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Wallerian degeneration

MedGen UID:
12132
Concept ID:
C0043020
Cell or Molecular Dysfunction
Synonym: Wallerian degeneration of the pyramidal tract
SNOMED CT: Wallerian degeneration (36161006); Secondary degeneration (36161006)
 
Monarch Initiative: MONDO:0043280

Definition

A condition caused by degeneration, atrophy, and destruction of the distal part of a nerve fiber''s axon and myelin, when continuity with the neural cell nucleus has been severed due to injury. Signs and symptoms include muscle weakness, altered sensation, and limb numbness. [from NCI]

Professional guidelines

PubMed

Jiang J, Wang J, Lin M, Wang X, Zhao J, Shang X
Brain Behav 2020 Oct;10(10):e01778. Epub 2020 Aug 5 doi: 10.1002/brb3.1778. PMID: 32755074Free PMC Article
Filippiadis DK, Tselikas L, Tsitskari M, Kelekis A, de Baere T, Ryan AG
Cardiovasc Intervent Radiol 2019 Jun;42(6):791-799. Epub 2019 Feb 19 doi: 10.1007/s00270-019-02185-x. PMID: 30783779
Guzmán-De-Villoria JA, Ferreiro-Argüelles C, Fernández-García P
Semin Ultrasound CT MR 2010 Jun;31(3):260-74. doi: 10.1053/j.sult.2010.03.002. PMID: 20483393

Recent clinical studies

Etiology

Contreras E, Bolívar S, Navarro X, Udina E
Exp Neurol 2022 Aug;354:114069. Epub 2022 Apr 6 doi: 10.1016/j.expneurol.2022.114069. PMID: 35398149
Kamble N, Shukla D, Bhat D
Neurol India 2019 Nov-Dec;67(6):1419-1422. doi: 10.4103/0028-3886.273626. PMID: 31857526
Decramer T, Van Keer K, Stalmans P, Dupont P, Sunaert S, Theys T
J Neurol 2018 Jan;265(1):41-45. Epub 2017 Nov 6 doi: 10.1007/s00415-017-8661-2. PMID: 29110092
Menorca RM, Fussell TS, Elfar JC
Hand Clin 2013 Aug;29(3):317-30. doi: 10.1016/j.hcl.2013.04.002. PMID: 23895713Free PMC Article
Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM
Neuron 2002 May 16;34(4):521-33. doi: 10.1016/s0896-6273(02)00682-7. PMID: 12062037

Diagnosis

Montoya-Filardi A, García-Junco Albacete M, Ortolá Fortes P, Carreres Polo J
Radiologia (Engl Ed) 2022 Mar-Apr;64(2):145-155. doi: 10.1016/j.rxeng.2022.01.001. PMID: 35504680
Kamble N, Shukla D, Bhat D
Neurol India 2019 Nov-Dec;67(6):1419-1422. doi: 10.4103/0028-3886.273626. PMID: 31857526
Llobet Rosell A, Neukomm LJ
Open Biol 2019 Aug 30;9(8):190118. Epub 2019 Aug 28 doi: 10.1098/rsob.190118. PMID: 31455157Free PMC Article
Guzmán-De-Villoria JA, Ferreiro-Argüelles C, Fernández-García P
Semin Ultrasound CT MR 2010 Jun;31(3):260-74. doi: 10.1053/j.sult.2010.03.002. PMID: 20483393
Pareyson D, Marchesi C
Lancet Neurol 2009 Jul;8(7):654-67. doi: 10.1016/S1474-4422(09)70110-3. PMID: 19539237

Therapy

Frati A, Cerretani D, Fiaschi AI, Frati P, Gatto V, La Russa R, Pesce A, Pinchi E, Santurro A, Fraschetti F, Fineschi V
Int J Mol Sci 2017 Dec 2;18(12) doi: 10.3390/ijms18122600. PMID: 29207487Free PMC Article
Thakur KK, Saini J, Mahajan K, Singh D, Jayswal DP, Mishra S, Bishayee A, Sethi G, Kunnumakkara AB
Pharmacol Res 2017 Jan;115:224-232. Epub 2016 Nov 25 doi: 10.1016/j.phrs.2016.11.019. PMID: 27894923
Sättler MB, Bähr M
Exp Neurol 2010 Sep;225(1):40-7. Epub 2009 Aug 27 doi: 10.1016/j.expneurol.2009.08.016. PMID: 19716365
Pareyson D, Marchesi C
Lancet Neurol 2009 Jul;8(7):654-67. doi: 10.1016/S1474-4422(09)70110-3. PMID: 19539237
Chaudhry V, Cornblath DR, Corse A, Freimer M, Simmons-O'Brien E, Vogelsang G
Neurology 2002 Dec 24;59(12):1872-5. doi: 10.1212/01.wnl.0000037480.59194.85. PMID: 12499476

