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B Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21

MedGen UID:
1374530
Concept ID:
C4329380
Neoplastic Process
Synonyms: B Acute Lymphoblastic Leukemia with iAMP21; B-ALL with iAMP21

Definition

B acute lymphoblastic leukemia characterized by amplification of a portion of chromosome 21. It usually occurs in children and is associated with an adverse prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21

Professional guidelines

PubMed

Moorman AV, Robinson H, Schwab C, Richards SM, Hancock J, Mitchell CD, Goulden N, Vora A, Harrison CJ
J Clin Oncol 2013 Sep 20;31(27):3389-96. Epub 2013 Aug 12 doi: 10.1200/JCO.2013.48.9377. PMID: 23940220

Recent clinical studies

Etiology

Gao Q, Ryan SL, Iacobucci I, Ghate PS, Cranston RE, Schwab C, Elsayed AH, Shi L, Pounds S, Lei S, Baviskar P, Pei D, Cheng C, Bashton M, Sinclair P, Bentley DR, Ross MT, Kingsbury Z, James T, Roberts KG, Devidas M, Fan Y, Chen W, Chang TC, Wu G, Carroll A, Heerema N, Valentine V, Valentine M, Yang W, Yang JJ, Moorman AV, Harrison CJ, Mullighan CG
Blood 2023 Aug 24;142(8):711-723. doi: 10.1182/blood.2022019094. PMID: 37216686Free PMC Article
Baloda V, Aggarwal N, Rosado FG, Mackey S, Felker J, Yatsenko SA
Cytogenet Genome Res 2022;162(5):231-236. Epub 2022 Dec 9 doi: 10.1159/000527025. PMID: 36502796
Zak T, Gao J, Behdad A, Mehta J, Altman JK, Ji P, Lu X, Sukhanova M
Leuk Lymphoma 2022 Dec;63(13):3200-3207. Epub 2022 Aug 22 doi: 10.1080/10428194.2022.2113524. PMID: 35995457
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Harrison CJ
Hematology Am Soc Hematol Educ Program 2013;2013:118-25. doi: 10.1182/asheducation-2013.1.118. PMID: 24319172

Diagnosis

Gao Q, Ryan SL, Iacobucci I, Ghate PS, Cranston RE, Schwab C, Elsayed AH, Shi L, Pounds S, Lei S, Baviskar P, Pei D, Cheng C, Bashton M, Sinclair P, Bentley DR, Ross MT, Kingsbury Z, James T, Roberts KG, Devidas M, Fan Y, Chen W, Chang TC, Wu G, Carroll A, Heerema N, Valentine V, Valentine M, Yang W, Yang JJ, Moorman AV, Harrison CJ, Mullighan CG
Blood 2023 Aug 24;142(8):711-723. doi: 10.1182/blood.2022019094. PMID: 37216686Free PMC Article
Baloda V, Aggarwal N, Rosado FG, Mackey S, Felker J, Yatsenko SA
Cytogenet Genome Res 2022;162(5):231-236. Epub 2022 Dec 9 doi: 10.1159/000527025. PMID: 36502796
Zak T, Gao J, Behdad A, Mehta J, Altman JK, Ji P, Lu X, Sukhanova M
Leuk Lymphoma 2022 Dec;63(13):3200-3207. Epub 2022 Aug 22 doi: 10.1080/10428194.2022.2113524. PMID: 35995457
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Baughn LB, Meredith MM, Oseth L, Smolarek TA, Hirsch B
Cancer Genet 2018 Oct;226-227:30-35. Epub 2018 Jun 8 doi: 10.1016/j.cancergen.2018.05.004. PMID: 30005852

Therapy

Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Heerema NA, Carroll AJ, Devidas M, Loh ML, Borowitz MJ, Gastier-Foster JM, Larsen EC, Mattano LA Jr, Maloney KW, Willman CL, Wood BL, Winick NJ, Carroll WL, Hunger SP, Raetz EA
J Clin Oncol 2013 Sep 20;31(27):3397-402. Epub 2013 Aug 12 doi: 10.1200/JCO.2013.49.1308. PMID: 23940221Free PMC Article
Moorman AV, Robinson H, Schwab C, Richards SM, Hancock J, Mitchell CD, Goulden N, Vora A, Harrison CJ
J Clin Oncol 2013 Sep 20;31(27):3389-96. Epub 2013 Aug 12 doi: 10.1200/JCO.2013.48.9377. PMID: 23940220
Attarbaschi A, Mann G, Panzer-Grümayer R, Röttgers S, Steiner M, König M, Csinady E, Dworzak MN, Seidel M, Janousek D, Möricke A, Reichelt C, Harbott J, Schrappe M, Gadner H, Haas OA
J Clin Oncol 2008 Jun 20;26(18):3046-50. doi: 10.1200/JCO.2008.16.1117. PMID: 18565891
Moorman AV, Richards SM, Robinson HM, Strefford JC, Gibson BE, Kinsey SE, Eden TO, Vora AJ, Mitchell CD, Harrison CJ; UK Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Childhood Leukaemia Working Party (CLWP)
Blood 2007 Mar 15;109(6):2327-30. Epub 2006 Nov 9 doi: 10.1182/blood-2006-08-040436. PMID: 17095619

Prognosis

Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG
Nat Genet 2022 Sep;54(9):1376-1389. Epub 2022 Sep 1 doi: 10.1038/s41588-022-01159-z. PMID: 36050548Free PMC Article
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Tsuchiya KD, Davis B, Gardner RA
Cancer Genet 2017 Dec;218-219:10-14. Epub 2017 Aug 31 doi: 10.1016/j.cancergen.2017.08.005. PMID: 29153092
Harrison CJ
Hematology Am Soc Hematol Educ Program 2013;2013:118-25. doi: 10.1182/asheducation-2013.1.118. PMID: 24319172
Harrison CJ
Br J Haematol 2009 Jan;144(2):147-56. Epub 2008 Nov 1 doi: 10.1111/j.1365-2141.2008.07417.x. PMID: 19006567

Clinical prediction guides

Baloda V, Aggarwal N, Rosado FG, Mackey S, Felker J, Yatsenko SA
Cytogenet Genome Res 2022;162(5):231-236. Epub 2022 Dec 9 doi: 10.1159/000527025. PMID: 36502796
Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343Free PMC Article
Sinclair PB, Blair HH, Ryan SL, Buechler L, Cheng J, Clayton J, Hanna R, Hollern S, Hawking Z, Bashton M, Schwab CJ, Jones L, Russell LJ, Marr H, Carey P, Halsey C, Heidenreich O, Moorman AV, Harrison CJ
Haematologica 2018 Apr;103(4):634-644. Epub 2018 Feb 15 doi: 10.3324/haematol.2017.172304. PMID: 29449437Free PMC Article
Wang Y, Miller S, Roulston D, Bixby D, Shao L
J Mol Diagn 2016 Jul;18(4):595-603. Epub 2016 May 6 doi: 10.1016/j.jmoldx.2016.03.004. PMID: 27161658
Attarbaschi A, Mann G, Panzer-Grümayer R, Röttgers S, Steiner M, König M, Csinady E, Dworzak MN, Seidel M, Janousek D, Möricke A, Reichelt C, Harbott J, Schrappe M, Gadner H, Haas OA
J Clin Oncol 2008 Jun 20;26(18):3046-50. doi: 10.1200/JCO.2008.16.1117. PMID: 18565891

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