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Adenocarcinoma

MedGen UID:
122
Concept ID:
C0001418
Neoplastic Process
Synonyms: Adenocarcinomas; Adenoma, Malignant; Adenomas, Malignant; Malignant Adenoma; Malignant Adenomas
SNOMED CT: Adenocarcinoma (1187332001)
 
Monarch Initiative: MONDO:0004970

Definition

A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma

Professional guidelines

PubMed

Wood LD, Canto MI, Jaffee EM, Simeone DM
Gastroenterology 2022 Aug;163(2):386-402.e1. Epub 2022 Apr 7 doi: 10.1053/j.gastro.2022.03.056. PMID: 35398344Free PMC Article
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article

Recent clinical studies

Etiology

Basolo F, Macerola E, Poma AM, Torregrossa L
Endocrine 2023 Jun;80(3):470-476. Epub 2023 Mar 25 doi: 10.1007/s12020-023-03336-4. PMID: 36964880Free PMC Article
Baraban E, Epstein J
Surg Pathol Clin 2022 Dec;15(4):579-589. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.008. PMID: 36344176
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Moore A, Donahue T
JAMA 2019 Oct 8;322(14):1426. doi: 10.1001/jama.2019.14699. PMID: 31593274Free PMC Article
Xie SH, Lagergren J
Best Pract Res Clin Gastroenterol 2018 Oct-Dec;36-37:3-8. Epub 2018 Nov 22 doi: 10.1016/j.bpg.2018.11.008. PMID: 30551854

Diagnosis

Erickson LA
Mayo Clin Proc 2021 Aug;96(8):2285-2287. doi: 10.1016/j.mayocp.2021.06.009. PMID: 34353478
Pedersen KS, Raghav K, Overman MJ
J Natl Compr Canc Netw 2019 Sep 1;17(9):1135-1141. doi: 10.6004/jnccn.2019.7344. PMID: 31487680
Hernandez-Prera JC
Head Neck Pathol 2019 Sep;13(3):415-422. Epub 2018 Sep 5 doi: 10.1007/s12105-018-0964-9. PMID: 30187348Free PMC Article
Leivo I
Head Neck Pathol 2017 Sep;11(3):295-300. Epub 2017 Mar 20 doi: 10.1007/s12105-017-0800-7. PMID: 28321774Free PMC Article
Hruban RH, Klimstra DS
Semin Diagn Pathol 2014 Nov;31(6):443-451. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.004. PMID: 25441308Free PMC Article

Therapy

Yoon HH, Jin Z, Kour O, Kankeu Fonkoua LA, Shitara K, Gibson MK, Prokop LJ, Moehler M, Kang YK, Shi Q, Ajani JA
JAMA Oncol 2022 Oct 1;8(10):1456-1465. doi: 10.1001/jamaoncol.2022.3707. PMID: 36006624Free PMC Article
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
Milano G, Innocenti F, Minami H
Cancer Sci 2022 Jul;113(7):2224-2231. Epub 2022 May 26 doi: 10.1111/cas.15377. PMID: 35445479Free PMC Article
Carpenter E, Nelson S, Bednar F, Cho C, Nathan H, Sahai V, di Magliano MP, Frankel TL
J Surg Oncol 2021 Mar;123(3):751-759. doi: 10.1002/jso.26312. PMID: 33595893
Zhang T, Park SE, Hong C, George DJ
Future Oncol 2017 Apr;13(8):755-765. Epub 2016 Nov 15 doi: 10.2217/fon-2016-0358. PMID: 27842445

Prognosis

Jakobsen E, Olsen KE, Bliddal M, Hornbak M, Persson GF, Green A
BMC Cancer 2021 Sep 3;21(1):985. doi: 10.1186/s12885-021-08696-6. PMID: 34479490Free PMC Article
Khalaf N, El-Serag HB, Abrams HR, Thrift AP
Clin Gastroenterol Hepatol 2021 May;19(5):876-884. Epub 2020 Mar 6 doi: 10.1016/j.cgh.2020.02.054. PMID: 32147593Free PMC Article
McTiernan A, Friedenreich CM, Katzmarzyk PT, Powell KE, Macko R, Buchner D, Pescatello LS, Bloodgood B, Tennant B, Vaux-Bjerke A, George SM, Troiano RP, Piercy KL; 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*
Med Sci Sports Exerc 2019 Jun;51(6):1252-1261. doi: 10.1249/MSS.0000000000001937. PMID: 31095082Free PMC Article
Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF, Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA
Neuro Oncol 2017 Oct 19;19(11):1511-1521. doi: 10.1093/neuonc/nox077. PMID: 28444227Free PMC Article
Lerner J, Goldfarb M
Ann Surg Oncol 2015 Dec;22(13):4187-92. Epub 2015 Apr 9 doi: 10.1245/s10434-015-4546-8. PMID: 25854844

Clinical prediction guides

Thota PN, Alkhayyat M, Gomez Cifuentes JD, Haider M, Bena J, McMichael J, Sohal DP, Raja S, Sanaka MR
J Clin Gastroenterol 2022 Feb 1;56(2):125-132. doi: 10.1097/MCG.0000000000001489. PMID: 33405434Free PMC Article
Hodgson A, Park KJ, Djordjevic B, Howitt BE, Nucci MR, Oliva E, Stolnicu S, Xu B, Soslow RA, Parra-Herran C
Am J Surg Pathol 2019 Jan;43(1):75-83. doi: 10.1097/PAS.0000000000001095. PMID: 29877920Free PMC Article
Gordetsky J, Epstein J
Diagn Pathol 2016 Mar 9;11:25. doi: 10.1186/s13000-016-0478-2. PMID: 26956509Free PMC Article
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179
Cohen JM, Granter SR, Werchniak AE
Clin Exp Dermatol 2015 Jul;40(5):473-8. Epub 2015 May 26 doi: 10.1111/ced.12690. PMID: 26011765

Recent systematic reviews

Asthana S, Busa V, Labani S
Eur J Obstet Gynecol Reprod Biol 2020 Apr;247:163-175. Epub 2020 Feb 21 doi: 10.1016/j.ejogrb.2020.02.014. PMID: 32114321
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article
Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, Vineis P, Forastiere F, Saldiva P, Yorifuji T, Loomis D
Environ Health Perspect 2014 Sep;122(9):906-11. Epub 2014 Jun 6 doi: 10.1289/ehp/1408092. PMID: 24911630Free PMC Article
Bailey C
BMJ Clin Evid 2011 Mar 28;2011 PMID: 21439098Free PMC Article
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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