Prognosis

Kamble N, Shukla D, Bhat D
Neurol India 2019 Nov-Dec;67(6):1419-1422. doi: 10.4103/0028-3886.273626. PMID: 31857526
Decramer T, Van Keer K, Stalmans P, Dupont P, Sunaert S, Theys T
J Neurol 2018 Jan;265(1):41-45. Epub 2017 Nov 6 doi: 10.1007/s00415-017-8661-2. PMID: 29110092
Chen YJ, Nabavizadeh SA, Vossough A, Kumar S, Loevner LA, Mohan S
J Neuroimaging 2017 May;27(3):272-280. Epub 2016 Nov 7 doi: 10.1111/jon.12404. PMID: 28072502
Pareyson D, Marchesi C
Lancet Neurol 2009 Jul;8(7):654-67. doi: 10.1016/S1474-4422(09)70110-3. PMID: 19539237
Zivadinov R, Cox JL
Int Rev Neurobiol 2007;79:449-74. doi: 10.1016/S0074-7742(07)79020-7. PMID: 17531854

Clinical prediction guides

Wang S, Song M, Yong H, Zhang C, Kang K, Liu Z, Yang Y, Huang Z, Wang S, Ge H, Zhao X, Song F
Mol Neurobiol 2022 Dec;59(12):7337-7353. Epub 2022 Sep 29 doi: 10.1007/s12035-022-03050-8. PMID: 36171479
Zheng X, Zhang Y, Man Y, Hu Z, Zhang N, Pan S
J Stroke Cerebrovasc Dis 2021 Feb;30(2):105480. Epub 2020 Nov 27 doi: 10.1016/j.jstrokecerebrovasdis.2020.105480. PMID: 33253986
Ding C, Hammarlund M
Curr Opin Neurobiol 2019 Aug;57:171-178. Epub 2019 May 6 doi: 10.1016/j.conb.2019.03.006. PMID: 31071521Free PMC Article
Singh S, Dallenga T, Winkler A, Roemer S, Maruschak B, Siebert H, Brück W, Stadelmann C
J Neuroinflammation 2017 Mar 17;14(1):57. doi: 10.1186/s12974-017-0831-8. PMID: 28302146Free PMC Article
Zivadinov R, Cox JL
Int Rev Neurobiol 2007;79:449-74. doi: 10.1016/S0074-7742(07)79020-7. PMID: 17531854

Recent systematic reviews

Maita KC, Garcia JP, Avila FR, Torres-Guzman RA, Ho O, Chini CCS, Chini EN, Forte AJ
J Surg Res 2023 Aug;288:329-340. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.017. PMID: 37060859
Lindsey HM, Hodges CB, Greer KM, Wilde EA, Merkley TL
Neuropsychol Rev 2023 Mar;33(1):42-121. Epub 2021 Mar 15 doi: 10.1007/s11065-021-09485-5. PMID: 33721207
Borger A, Stadlmayr S, Haertinger M, Semmler L, Supper P, Millesi F, Radtke C
Int J Mol Sci 2022 Mar 22;23(7) doi: 10.3390/ijms23073440. PMID: 35408800Free PMC Article
Paskal AM, Paskal W, Pietruski P, Wlodarski PK
Int J Mol Sci 2019 Mar 24;20(6) doi: 10.3390/ijms20061478. PMID: 30909624Free PMC Article
Alves GS, Oertel Knöchel V, Knöchel C, Carvalho AF, Pantel J, Engelhardt E, Laks J
Biomed Res Int 2015;2015:291658. Epub 2015 Jan 20 doi: 10.1155/2015/291658. PMID: 25685779Free PMC Article

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