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Onychomadesis

MedGen UID:
120483
Concept ID:
C0263540
Finding
Synonyms: Complete nail loss; Loss of nails; Nail loss
SNOMED CT: OHM - Onychomadesis (22743000); Spontaneous shedding of nail from nail matrix (22743000); Onychomadesis (22743000); Complete loss of nails (22743000)
 
HPO: HP:0025088

Definition

Complete shedding (separation) of the nail from the proximal matrix. Onychomadesis is the proximal separation of the nail plate from the nail matrix due to a temporary cessation of nail growth. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOnychomadesis

Conditions with this feature

Psoriasis 1, susceptibility to
MedGen UID:
357279
Concept ID:
C1867449
Finding
Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age (summary by Matthews et al., 1996). Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (123260) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris; however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013). Nestle et al. (2009) provided a detailed review of the pathogenesis and genetics of psoriasis. Genetic Heterogeneity of Psoriasis and Psoriasis Susceptibility PSORS2 (602723) is caused by mutation in the CARD14 gene (607211) on chromosome 17q25, and PSORS14 (614204) is caused by mutation in the IL36RN gene (605507) on chromosome 2q14. Psoriasis susceptibility loci include PSORS1 on 6p21.3; PSORS3 (601454) on 4q; PSORS4 on 1q21; PSORS5 (604316) on 3q21; PSORS6 (605364) on 19p; PSORS7 (605606) on 1p; PSORS8 (610707) on 16q; PSORS9 (607857) on 4q31; PSORS10 (612410) on 18p11; PSORS11 (612599) on 5q31-q33; PSORS12 (612950) on 20q13; PSORS13 (614070), conferred by variation in the TRAF3IP2 gene (607043) on 6q21; and PSORS15 (616106), conferred by variation in the AP1S3 gene (615781) on 2q36. An additional putative psoriasis candidate locus has been reported on 20p (Nair et al., 1997).
Epidermolysis bullosa simplex 2C, localized
MedGen UID:
1794221
Concept ID:
C5562011
Disease or Syndrome
Epidermolysis bullosa simplex (EBS) is characterized by fragility of the skin (and mucosal epithelia in some instances) that results in non-scarring blisters and erosions caused by minor mechanical trauma. EBS is distinguished from other types of epidermolysis bullosa (EB) or non-EB skin fragility syndromes by the location of the blistering in relation to the dermal-epidermal junction. In EBS, blistering occurs within basal keratinocytes. The severity of blistering ranges from limited to hands and feet to widespread involvement. Additional features can include hyperkeratosis of the palms and soles (keratoderma), nail dystrophy, milia, and hyper- and/or hypopigmentation. Rare EBS subtypes have been associated with additional clinical features including pyloric atresia, muscular dystrophy, cardiomyopathy, and/or nephropathy.

Professional guidelines

PubMed

Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Litaiem N, Drissi H, Zeglaoui F, Khachemoune A
Arch Dermatol Res 2019 Sep;311(7):505-512. Epub 2019 May 10 doi: 10.1007/s00403-019-01925-w. PMID: 31076847
Chu DH, Rubin AI
Pediatr Clin North Am 2014 Apr;61(2):293-308. Epub 2014 Jan 21 doi: 10.1016/j.pcl.2013.11.005. PMID: 24636647

Recent clinical studies

Etiology

Leung AKC, Lam JM, Barankin B, Leong KF, Hon KL
Recent Adv Inflamm Allergy Drug Discov 2022;16(2):77-95. doi: 10.2174/1570180820666221024095837. PMID: 36284392
Smith RJ, Rubin AI
Curr Opin Pediatr 2020 Aug;32(4):506-515. doi: 10.1097/MOP.0000000000000921. PMID: 32692049
Justino MCA, da S Mesquita D, Souza MF, Farias FP, Dos S Alves JC, Ferreira JL, Lopes DP, Tavares FN
J Clin Virol 2020 May;126:104307. Epub 2020 Mar 6 doi: 10.1016/j.jcv.2020.104307. PMID: 32302950
Li A, Li Y, Ge L, Li P, Li W
Drug Des Devel Ther 2017;11:2373-2376. Epub 2017 Aug 14 doi: 10.2147/DDDT.S139643. PMID: 28860708Free PMC Article
Apalla Z, Sotiriou E, Pikou O, Lefaki I, Lallas A, Lazaridou E, Ioannides D
Int J Dermatol 2015 Sep;54(9):1039-44. Epub 2015 Mar 13 doi: 10.1111/ijd.12592. PMID: 25772385

