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Dysgraphia

MedGen UID:
115942
Concept ID:
C0234144
Mental or Behavioral Dysfunction
Synonym: Dysgraphia (disease)
SNOMED CT: Dysgraphia (88278002)
 
HPO: HP:0010526
Monarch Initiative: MONDO:0003038

Definition

A writing disability in the absence of motor or sensory deficits of the upper extremities, resulting in an impairment in the ability to write regardless of the ability to read and not due to intellectual impairment. [from HPO]

Conditions with this feature

Spinocerebellar ataxia type 21
MedGen UID:
375311
Concept ID:
C1843891
Disease or Syndrome
Spinocerebellar ataxia-21 (SCA21) is an autosomal dominant neurologic disorder characterized by onset in the first decades of life of slowly progressive cerebellar ataxia, which is associated with cognitive impairment in most patients (summary by Delplanque et al., 2014). For a general discussion of autosomal dominant spinocerebellar ataxia, see SCA1 (164400).
Tolchin-Le Caignec syndrome
MedGen UID:
1724999
Concept ID:
C5436509
Disease or Syndrome
Tolchin-Le Caignec syndrome (TOLCAS) is a developmental disorder characterized by mildly to moderately impaired intellectual development and behavioral problems, such as autism, ADHD, labile mood, and aggressive episodes. Many patients have bony abnormalities, including osteochondroma, craniosynostosis, dysmorphic facies, arachnodactyly, and large head circumference. Rarely, additional congenital anomalies may also be observed. These additional features and the bony defects are highly variable (summary by Tolchin et al., 2020).

Professional guidelines

PubMed

Chung WK, Herrera FF; Simon's Searchlight Foundation
Cold Spring Harb Mol Case Stud 2023 Dec;9(4) Epub 2024 Jan 10 doi: 10.1101/mcs.a006316. PMID: 38050025Free PMC Article
Orsini A, Foiadelli T, Magistrali M, Carli N, Bagnasco I, Dassi P, Verrotti A, Marcotulli D, Canavese C, Nicita F, Capuano A, Marra C, Fetta A, Nosadini M, Sartori S, Papa A, Viri M, Greco F, Pavone P, Simonini G, Matricardi S, Siquilini S, Marchese F, De Grandis E, Brunenghi BM, Malattia C, Bassanese F, Bergonzini P, Bonuccelli A, Consolini R, Marseglia GL, Peroni D, Striano P, Cordelli D, Savasta S
Eur J Paediatr Neurol 2022 Jan;36:1-6. Epub 2021 Nov 6 doi: 10.1016/j.ejpn.2021.11.002. PMID: 34768201
Krajenbrink T, Nickels L, Kohnen S
Neuropsychol Rehabil 2015;25(4):503-54. Epub 2014 Nov 18 doi: 10.1080/09602011.2014.983135. PMID: 25403342

Recent clinical studies

Etiology

Tee BL, Lorinda Kwan-Chen LY, Chen TF, Yan CTY, Tsoh J, Lung-Tat Chan A, Wong A, Lo RY, Lu CL, Wang PN, Lee Y, Yang FG, Battistella G, Allen IE, Dronkers NF, Miller BL, Gorno-Tempini ML
Neurology 2022 May 31;98(22):e2245-e2257. Epub 2022 Apr 11 doi: 10.1212/WNL.0000000000200350. PMID: 35410909Free PMC Article
Curtin MJ, Willis DR, Enneking B
Am Fam Physician 2019 Nov 15;100(10):628-635. PMID: 31730315
Guerrini R, Melani F, Brancati C, Ferrari AR, Brovedani P, Biggeri A, Grisotto L, Pellacani S
PLoS One 2015;10(7):e0130883. Epub 2015 Jul 1 doi: 10.1371/journal.pone.0130883. PMID: 26132164Free PMC Article
Rapcsak SZ, Beeson PM, Henry ML, Leyden A, Kim E, Rising K, Andersen S, Cho H
Cortex 2009 May;45(5):575-91. Epub 2008 Jun 5 doi: 10.1016/j.cortex.2008.04.006. PMID: 18625494Free PMC Article
Gubbay SS, de Klerk NH
Brain Dev 1995 Jan-Feb;17(1):1-8. doi: 10.1016/0387-7604(94)00110-j. PMID: 7539228

Diagnosis

G S A, Ponniah RJ
J Psycholinguist Res 2023 Dec;52(6):2903-2917. Epub 2023 Nov 6 doi: 10.1007/s10936-023-10029-6. PMID: 37930468
Drotár P, Dobeš M
Sci Rep 2020 Dec 9;10(1):21541. doi: 10.1038/s41598-020-78611-9. PMID: 33299092Free PMC Article
Markiewcz R
Psychiatr Pol 2017 Dec 30;51(6):1095-1106. doi: 10.12740/PP/68919. PMID: 29432505
Letanneux A, Danna J, Velay JL, Viallet F, Pinto S
Mov Disord 2014 Oct;29(12):1467-75. Epub 2014 Aug 22 doi: 10.1002/mds.25990. PMID: 25156696
Quillen TF, Gladstone K
Nursing 2008 May;38(5):26. doi: 10.1097/01.NURSE.0000317668.40925.d8. PMID: 18431188

