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Uremia

MedGen UID:
12008
Concept ID:
C0041948
Disease or Syndrome
Synonym: Uremias
SNOMED CT: Uremia (44730006)
 
Monarch Initiative: MONDO:0007008

Definition

A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of renal insufficiency. Most uremic toxins are end products of protein or nitrogen catabolism, such as urea or creatinine. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms. [from MONDO]

Professional guidelines

PubMed

Stollings JL, Kotfis K, Chanques G, Pun BT, Pandharipande PP, Ely EW
Intensive Care Med 2021 Oct;47(10):1089-1103. Epub 2021 Aug 16 doi: 10.1007/s00134-021-06503-1. PMID: 34401939Free PMC Article
Galindo RJ, Beck RW, Scioscia MF, Umpierrez GE, Tuttle KR
Endocr Rev 2020 Oct 1;41(5):756-74. doi: 10.1210/endrev/bnaa017. PMID: 32455432Free PMC Article
Drew DA, Weiner DE, Sarnak MJ
Am J Kidney Dis 2019 Dec;74(6):782-790. Epub 2019 Aug 1 doi: 10.1053/j.ajkd.2019.05.017. PMID: 31378643Free PMC Article

Recent clinical studies

Etiology

Zhu L, Tong G, Yang F, Zhao Y, Chen G
Front Immunol 2022;13:1013562. Epub 2022 Sep 15 doi: 10.3389/fimmu.2022.1013562. PMID: 36189322Free PMC Article
Rosner MH, Husain-Syed F, Reis T, Ronco C, Vanholder R
Kidney Int 2022 Feb;101(2):227-241. Epub 2021 Nov 1 doi: 10.1016/j.kint.2021.09.025. PMID: 34736971
Sazgar M
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105651. Epub 2021 Feb 10 doi: 10.1016/j.jstrokecerebrovasdis.2021.105651. PMID: 33581988
Tonelli M, Karumanchi SA, Thadhani R
Circulation 2016 Feb 2;133(5):518-36. doi: 10.1161/CIRCULATIONAHA.115.018713. PMID: 26831434
Wanner C, Drechsler C, Krane V
Semin Dial 2009 Jul-Aug;22(4):438-41. doi: 10.1111/j.1525-139X.2009.00596.x. PMID: 19708997

Diagnosis

Rosner MH, Husain-Syed F, Reis T, Ronco C, Vanholder R
Kidney Int 2022 Feb;101(2):227-241. Epub 2021 Nov 1 doi: 10.1016/j.kint.2021.09.025. PMID: 34736971
Títoff V, Moury HN, Títoff IB, Kelly KM
Am J Kidney Dis 2019 Jan;73(1):90-101. Epub 2018 May 18 doi: 10.1053/j.ajkd.2018.03.021. PMID: 29784616
Baluarte JH
Semin Pediatr Neurol 2017 Feb;24(1):25-32. Epub 2016 Dec 23 doi: 10.1016/j.spen.2016.12.004. PMID: 28779862
Scherer JS, Combs SA, Brennan F
Am J Kidney Dis 2017 Jan;69(1):117-128. Epub 2016 Sep 29 doi: 10.1053/j.ajkd.2016.07.031. PMID: 27693261Free PMC Article
Meyer TW, Hostetter TH
N Engl J Med 2007 Sep 27;357(13):1316-25. doi: 10.1056/NEJMra071313. PMID: 17898101

Therapy

Rosner MH, Husain-Syed F, Reis T, Ronco C, Vanholder R
Kidney Int 2022 Feb;101(2):227-241. Epub 2021 Nov 1 doi: 10.1016/j.kint.2021.09.025. PMID: 34736971
Romagnoli S, Ricci Z, Ronco C
Curr Opin Crit Care 2018 Dec;24(6):483-492. doi: 10.1097/MCC.0000000000000544. PMID: 30239411
Ravani P, Bertelli E, Gill S, Ghiggeri GM
Nephrol Dial Transplant 2017 Jan 1;32(suppl_1):i7-i13. doi: 10.1093/ndt/gfw235. PMID: 28391333
Bakris GL
Contrib Nephrol 2012;178:100-105. Epub 2012 May 25 doi: 10.1159/000337821. PMID: 22652724
Feramisco JD, Berger TG, Steinhoff M
Dermatol Clin 2010 Jul;28(3):467-78. doi: 10.1016/j.det.2010.03.004. PMID: 20510757

