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Abnormal growth plate morphology

MedGen UID:
1369244
•Concept ID:
C4476734
•
Anatomical Abnormality
Synonym: Abnormality of growth plate morphology
 
HPO: HP:0025368

Definition

A structural anomaly of the growth plates (epiphyseal plates), areas of cartilage located near the ends of long bones that are located between the metaphysis (widened part of the shaft of the bone) and the epiphysis (end of the bone) and in which growth occurs in the developing bone. After conclusion of bone growth, the growth plates ossify (harden into solid bone). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal growth plate morphology

Professional guidelines

PubMed

Pediatric and adolescent anterior shoulder instability: clinical management of first-time dislocators.
Lin KM, James EW, Spitzer E, Fabricant PD
Curr Opin Pediatr 2018 Feb;30(1):49-56. doi: 10.1097/MOP.0000000000000566. PMID: 29135565
Advances in understanding etiology of achondroplasia and review of management.
Carter EM, Davis JG, Raggio CL
Curr Opin Pediatr 2007 Feb;19(1):32-7. doi: 10.1097/MOP.0b013e328013e3d9. PMID: 17224659
Proximal femoral focal deficiency: evaluation and management.
Bryant DD 3rd, Epps CH Jr
Orthopedics 1991 Jul;14(7):775-84. doi: 10.3928/0147-7447-19910701-08. PMID: 1871029

Recent clinical studies

Etiology

Growth impairment in mucopolysaccharidoses.
Melbouci M, Mason RW, Suzuki Y, Fukao T, Orii T, Tomatsu S
Mol Genet Metab 2018 May;124(1):1-10. Epub 2018 Mar 16 doi: 10.1016/j.ymgme.2018.03.004. PMID: 29627275Free PMC Article
FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.
Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, Lotz MK
Sci Transl Med 2018 Feb 14;10(428) doi: 10.1126/scitranslmed.aan0746. PMID: 29444976Free PMC Article
Filamin B: The next hotspot in skeletal research?
Xu Q, Wu N, Cui L, Wu Z, Qiu G
J Genet Genomics 2017 Jul 20;44(7):335-342. Epub 2017 Jul 6 doi: 10.1016/j.jgg.2017.04.007. PMID: 28739045
SOXC Genes and the Control of Skeletogenesis.
Lefebvre V, Bhattaram P
Curr Osteoporos Rep 2016 Feb;14(1):32-8. doi: 10.1007/s11914-016-0296-1. PMID: 26830765Free PMC Article
Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance.
Kim CJ, Romero R, Chaemsaithong P, Kim JS
Am J Obstet Gynecol 2015 Oct;213(4 Suppl):S53-69. doi: 10.1016/j.ajog.2015.08.041. PMID: 26428503Free PMC Article

Diagnosis

Ultrasonographic Diagnosis of Twin-to-Twin Transfusion Syndrome.
Reyna-Villasmil E, Briceño-Pérez C, Briceño-Sanabria JC
Am J Perinatol 2024 Apr;41(5):531-538. Epub 2022 Mar 9 doi: 10.1055/s-0042-1744259. PMID: 35263768
Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
Imaging of Pediatric Growth Plate Disturbances.
Nguyen JC, Markhardt BK, Merrow AC, Dwek JR
Radiographics 2017 Oct;37(6):1791-1812. doi: 10.1148/rg.2017170029. PMID: 29019753
Physeal bar equivalent.
Peterson HA, Shaughnessy WJ, Stans AA
J Pediatr Orthop B 2017 Nov;26(6):507-514. doi: 10.1097/BPB.0000000000000384. PMID: 27748675
Pathogenic mechanisms in osteochondrodysplasias.
Stanescu V, Stanescu R, Maroteaux P
J Bone Joint Surg Am 1984 Jul;66(6):817-36. doi: 10.2106/00004623-198466060-00002. PMID: 6376516

Therapy

Shallow Placentation: A Distinct Category of Placental Lesions.
Stanek J
Am J Perinatol 2023 Sep;40(12):1328-1335. Epub 2021 Sep 29 doi: 10.1055/s-0041-1735554. PMID: 34587634
Cellular and Molecular Alterations Underlying Abnormal Bone Growth in X-Linked Hypophosphatemia.
Fuente R, García-Bengoa M, Fernández-Iglesias Á, Gil-Peña H, Santos F, López JM
Int J Mol Sci 2022 Jan 15;23(2) doi: 10.3390/ijms23020934. PMID: 35055123Free PMC Article
Drug-induced Physeal Abnormalities in Preclinical Toxicity Studies.
Frazier KS
Toxicol Pathol 2017 Oct;45(7):869-875. Epub 2017 Jun 23 doi: 10.1177/0192623317713319. PMID: 28643552
Growth and the Growth Hormone-Insulin Like Growth Factor 1 Axis in Children With Chronic Inflammation: Current Evidence, Gaps in Knowledge, and Future Directions.
Wong SC, Dobie R, Altowati MA, Werther GA, Farquharson C, Ahmed SF
Endocr Rev 2016 Feb;37(1):62-110. Epub 2015 Dec 31 doi: 10.1210/er.2015-1026. PMID: 26720129
Recent research on the growth plate: Impact of inflammatory cytokines on longitudinal bone growth.
Sederquist B, Fernandez-Vojvodich P, Zaman F, Sävendahl L
J Mol Endocrinol 2014 Aug;53(1):T35-44. Epub 2014 Apr 7 doi: 10.1530/JME-14-0006. PMID: 24711646

