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Disorder of testis

MedGen UID:
11743
•Concept ID:
C0039584
•
Disease or Syndrome
Synonyms: Testicular disease; Testicular disorder
SNOMED CT: Disorder of testis (64910008); Testicular disorder (64910008); Testicular disease (236763001)
 
Monarch Initiative: MONDO:0002329

Definition

A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of testis

Professional guidelines

PubMed

Advances in diagnosis and treatment of testicular cancer.
Chovanec M, Cheng L
BMJ 2022 Nov 28;379:e070499. doi: 10.1136/bmj-2022-070499. PMID: 36442868
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

High risk and low prevalence diseases: Testicular torsion.
Lacy A, Smith A, Koyfman A, Long B
Am J Emerg Med 2023 Apr;66:98-104. Epub 2023 Jan 24 doi: 10.1016/j.ajem.2023.01.031. PMID: 36738571
When to ask for an MRI of the scrotum.
Tsili AC, Argyropoulou MI, Dolciami M, Ercolani G, Catalano C, Manganaro L
Andrology 2021 Sep;9(5):1395-1409. Epub 2021 Jun 11 doi: 10.1111/andr.13032. PMID: 33964115Free PMC Article
Cryptorchidism.
Lee PA, Houk CP
Curr Opin Endocrinol Diabetes Obes 2013 Jun;20(3):210-6. doi: 10.1097/MED.0b013e32835ffc7d. PMID: 23493040
Scrotal calculi.
Artas H, Orhan I
J Ultrasound Med 2007 Dec;26(12):1775-9. doi: 10.7863/jum.2007.26.12.1775. PMID: 18029930
Testicular injuries.
Cass AS, Luxenberg M
Urology 1991 Jun;37(6):528-30. doi: 10.1016/0090-4295(91)80317-z. PMID: 2038785

Diagnosis

High risk and low prevalence diseases: Testicular torsion.
Lacy A, Smith A, Koyfman A, Long B
Am J Emerg Med 2023 Apr;66:98-104. Epub 2023 Jan 24 doi: 10.1016/j.ajem.2023.01.031. PMID: 36738571
Male infertility due to testicular disorders.
Sharma A, Minhas S, Dhillo WS, Jayasena CN
J Clin Endocrinol Metab 2021 Jan 23;106(2):e442-e459. doi: 10.1210/clinem/dgaa781. PMID: 33295608Free PMC Article
Scrotal Ultrasound.
Rebik K, Wagner JM, Middleton W
Radiol Clin North Am 2019 May;57(3):635-648. Epub 2019 Feb 14 doi: 10.1016/j.rcl.2019.01.007. PMID: 30928082
Cryptorchidism.
Lee PA, Houk CP
Curr Opin Endocrinol Diabetes Obes 2013 Jun;20(3):210-6. doi: 10.1097/MED.0b013e32835ffc7d. PMID: 23493040
Paratesticular tumor-like lesions.
Oliva E, Young RH
Semin Diagn Pathol 2000 Nov;17(4):340-58. PMID: 11202549

Therapy

Pearls and perils in the management of germ cell tumors.
Wei CX, Einhorn LH, Adra N
Curr Opin Oncol 2021 May 1;33(3):206-211. doi: 10.1097/CCO.0000000000000718. PMID: 33577208
Atypical testicular pain.
Bedi N, Rahimi MNC, Menzies S, Kalsi J
BMJ Case Rep 2019 Feb 19;12(2) doi: 10.1136/bcr-2018-226697. PMID: 30787023Free PMC Article
The undescended testis.
MacKinnon AE
Indian J Pediatr 2005 May;72(5):429-32. doi: 10.1007/BF02731742. PMID: 15973027
Maldescendus testis.
Toppari J, Kaleva M
Horm Res 1999 Dec;51(6):261-9. doi: 10.1159/000023412. PMID: 10640886
Henoch-Schönlein purpura.
Robson WL, Leung AK
Adv Pediatr 1994;41:163-94. PMID: 7992683