Therapy

Yuen C, Rezania K, Kelly T, Bishop MR
Immunotherapy 2021 Oct;13(15):1261-1269. Epub 2021 Sep 24 doi: 10.2217/imt-2021-0084. PMID: 34558978
Marshall J, Caute A, Chadd K, Cruice M, Monnelly K, Wilson S, Woolf C
Int J Lang Commun Disord 2019 Mar;54(2):203-220. Epub 2018 May 10 doi: 10.1111/1460-6984.12391. PMID: 29749112
Thiel L, Conroy P
Neuropsychol Rehabil 2014;24(2):172-201. Epub 2014 Feb 12 doi: 10.1080/09602011.2013.875925. PMID: 24517315
Nandhagopal R, Al-Asmi A, Johnston WJ, Jacob PC, Arunodaya GR
J Neurol Sci 2012 Mar 15;314(1-2):178-80. Epub 2011 Nov 8 doi: 10.1016/j.jns.2011.10.007. PMID: 22075046
Macleod AD, Whitehead LE
Palliat Med 1997 Mar;11(2):127-32. doi: 10.1177/026921639701100206. PMID: 9156108

Prognosis

Bublin M, Werner F, Kerschbaumer A, Korak G, Geyer S, Rettinger L, Schönthaler E, Schmid-Kietreiber M
Sensors (Basel) 2023 May 31;23(11) doi: 10.3390/s23115215. PMID: 37299942Free PMC Article
Drotár P, Dobeš M
Sci Rep 2020 Dec 9;10(1):21541. doi: 10.1038/s41598-020-78611-9. PMID: 33299092Free PMC Article
Gargot T, Asselborn T, Pellerin H, Zammouri I, M Anzalone S, Casteran L, Johal W, Dillenbourg P, Cohen D, Jolly C
PLoS One 2020;15(9):e0237575. Epub 2020 Sep 11 doi: 10.1371/journal.pone.0237575. PMID: 32915793Free PMC Article
Tal-Saban M, Weintraub N
Res Dev Disabil 2019 Nov;94:103479. Epub 2019 Sep 10 doi: 10.1016/j.ridd.2019.103479. PMID: 31518720
Rapcsak SZ, Beeson PM, Henry ML, Leyden A, Kim E, Rising K, Andersen S, Cho H
Cortex 2009 May;45(5):575-91. Epub 2008 Jun 5 doi: 10.1016/j.cortex.2008.04.006. PMID: 18625494Free PMC Article

Clinical prediction guides

Tee BL, Lorinda Kwan-Chen LY, Chen TF, Yan CTY, Tsoh J, Lung-Tat Chan A, Wong A, Lo RY, Lu CL, Wang PN, Lee Y, Yang FG, Battistella G, Allen IE, Dronkers NF, Miller BL, Gorno-Tempini ML
Neurology 2022 May 31;98(22):e2245-e2257. Epub 2022 Apr 11 doi: 10.1212/WNL.0000000000200350. PMID: 35410909Free PMC Article
Drotár P, Dobeš M
Sci Rep 2020 Dec 9;10(1):21541. doi: 10.1038/s41598-020-78611-9. PMID: 33299092Free PMC Article
Gargot T, Asselborn T, Pellerin H, Zammouri I, M Anzalone S, Casteran L, Johal W, Dillenbourg P, Cohen D, Jolly C
PLoS One 2020;15(9):e0237575. Epub 2020 Sep 11 doi: 10.1371/journal.pone.0237575. PMID: 32915793Free PMC Article
Rapcsak SZ, Beeson PM, Henry ML, Leyden A, Kim E, Rising K, Andersen S, Cho H
Cortex 2009 May;45(5):575-91. Epub 2008 Jun 5 doi: 10.1016/j.cortex.2008.04.006. PMID: 18625494Free PMC Article
PeBenito R, Fisch CB, Fisch ML
Arch Neurol 1988 Sep;45(9):977-82. doi: 10.1001/archneur.1988.00520330063011. PMID: 3415528

Recent systematic reviews

Vico R, Martín J, González M
Am J Occup Ther 2023 Sep 1;77(5) doi: 10.5014/ajot.2023.050174. PMID: 37877571
Biddau F, Brisotto C, Innocenti T, Ranaldi S, Meneghello F, D'Imperio D, Nordio S
Am J Speech Lang Pathol 2023 Mar 9;32(2):762-785. Epub 2023 Mar 1 doi: 10.1044/2022_AJSLP-22-00042. PMID: 36857041
van Ierschot F, Bastiaanse R, Miceli G
Neuropsychol Rev 2018 Dec;28(4):470-495. Epub 2018 Dec 21 doi: 10.1007/s11065-018-9391-7. PMID: 30578451
Markiewcz R
Psychiatr Pol 2017 Dec 30;51(6):1095-1106. doi: 10.12740/PP/68919. PMID: 29432505

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