Prognosis

Ultrasonographic Diagnosis of Twin-to-Twin Transfusion Syndrome.
Reyna-Villasmil E, Briceño-Pérez C, Briceño-Sanabria JC
Am J Perinatol 2024 Apr;41(5):531-538. Epub 2022 Mar 9 doi: 10.1055/s-0042-1744259. PMID: 35263768
Imaging Review of Normal and Abnormal Skeletal Maturation.
Augusto ACL, Goes PCK, Flores DV, Costa MAF, Takahashi MS, Rodrigues ACO, Padula LC, Gasparetto TD, Nogueira-Barbosa MH, Aihara AY
Radiographics 2022 May-Jun;42(3):861-879. Epub 2022 Feb 25 doi: 10.1148/rg.210088. PMID: 35213260
Abnormalities of the rib growth plate and the periphysis of previously healthy infants and toddlers dying suddenly and unexpectedly.
Groff E, Uday S, Zapata Vazquez R, Zainun K, Cohen MC
J Clin Pathol 2021 Dec;74(12):774-779. Epub 2020 Dec 8 doi: 10.1136/jclinpath-2020-206893. PMID: 33293351
Growth impairment in mucopolysaccharidoses.
Melbouci M, Mason RW, Suzuki Y, Fukao T, Orii T, Tomatsu S
Mol Genet Metab 2018 May;124(1):1-10. Epub 2018 Mar 16 doi: 10.1016/j.ymgme.2018.03.004. PMID: 29627275Free PMC Article
Pathogenic mechanisms in osteochondrodysplasias.
Stanescu V, Stanescu R, Maroteaux P
J Bone Joint Surg Am 1984 Jul;66(6):817-36. doi: 10.2106/00004623-198466060-00002. PMID: 6376516

Clinical prediction guides

Imaging Review of Normal and Abnormal Skeletal Maturation.
Augusto ACL, Goes PCK, Flores DV, Costa MAF, Takahashi MS, Rodrigues ACO, Padula LC, Gasparetto TD, Nogueira-Barbosa MH, Aihara AY
Radiographics 2022 May-Jun;42(3):861-879. Epub 2022 Feb 25 doi: 10.1148/rg.210088. PMID: 35213260
Mechanics of cortical folding: stress, growth and stability.
Garcia KE, Kroenke CD, Bayly PV
Philos Trans R Soc Lond B Biol Sci 2018 Sep 24;373(1759) doi: 10.1098/rstb.2017.0321. PMID: 30249772Free PMC Article
FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.
Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, Lotz MK
Sci Transl Med 2018 Feb 14;10(428) doi: 10.1126/scitranslmed.aan0746. PMID: 29444976Free PMC Article
Physeal bar equivalent.
Peterson HA, Shaughnessy WJ, Stans AA
J Pediatr Orthop B 2017 Nov;26(6):507-514. doi: 10.1097/BPB.0000000000000384. PMID: 27748675
Morphology and physiology of the epiphyseal growth plate.
Burdan F, Szumiło J, Korobowicz A, Farooquee R, Patel S, Patel A, Dave A, Szumiło M, Solecki M, Klepacz R, Dudka J
Folia Histochem Cytobiol 2009;47(1):5-16. doi: 10.2478/v10042-009-0007-1. PMID: 19419931

Recent systematic reviews

How does the cam morphology develop in athletes? A systematic review and meta-analysis.
Pettit M, Doran C, Singh Y, Saito M, Sunil Kumar KH, Khanduja V
Osteoarthritis Cartilage 2021 Aug;29(8):1117-1129. Epub 2021 May 11 doi: 10.1016/j.joca.2021.02.572. PMID: 33989785
What Is the Association Between Sports Participation and the Development of Proximal Femoral Cam Deformity? A Systematic Review and Meta-analysis.
Nepple JJ, Vigdorchik JM, Clohisy JC
Am J Sports Med 2015 Nov;43(11):2833-40. Epub 2015 Jan 13 doi: 10.1177/0363546514563909. PMID: 25587186

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