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Abnormal hippocampus morphology

MedGen UID:
1370323
Concept ID:
C4476590
Anatomical Abnormality
Synonyms: Abnormal morphology of the hippocampus; Abnormality of hippocampus morphology
 
HPO: HP:0025100

Definition

Any structural anomaly of the hippocampus, [from HPO]

Conditions with this feature

Mowat-Wilson syndrome
MedGen UID:
341067
Concept ID:
C1856113
Disease or Syndrome
Mowat-Wilson syndrome (MWS) is characterized by distinctive facial features (widely spaced eyes, broad eyebrows with a medial flare, low-hanging columella, prominent or pointed chin, open-mouth expression, and uplifted earlobes with a central depression), congenital heart defects with predilection for abnormalities of the pulmonary arteries and/or valves, Hirschsprung disease or chronic constipation, genitourinary anomalies (particularly hypospadias in males), and hypogenesis or agenesis of the corpus callosum. Most affected individuals have moderate-to-severe intellectual disability. Speech is typically limited to a few words or is absent, with relative preservation of receptive language skills. Growth restriction with microcephaly and seizure disorder are also common. Most affected people have a happy demeanor and a wide-based gait that can sometimes be confused with Angelman syndrome.

Professional guidelines

PubMed

Pacheco-Herrero M, Soto-Rojas LO, Reyes-Sabater H, Garcés-Ramirez L, de la Cruz López F, Villanueva-Fierro I, Luna-Muñoz J
J Alzheimers Dis 2021;84(3):917-935. doi: 10.3233/JAD-200863. PMID: 34633316Free PMC Article
Duman CH, Duman RS
Neurosci Lett 2015 Aug 5;601:20-9. Epub 2015 Jan 9 doi: 10.1016/j.neulet.2015.01.022. PMID: 25582786Free PMC Article
Tüzün E, Dalmau J
Neurologist 2007 Sep;13(5):261-71. doi: 10.1097/NRL.0b013e31813e34a5. PMID: 17848866

Recent clinical studies

Etiology

Wegrzyn D, Juckel G, Faissner A
Int J Mol Sci 2022 May 13;23(10) doi: 10.3390/ijms23105482. PMID: 35628292Free PMC Article
Sämann PG, Iglesias JE, Gutman B, Grotegerd D, Leenings R, Flint C, Dannlowski U, Clarke-Rubright EK, Morey RA, van Erp TGM, Whelan CD, Han LKM, van Velzen LS, Cao B, Augustinack JC, Thompson PM, Jahanshad N, Schmaal L
Hum Brain Mapp 2022 Jan;43(1):207-233. Epub 2020 Dec 27 doi: 10.1002/hbm.25326. PMID: 33368865Free PMC Article
Santos VR, Melo IS, Pacheco ALD, Castro OW
Epilepsy Behav 2021 Aug;121(Pt B):106595. Epub 2019 Nov 20 doi: 10.1016/j.yebeh.2019.106595. PMID: 31759972
Rocca MA, Barkhof F, De Luca J, Frisén J, Geurts JJG, Hulst HE, Sastre-Garriga J, Filippi M; MAGNIMS Study Group
Lancet Neurol 2018 Oct;17(10):918-926. Epub 2018 Sep 18 doi: 10.1016/S1474-4422(18)30309-0. PMID: 30264730
Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfäfflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rössler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Özkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Mühlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G; EEBB Consortium
N Engl J Med 2017 Oct 26;377(17):1648-1656. doi: 10.1056/NEJMoa1703784. PMID: 29069555

Diagnosis

Sämann PG, Iglesias JE, Gutman B, Grotegerd D, Leenings R, Flint C, Dannlowski U, Clarke-Rubright EK, Morey RA, van Erp TGM, Whelan CD, Han LKM, van Velzen LS, Cao B, Augustinack JC, Thompson PM, Jahanshad N, Schmaal L
Hum Brain Mapp 2022 Jan;43(1):207-233. Epub 2020 Dec 27 doi: 10.1002/hbm.25326. PMID: 33368865Free PMC Article
Santos VR, Melo IS, Pacheco ALD, Castro OW
Epilepsy Behav 2021 Aug;121(Pt B):106595. Epub 2019 Nov 20 doi: 10.1016/j.yebeh.2019.106595. PMID: 31759972
Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfäfflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rössler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Özkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Mühlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G; EEBB Consortium
N Engl J Med 2017 Oct 26;377(17):1648-1656. doi: 10.1056/NEJMoa1703784. PMID: 29069555
Isnard J, Bourdillon P
Rev Neurol (Paris) 2015 Mar;171(3):298-306. Epub 2015 Mar 2 doi: 10.1016/j.neurol.2014.12.002. PMID: 25744767
Szabo K, Förster A, Gass A
Front Neurol Neurosci 2014;34:71-84. Epub 2014 Apr 16 doi: 10.1159/000357925. PMID: 24777132