Diagnosis

Arun Babu T, Nagendran P
BMJ Case Rep 2023 Dec 6;16(12) doi: 10.1136/bcr-2023-257235. PMID: 38056926Free PMC Article
Leung AKC, Lam JM, Barankin B, Leong KF, Hon KL
Recent Adv Inflamm Allergy Drug Discov 2022;16(2):77-95. doi: 10.2174/1570180820666221024095837. PMID: 36284392
Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Salgado F, Handler MZ, Schwartz RA
Cutis 2017 Jan;99(1):33-36. PMID: 28207011
Apalla Z, Sotiriou E, Pikou O, Lefaki I, Lallas A, Lazaridou E, Ioannides D
Int J Dermatol 2015 Sep;54(9):1039-44. Epub 2015 Mar 13 doi: 10.1111/ijd.12592. PMID: 25772385

Therapy

Yanagida N, Takahagi S, Tanaka A, Hide M
Acta Derm Venereol 2022 Aug 24;102:adv00763. doi: 10.2340/actadv.v102.2690. PMID: 35971830Free PMC Article
Li A, Li Y, Ge L, Li P, Li W
Drug Des Devel Ther 2017;11:2373-2376. Epub 2017 Aug 14 doi: 10.2147/DDDT.S139643. PMID: 28860708Free PMC Article
Robert C, Sibaud V, Mateus C, Verschoore M, Charles C, Lanoy E, Baran R
Lancet Oncol 2015 Apr;16(4):e181-9. doi: 10.1016/S1470-2045(14)71133-7. PMID: 25846098
Serratos BD, Rashid RM
Dermatol Online J 2009 Jul 15;15(7):2. PMID: 19903430
Piraccini BM, Iorizzo M, Starace M, Tosti A
Dermatol Clin 2006 Jul;24(3):387-91. doi: 10.1016/j.det.2006.03.004. PMID: 16798438

Prognosis

Smith RJ, Rubin AI
Curr Opin Pediatr 2020 Aug;32(4):506-515. doi: 10.1097/MOP.0000000000000921. PMID: 32692049
Li A, Li Y, Ge L, Li P, Li W
Drug Des Devel Ther 2017;11:2373-2376. Epub 2017 Aug 14 doi: 10.2147/DDDT.S139643. PMID: 28860708Free PMC Article
Apalla Z, Sotiriou E, Pikou O, Lefaki I, Lallas A, Lazaridou E, Ioannides D
Int J Dermatol 2015 Sep;54(9):1039-44. Epub 2015 Mar 13 doi: 10.1111/ijd.12592. PMID: 25772385
Tosti A, André M, Murrell DF
Dermatol Clin 2011 Jul;29(3):511-3, xi. Epub 2011 May 6 doi: 10.1016/j.det.2011.03.006. PMID: 21605819
Serratos BD, Rashid RM
Dermatol Online J 2009 Jul 15;15(7):2. PMID: 19903430

Clinical prediction guides

Leung AKC, Lam JM, Barankin B, Leong KF, Hon KL
Recent Adv Inflamm Allergy Drug Discov 2022;16(2):77-95. doi: 10.2174/1570180820666221024095837. PMID: 36284392
Mervak JE
FP Essent 2022 Jun;517:27-34. PMID: 35679470
Arslan Uku S, Demir B, Cicek D, Inan Yuksel E
Clin Exp Dermatol 2021 Dec;46(8):1511-1517. Epub 2021 Aug 4 doi: 10.1111/ced.14783. PMID: 34089190
Akpolat ND, Karaca N
Turk J Pediatr 2016;58(3):287-290. doi: 10.24953/turkjped.2016.03.009. PMID: 28266194
Piraccini BM, Iorizzo M, Tosti A
Am J Clin Dermatol 2003;4(1):31-7. doi: 10.2165/00128071-200304010-00004. PMID: 12477371

Recent systematic reviews

Kim BR, Yu DA, Lee SR, Lim SS, Mun JH
Acta Derm Venereol 2023 Oct 30;103:adv18251. doi: 10.2340/actadv.v103.18251. PMID: 37902467Free PMC Article
Litaiem N, Drissi H, Zeglaoui F, Khachemoune A
Arch Dermatol Res 2019 Sep;311(7):505-512. Epub 2019 May 10 doi: 10.1007/s00403-019-01925-w. PMID: 31076847

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