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Adult glioblastoma

MedGen UID:: 124527
•Concept ID:: C0278878
•: Neoplastic Process

Synonyms:	Adult Glioblastoma; adult glioblastoma; adult glioblastoma multiforme; grade IV adult astrocytic neoplasm; grade IV adult astrocytic tumor; grade IV adult astrocytic tumour

Monarch Initiative:	MONDO:0020690

Definition

A glioblastoma occurring in adults. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAdult glioblastoma

Disorder of nervous system
- Disorder of the central nervous system
  - Neoplasm of the central nervous system
    - Adult Central Nervous System Neoplasm
      - Adult astrocytic tumor
        Adult infiltrating astrocytic neoplasm
        Adult glioblastoma
        Adult Brain Glioblastoma
        Adult brainstem gliosarcoma
        Adult Giant Cell Glioblastoma
        Adult Gliosarcoma
        Adult spinal cord glioblastoma

Professional guidelines

PubMed

Plasma PD-L1 as a biomarker in the clinical management of glioblastoma multiforme-a retrospective cohort study.

Masood AB, Batool S, Bhatti SN, Ali A, Valko M, Jomova K, Kuca K
Front Immunol 2023;14:1202098. Epub 2023 Jul 17 doi: 10.3389/fimmu.2023.1202098. PMID: 37529045 Free PMC Article

Glioma epigenetics: From subclassification to novel treatment options.

Gusyatiner O, Hegi ME
Semin Cancer Biol 2018 Aug;51:50-58. Epub 2017 Nov 21 doi: 10.1016/j.semcancer.2017.11.010. PMID: 29170066

Treatment outcome and prognostic factors of adult glioblastoma multiforme.

Ahmadloo N, Kani AA, Mohammadianpanah M, Nasrolahi H, Omidvari S, Mosalaei A, Ansari M
J Egypt Natl Canc Inst 2013 Mar;25(1):21-30. Epub 2012 Dec 21 doi: 10.1016/j.jnci.2012.11.001. PMID: 23499203

See all (8)

Recent clinical studies

Etiology

"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.

Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, Raleigh DR, Theodosopoulos P, Aghi MK, Chang EF, Hervey-Jumper SL, Costello JF, de Groot J, Butowski NA, Clarke JL, Chang SM, Berger MS, Molinaro AM, Solomon DA
Acta Neuropathol 2023 Dec 11;147(1):3. doi: 10.1007/s00401-023-02654-1. PMID: 38079020 Free PMC Article

Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma.

Lim-Fat MJ, Song KW, Iorgulescu JB, Andersen BM, Forst DA, Jordan JT, Gerstner ER, Reardon DA, Wen PY, Arrillaga-Romany I
J Neurooncol 2021 May;152(3):515-522. Epub 2021 Mar 1 doi: 10.1007/s11060-021-03719-5. PMID: 33646525 Free PMC Article

Molecular Profiling of Pediatric and Adult Glioblastoma.

Gestrich CK, Jajosky AN, Elliott R, Stearns D, Sadri N, Cohen ML, Couce ME
Am J Clin Pathol 2021 Mar 15;155(4):606-614. doi: 10.1093/ajcp/aqaa172. PMID: 33210143

Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.

Sturm D, Bender S, Jones DT, Lichter P, Grill J, Becher O, Hawkins C, Majewski J, Jones C, Costello JF, Iavarone A, Aldape K, Brennan CW, Jabado N, Pfister SM
Nat Rev Cancer 2014 Feb;14(2):92-107. doi: 10.1038/nrc3655. PMID: 24457416 Free PMC Article

Treatment outcome and prognostic factors of adult glioblastoma multiforme.

Ahmadloo N, Kani AA, Mohammadianpanah M, Nasrolahi H, Omidvari S, Mosalaei A, Ansari M
J Egypt Natl Canc Inst 2013 Mar;25(1):21-30. Epub 2012 Dec 21 doi: 10.1016/j.jnci.2012.11.001. PMID: 23499203

See all (59)

Diagnosis

Lessons learned from evolving frameworks in adult glioblastoma.

Lechpammer M, Mahammedi A, Pomeranz Krummel DA, Sengupta S
Handb Clin Neurol 2023;192:131-140. doi: 10.1016/B978-0-323-85538-9.00011-0. PMID: 36796938

Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement.

Bagley SJ, Kothari S, Rahman R, Lee EQ, Dunn GP, Galanis E, Chang SM, Nabors LB, Ahluwalia MS, Stupp R, Mehta MP, Reardon DA, Grossman SA, Sulman EP, Sampson JH, Khagi S, Weller M, Cloughesy TF, Wen PY, Khasraw M
Clin Cancer Res 2022 Feb 15;28(4):594-602. doi: 10.1158/1078-0432.CCR-21-2750. PMID: 34561269 Free PMC Article

Molecular Profiling of Pediatric and Adult Glioblastoma.

Gestrich CK, Jajosky AN, Elliott R, Stearns D, Sadri N, Cohen ML, Couce ME
Am J Clin Pathol 2021 Mar 15;155(4):606-614. doi: 10.1093/ajcp/aqaa172. PMID: 33210143

Adult Glioblastoma.

Alexander BM, Cloughesy TF
J Clin Oncol 2017 Jul 20;35(21):2402-2409. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.73.0119. PMID: 28640706

Treatment outcome and prognostic factors of adult glioblastoma multiforme.

Ahmadloo N, Kani AA, Mohammadianpanah M, Nasrolahi H, Omidvari S, Mosalaei A, Ansari M
J Egypt Natl Canc Inst 2013 Mar;25(1):21-30. Epub 2012 Dec 21 doi: 10.1016/j.jnci.2012.11.001. PMID: 23499203

See all (55)

Therapy

Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement.

