Small Round Cell Tumors.
Han LM, VandenBussche CJ, Abildtrup M, Chandra A, Vohra P
Acta Cytol 2022;66(4):336-346. Epub 2021 Jul 2 doi: 10.1159/000516497. PMID: 34218227
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Rhabdomyosarcoma in children - current pathologic and molecular classification.
Dziuba I, Kurzawa P, Dopierała M, Larque AB, Januszkiewicz-Lewandowska D
Pol J Pathol 2018;69(1):20-32. doi: 10.5114/pjp.2018.75333. PMID: 29895123

Clinical prediction guides

Extraenteric Malignant Gastrointestinal Neuroectodermal Tumor-A Clinicopathologic and Molecular Genetic Study of 11 Cases.
Ulici V, Hornick JL, Davis JL, Mehrotra S, Meis JM, Halling KC, Fletcher CDM, Kao E, Folpe AL
Mod Pathol 2023 Jul;36(7):100160. Epub 2023 Mar 17 doi: 10.1016/j.modpat.2023.100160. PMID: 36934861
GAB1::ABL1 fusions define a distinctive soft tissue neoplasm, with variable perineurial differentiation, and a predilection for children and young adults.
Agaimy A, Perret R, Demicco EG, Gross J, Liu YJ, Azmani R, Engelmann C, Schubart C, Seppet J, Stoehr R, Le Loarer F, Dickson BC
Genes Chromosomes Cancer 2023 Aug;62(8):449-459. Epub 2023 Feb 21 doi: 10.1002/gcc.23131. PMID: 36744864
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Rhabdomyosarcoma in children - current pathologic and molecular classification.
Dziuba I, Kurzawa P, Dopierała M, Larque AB, Januszkiewicz-Lewandowska D
Pol J Pathol 2018;69(1):20-32. doi: 10.5114/pjp.2018.75333. PMID: 29895123
Soft tissue sarcomas in dermatology.
Fish FS
Dermatol Surg 1996 Mar;22(3):268-73. doi: 10.1111/j.1524-4725.1996.tb00318.x. PMID: 8599739

Recent systematic reviews

Pleomorphic Rhabdomyosarcoma: A Systematic Review with Outcome Analysis and Report of a Rare Abdominal Wall Lesion.
Deb PQ, Chokshi RJ, Li S, Suster DI
Int J Surg Pathol 2023 Aug;31(5):548-556. Epub 2022 Jun 16 doi: 10.1177/10668969221105622. PMID: 35707991
Clinical trials in desmoid-type fibromatosis in children and adults: A systematic review.
van Maren SA, van Noesel MM, Husson O, van der Graaf WTA
Pediatr Blood Cancer 2022 Sep;69(9):e29831. Epub 2022 Jul 9 doi: 10.1002/pbc.29831. PMID: 35714333

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