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Yellow papule

MedGen UID:
1373750
Concept ID:
C2033396
Finding
Synonym: Yellow-orange papule
 
HPO: HP:0025507

Definition

A papule with yellow color. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVYellow papule

Conditions with this feature

Autosomal recessive inherited pseudoxanthoma elasticum
MedGen UID:
698415
Concept ID:
C1275116
Disease or Syndrome
Pseudoxanthoma elasticum (PXE) is a systemic disorder that affects the elastic tissue of the skin, the eye, and vascular system. Individuals most commonly present with angioid streaks of the retina found on routine eye examination or associated with retinal hemorrhage and/or characteristic papules in the skin. The most frequent cause of morbidity and disability in PXE is reduced vision due to complications of subretinal neovascularizations and macular atrophy. Other manifestations include premature gastrointestinal angina and/or bleeding, intermittent claudication of arm and leg muscles, stroke, renovascular hypertension, and cardiovascular complications (angina/myocardial infarction). Most affected individuals live a normal life span.
Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency
MedGen UID:
332067
Concept ID:
C1835813
Disease or Syndrome
Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency is a very rare genetic skin disease characterized by severe skin laxity affecting the trunk and limbs.
Sebaceous gland hyperplasia, familial presenile
MedGen UID:
356529
Concept ID:
C1866428
Disease or Syndrome
Sebaceous gland hyperplasia presents as one or more elevated, soft, yellow papules with central umbilication on the face, particularly the forehead. Lesions may spread to the neck and upper part of the thorax. Sebaceous gland hyperplasia occurs frequently in older individuals, particularly in men past middle age (Nomland, 1930). A premature form has its appearance during puberty or just afterwards, male predominance, and excessive sebaceous secretion. Most cases are sporadic (summary by Boonchai and Leenutaphong, 1997).
Pseudoxanthoma elasticum, forme fruste
MedGen UID:
357280
Concept ID:
C1867450
Disease or Syndrome
Pseudoxanthoma elasticum (PXE) is a systemic disorder that affects the elastic tissue of the skin, the eye, and vascular system. Individuals most commonly present with angioid streaks of the retina found on routine eye examination or associated with retinal hemorrhage and/or characteristic papules in the skin. The most frequent cause of morbidity and disability in PXE is reduced vision due to complications of subretinal neovascularizations and macular atrophy. Other manifestations include premature gastrointestinal angina and/or bleeding, intermittent claudication of arm and leg muscles, stroke, renovascular hypertension, and cardiovascular complications (angina/myocardial infarction). Most affected individuals live a normal life span.

Professional guidelines

PubMed

Temiz SA, Ataseven A, Dursun R
J Cosmet Dermatol 2022 Sep;21(9):3814-3816. Epub 2022 May 31 doi: 10.1111/jocd.15088. PMID: 35569135
Edwards S, Boffa MJ, Janier M, Calzavara-Pinton P, Rovati C, Salavastru CM, Rongioletti F, Wollenberg A, Butacu AI, Skerlev M, Tiplica GS
J Eur Acad Dermatol Venereol 2021 Jan;35(1):17-26. Epub 2020 Sep 2 doi: 10.1111/jdv.16856. PMID: 32881110
Leung AKC, Lam JM, Leong KF
Curr Pediatr Rev 2019;15(1):42-46. doi: 10.2174/1573396315666181120163952. PMID: 30465511Free PMC Article

Recent clinical studies

Etiology

Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209

Diagnosis

Rocha AC, Sá MI, Abrantes C, Sousa R
Acta Med Port 2022 Jan 3;35(1):63-67. doi: 10.20344/amp.13551. PMID: 35225764
See SHC, Tan TL, Kurtzer TA, Gerami P, Guitart J, Yazdan P
Am J Dermatopathol 2021 Jun 1;43(6):418-422. doi: 10.1097/DAD.0000000000001862. PMID: 33298708
Oliveira TE, Tarlé RG, Mesquita LAF
An Bras Dermatol 2018 Jan-Feb;93(1):138-140. doi: 10.1590/abd1806-4841.20186849. PMID: 29641718Free PMC Article
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Lourenço SV, Teshima TH, Nagano CP, Fernandes JD, Nico MM
J Dtsch Dermatol Ges 2014 Jun;12(6):514-5. doi: 10.1111/ddg.12282. PMID: 24889302

Prognosis

Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209

Clinical prediction guides

See SHC, Tan TL, Kurtzer TA, Gerami P, Guitart J, Yazdan P
Am J Dermatopathol 2021 Jun 1;43(6):418-422. doi: 10.1097/DAD.0000000000001862. PMID: 33298708

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