Clinical trials using oncolytic viral therapy to treat adult glioblastoma: a progress report.

Lu VM, Shah AH, Vallejo FA, Eichberg DG, Luther EM, Shah SS, Komotar RJ, Ivan ME
Neurosurg Focus 2021 Feb;50(2):E3. doi: 10.3171/2020.11.FOCUS20860. PMID: 33524946

Tumor treating fields in pediatric high-grade glioma.

Green AL, Mulcahy Levy JM, Vibhakar R, Hemenway M, Madden J, Foreman N, Dorris K
Childs Nerv Syst 2017 Jul;33(7):1043-1045. Epub 2017 May 3 doi: 10.1007/s00381-017-3431-0. PMID: 28470383

Biomarker-based prognostic stratification of young adult glioblastoma.

Zhang RQ, Shi Z, Chen H, Chung NY, Yin Z, Li KK, Chan DT, Poon WS, Wu J, Zhou L, Chan AK, Mao Y, Ng HK
Oncotarget 2016 Jan 26;7(4):5030-41. doi: 10.18632/oncotarget.5456. PMID: 26452024 Free PMC Article

Glioblastoma survival in the United States before and during the temozolomide era.

Johnson DR, O'Neill BP
J Neurooncol 2012 Apr;107(2):359-64. Epub 2011 Nov 2 doi: 10.1007/s11060-011-0749-4. PMID: 22045118

See all (36)

Prognosis

Pediatric glioblastoma: mechanisms of immune evasion and potential therapeutic opportunities.

Njonkou R, Jackson CM, Woodworth GF, Hersh DS
Cancer Immunol Immunother 2022 Aug;71(8):1813-1822. Epub 2022 Jan 12 doi: 10.1007/s00262-021-03131-y. PMID: 35020009

Pro-inflammatory and proliferative microglia drive progression of glioblastoma.

Liu H, Sun Y, Zhang Q, Jin W, Gordon RE, Zhang Y, Wang J, Sun C, Wang ZJ, Qi X, Zhang J, Huang B, Gui Q, Yuan H, Chen L, Ma X, Fang C, Liu YQ, Yu X, Feng S
Cell Rep 2021 Sep 14;36(11):109718. doi: 10.1016/j.celrep.2021.109718. PMID: 34525361

Glioma epigenetics: From subclassification to novel treatment options.

Gusyatiner O, Hegi ME
Semin Cancer Biol 2018 Aug;51:50-58. Epub 2017 Nov 21 doi: 10.1016/j.semcancer.2017.11.010. PMID: 29170066

Adult Glioblastoma.

Alexander BM, Cloughesy TF
J Clin Oncol 2017 Jul 20;35(21):2402-2409. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.73.0119. PMID: 28640706

Metabolomic signature of brain cancer.

Pandey R, Caflisch L, Lodi A, Brenner AJ, Tiziani S
Mol Carcinog 2017 Nov;56(11):2355-2371. Epub 2017 Jul 17 doi: 10.1002/mc.22694. PMID: 28618012 Free PMC Article

See all (73)

Clinical prediction guides

"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.

Clinical features and prognostic significance of tumor involved with subventricular zone in pediatric glioblastoma: a 10-year experience in a single hospital.

Jiao Y, Wang M, Liu X, Wang J, Shou Y, Sun H
Childs Nerv Syst 2022 Aug;38(8):1469-1477. Epub 2022 Apr 26 doi: 10.1007/s00381-022-05522-7. PMID: 35474540

Glioma epigenetics: From subclassification to novel treatment options.

Gusyatiner O, Hegi ME
Semin Cancer Biol 2018 Aug;51:50-58. Epub 2017 Nov 21 doi: 10.1016/j.semcancer.2017.11.010. PMID: 29170066

Adult Glioblastoma.

Alexander BM, Cloughesy TF
J Clin Oncol 2017 Jul 20;35(21):2402-2409. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.73.0119. PMID: 28640706

Clinical and immunohistochemical prognostic factors in adult glioblastoma patients.

Umesh S, Tandon A, Santosh V, Anandh B, Sampath S, Chandramouli BA, Sastry Kolluri VR
Clin Neuropathol 2009 Sep-Oct;28(5):362-72. PMID: 19788052

See all (50)

Recent systematic reviews

A systematic review of high impact CpG sites and regions for MGMT methylation in glioblastoma [A systematic review of MGMT methylation in GBM].

Gibson D, Vo AH, Lambing H, Bhattacharya P, Tahir P, Chehab FF, Butowski N
BMC Neurol 2024 Mar 23;24(1):103. doi: 10.1186/s12883-024-03605-3. PMID: 38521933 Free PMC Article

Poor correlation between preclinical and patient efficacy data for tumor targeted monotherapies in glioblastoma: the results of a systematic review.

Gunjur A, Balasubramanian A, Hafeez U, Menon S, Cher L, Parakh S, Gan HK
J Neurooncol 2022 Sep;159(3):539-549. Epub 2022 Aug 6 doi: 10.1007/s11060-022-04092-7. PMID: 35933567

Survival analysis for valproic acid use in adult glioblastoma multiforme: a meta-analysis of individual patient data and a systematic review.

Yuan Y, Xiang W, Qing M, Yanhui L, Jiewen L, Yunhe M
Seizure 2014 Nov;23(10):830-5. Epub 2014 Jul 8 doi: 10.1016/j.seizure.2014.06.015. PMID: 25066904

See all (3)

MedGen

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Adult glioblastoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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