Prognosis

Chugh S, Singh J, Kichloo A, Gupta S, Katchi T, Solanki S
Cardiol Rev 2021 Nov-Dec 01;29(6):310-313. doi: 10.1097/CRD.0000000000000381. PMID: 33337656
Drew DA, Weiner DE, Sarnak MJ
Am J Kidney Dis 2019 Dec;74(6):782-790. Epub 2019 Aug 1 doi: 10.1053/j.ajkd.2019.05.017. PMID: 31378643Free PMC Article
Lockwood MB, Chung S, Puzantian H, Bronas UG, Ryan CJ, Park C, DeVon HA
West J Nurs Res 2019 Jul;41(7):1056-1091. Epub 2018 Oct 31 doi: 10.1177/0193945918808766. PMID: 30378466
Rehman KA, Betancor J, Xu B, Kumar A, Rivas CG, Sato K, Wong LP, Asher CR, Klein AL
Clin Cardiol 2017 Oct;40(10):839-846. Epub 2017 Sep 5 doi: 10.1002/clc.22770. PMID: 28873222Free PMC Article
Thumfart J, Pommer W, Querfeld U, Müller D
Dtsch Arztebl Int 2014 Apr 4;111(14):237-43. doi: 10.3238/arztebl.2014.0237. PMID: 24766711Free PMC Article

Clinical prediction guides

Sazgar M
J Stroke Cerebrovasc Dis 2021 Sep;30(9):105651. Epub 2021 Feb 10 doi: 10.1016/j.jstrokecerebrovasdis.2021.105651. PMID: 33581988
Fishbane S, Jamal A, Munera C, Wen W, Menzaghi F; KALM-1 Trial Investigators
N Engl J Med 2020 Jan 16;382(3):222-232. Epub 2019 Nov 8 doi: 10.1056/NEJMoa1912770. PMID: 31702883
Baluarte JH
Semin Pediatr Neurol 2017 Feb;24(1):25-32. Epub 2016 Dec 23 doi: 10.1016/j.spen.2016.12.004. PMID: 28779862
Wanner C, Drechsler C, Krane V
Semin Dial 2009 Jul-Aug;22(4):438-41. doi: 10.1111/j.1525-139X.2009.00596.x. PMID: 19708997
Van Laecke S, De Wilde K, Vanholder R
Artif Organs 2006 Aug;30(8):579-85. doi: 10.1111/j.1525-1594.2006.00266.x. PMID: 16911311

Recent systematic reviews

Monteiro EB, Ajackson M, Stockler-Pinto MB, Guebre-Egziabher F, Daleprane JB, Soulage CO
Life Sci 2023 Jun 1;322:121664. Epub 2023 Apr 5 doi: 10.1016/j.lfs.2023.121664. PMID: 37023957
Badiee Aval S, Ravanshad Y, Azarfar A, Mehrad-Majd H, Torabi S, Ravanshad S
Iran J Kidney Dis 2018 Mar;12(2):78-83. PMID: 29507269
Simonsen E, Komenda P, Lerner B, Askin N, Bohm C, Shaw J, Tangri N, Rigatto C
Am J Kidney Dis 2017 Nov;70(5):638-655. Epub 2017 Jul 15 doi: 10.1053/j.ajkd.2017.05.018. PMID: 28720208
Kaltsatou A, Karatzaferi C, Mitrou GI, Poulianiti KP, Sakkas GK
Curr Pharm Des 2016;22(24):3700-14. doi: 10.2174/1381612822666160322144936. PMID: 27000827
Cavagnolli G, Pimentel AL, Freitas PA, Gross JL, Camargo JL
Clin Chim Acta 2015 May 20;445:107-14. Epub 2015 Mar 27 doi: 10.1016/j.cca.2015.03.024. PMID: 25818244

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