Prognosis

Treatment and follow-up of rare testis tumours.
Fankhauser CD, Grogg JB, Rothermundt C, Clarke NW
J Cancer Res Clin Oncol 2022 Mar;148(3):667-671. Epub 2022 Jan 20 doi: 10.1007/s00432-021-03890-2. PMID: 35048196
Cryptorchidism.
Hutson JM, Balic A, Nation T, Southwell B
Semin Pediatr Surg 2010 Aug;19(3):215-24. doi: 10.1053/j.sempedsurg.2010.04.001. PMID: 20610195
Maldescendus testis.
Toppari J, Kaleva M
Horm Res 1999 Dec;51(6):261-9. doi: 10.1159/000023412. PMID: 10640886
Testicular cancer.
Kinkade S
Am Fam Physician 1999 May 1;59(9):2539-44, 2549-50. PMID: 10323360
Henoch-Schönlein purpura.
Robson WL, Leung AK
Adv Pediatr 1994;41:163-94. PMID: 7992683

Clinical prediction guides

Testicular Dysfunction in 47,XXY Boys: When It All Begins. A Semilongitudinal Study.
Pozza C, Sesti F, Tenuta M, Spaziani M, Tarantino C, Carlomagno F, Minnetti M, Pofi R, Paparella R, Lenzi A, Radicioni A, Isidori AM, Tarani L, Gianfrilli D
J Clin Endocrinol Metab 2023 Sep 18;108(10):2486-2499. doi: 10.1210/clinem/dgad205. PMID: 37043499Free PMC Article
High risk and low prevalence diseases: Testicular torsion.
Lacy A, Smith A, Koyfman A, Long B
Am J Emerg Med 2023 Apr;66:98-104. Epub 2023 Jan 24 doi: 10.1016/j.ajem.2023.01.031. PMID: 36738571
Treatment and follow-up of rare testis tumours.
Fankhauser CD, Grogg JB, Rothermundt C, Clarke NW
J Cancer Res Clin Oncol 2022 Mar;148(3):667-671. Epub 2022 Jan 20 doi: 10.1007/s00432-021-03890-2. PMID: 35048196
Male infertility.
Chow V, Cheung AP
J Reprod Med 2006 Mar;51(3):149-56. PMID: 16674008
Maldescendus testis.
Toppari J, Kaleva M
Horm Res 1999 Dec;51(6):261-9. doi: 10.1159/000023412. PMID: 10640886

Recent systematic reviews

The impact of testicular cancer and its treatment on masculinity: A systematic review.
Dax V, Ftanou M, Tran B, Lewin J, Wallace R, Seidler Z, Wiley JF
Psychooncology 2022 Sep;31(9):1459-1473. Epub 2022 Jul 21 doi: 10.1002/pon.5994. PMID: 35789023Free PMC Article
Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis.
Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC
Am J Obstet Gynecol 2022 Sep;227(3):414-429.e17. Epub 2022 Mar 30 doi: 10.1016/j.ajog.2022.03.052. PMID: 35367190
KRAS and BRAF Mutations in Stage II and III Colon Cancer: A Systematic Review and Meta-Analysis.
Formica V, Sera F, Cremolini C, Riondino S, Morelli C, Arkenau HT, Roselli M
J Natl Cancer Inst 2022 Apr 11;114(4):517-527. doi: 10.1093/jnci/djab190. PMID: 34542636Free PMC Article
Physical activity and risk of testicular cancer: a systematic review.
Huang S, Signal V, Sarfati D, Shaw C, Stanley J, McGlynn K, Gurney J
BMC Cancer 2018 Feb 14;18(1):189. doi: 10.1186/s12885-018-4093-3. PMID: 29444652Free PMC Article
Epidemiology of mesothelioma of the pericardium and tunica vaginalis testis.
Mezei G, Chang ET, Mowat FS, Moolgavkar SH
Ann Epidemiol 2017 May;27(5):348-359.e11. Epub 2017 Apr 14 doi: 10.1016/j.annepidem.2017.04.001. PMID: 28527639

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