Therapy

Pinto B, Morelli G, Rastogi M, Savardi A, Fumagalli A, Petretto A, Bartolucci M, Varea E, Catelani T, Contestabile A, Perlini LE, Cancedda L
Neuron 2020 Dec 9;108(5):887-904.e12. Epub 2020 Oct 6 doi: 10.1016/j.neuron.2020.09.010. PMID: 33027640Free PMC Article
Georgieff MK
Am J Obstet Gynecol 2020 Oct;223(4):516-524. Epub 2020 Mar 14 doi: 10.1016/j.ajog.2020.03.006. PMID: 32184147Free PMC Article
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Hum Mol Genet 2018 Jul 15;27(14):2502-2516. doi: 10.1093/hmg/ddy154. PMID: 29701781Free PMC Article
Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI
Gen Hosp Psychiatry 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. PMID: 29122145Free PMC Article
Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF
Nat Rev Dis Primers 2016 Sep 15;2:16065. doi: 10.1038/nrdp.2016.65. PMID: 27629598

Prognosis

Isnard J, Bourdillon P
Rev Neurol (Paris) 2015 Mar;171(3):298-306. Epub 2015 Mar 2 doi: 10.1016/j.neurol.2014.12.002. PMID: 25744767
Mak AD, Lam LC
Curr Opin Psychiatry 2013 Jan;26(1):90-6. doi: 10.1097/YCO.0b013e32835b57a9. PMID: 23196999
Brambilla P, Hatch JP, Soares JC
Curr Psychiatry Rep 2008 Dec;10(6):505-9. doi: 10.1007/s11920-008-0080-8. PMID: 18980734
Valenstein E, Bowers D, Verfaellie M, Heilman KM, Day A, Watson RT
Brain 1987 Dec;110 ( Pt 6):1631-46. doi: 10.1093/brain/110.6.1631. PMID: 3427404
Price DL
Annu Rev Neurosci 1986;9:489-512. doi: 10.1146/annurev.ne.09.030186.002421. PMID: 3518588

Clinical prediction guides

Wegrzyn D, Juckel G, Faissner A
Int J Mol Sci 2022 May 13;23(10) doi: 10.3390/ijms23105482. PMID: 35628292Free PMC Article
Caciagli L, Wandschneider B, Xiao F, Vollmar C, Centeno M, Vos SB, Trimmel K, Sidhu MK, Thompson PJ, Winston GP, Duncan JS, Koepp MJ
Brain 2019 Sep 1;142(9):2670-2687. doi: 10.1093/brain/awz215. PMID: 31365054Free PMC Article
Kalmady SV, Shivakumar V, Arasappa R, Subramaniam A, Gautham S, Venkatasubramanian G, Gangadhar BN
Psychiatry Res Neuroimaging 2017 May 30;263:93-102. Epub 2017 Mar 29 doi: 10.1016/j.pscychresns.2017.03.014. PMID: 28371658
Takeda A
Mol Neurobiol 2011 Oct;44(2):166-74. Epub 2010 Dec 15 doi: 10.1007/s12035-010-8158-9. PMID: 21161611
Marcorelles P, Laquerriere A
Am J Med Genet C Semin Med Genet 2010 Feb 15;154C(1):109-19. doi: 10.1002/ajmg.c.30249. PMID: 20104606

Recent systematic reviews

Haukvik UK, Tamnes CK, Söderman E, Agartz I
J Psychiatr Res 2018 Sep;104:217-226. Epub 2018 Aug 7 doi: 10.1016/j.jpsychires.2018.08.012. PMID: 30107268
Milani AC, Hoffmann EV, Fossaluza V, Jackowski AP, Mello MF
Psychiatry Clin Neurosci 2017 Mar;71(3):154-169. Epub 2017 Jan 6 doi: 10.1111/pcn.12473. PMID: 27778421
Xavier RM, Vorderstrasse A
Nurs Res 2016 May-Jun;65(3):224-37. doi: 10.1097/NNR.0000000000000159. PMID: 27124258
Roda Â, Chendo I, Kunz M
Trends Psychiatry Psychother 2015 Jan-Mar;37(1):3-11. Epub 2014 Dec 9 doi: 10.1590/2237-6089-2014-0002. PMID: 25860561
Fraser MA, Shaw ME, Cherbuin N
Neuroimage 2015 May 15;112:364-374. Epub 2015 Mar 20 doi: 10.1016/j.neuroimage.2015.03.035. PMID: 25800208

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