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Keratinizing squamous cell carcinoma

MedGen UID:
137730
•Concept ID:
C0334247
•
Neoplastic Process
Synonyms: Epidermoid carcinoma, keratinizing; Keratinizing epidermoid carcinoma; keratinizing epidermoid carcinoma; Keratinizing Squamous Cell Carcinoma; keratinizing squamous cell carcinoma; Keratinizing squamous cell carcinoma - large cell; Squamous cell carcinoma, keratinizing; squamous cell carcinoma, keratinizing; squamous cell carcinoma, keratinizing (morphologic abnormality); Squamous cell carcinoma, large cell, keratinizing
SNOMED CT: Keratinizing squamous cell carcinoma - large cell (18048008); Keratinizing epidermoid carcinoma (18048008); Squamous cell carcinoma, keratinizing (18048008); Squamous cell carcinoma, large cell, keratinizing (18048008); Epidermoid carcinoma, keratinizing (18048008)
 
Monarch Initiative: MONDO:0005056

Definition

Squamous cell carcinomas with morphologically prominent production of keratin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKeratinizing squamous cell carcinoma

Professional guidelines

PubMed

Comparison of Epstein-Barr virus genotypes and clinicohistopathological features of nasopharyngeal carcinoma between Guilin, China and Fukuoka, Japan.
Zhou Y, Nabeshima K, Koga K, Aoki M, Hayashi H, Hamasaki M, Iwasaki H
Oncol Rep 2008 Jun;19(6):1413-20. PMID: 18497945
Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases.
Alos L, Castillo M, Nadal A, Caballero M, Mallofre C, Palacin A, Cardesa A
Histopathology 2004 Jun;44(6):570-9. doi: 10.1111/j.1365-2559.2004.01881.x. PMID: 15186272

Recent clinical studies

Etiology

HPV-Associated Squamous Cell Carcinoma of the Eyelid: Diagnostic Utility of p16 Immunohistochemistry and mRNA In Situ Hybridization.
Kakkar A, Srivastava K, Deepa S, Kashyap S, Sen S, Bhoriwal S, Kaur K, Deo SVS
Head Neck Pathol 2023 Dec;17(4):889-898. Epub 2023 Sep 21 doi: 10.1007/s12105-023-01582-6. PMID: 37735287Free PMC Article
Correlation of clinicopathologic features and lung squamous cell carcinoma subtypes according to the 2015 WHO classification.
Chen R, Ding Z, Zhu L, Lu S, Yu Y
Eur J Surg Oncol 2017 Dec;43(12):2308-2314. Epub 2017 Sep 19 doi: 10.1016/j.ejso.2017.09.011. PMID: 28964610
Infectious Agents Associated with Head and Neck Carcinomas.
Hettmann A, Demcsák A, Decsi G, Bach Á, Pálinkó D, Rovó L, Nagy K, Takács M, Minarovits J
Adv Exp Med Biol 2016;897:63-80. doi: 10.1007/5584_2015_5005. PMID: 26563307
Laryngeal Papillary Squamous Cell Carcinoma: A Population-Based Analysis of Incidence and Survival.
Dutta R, Husain Q, Kam D, Dubal PM, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2015 Jul;153(1):54-9. Epub 2015 Apr 27 doi: 10.1177/0194599815581613. PMID: 25917664
HPV-related squamous cell carcinoma of the head and neck: An update on testing in routine pathology practice.
Bishop JA, Lewis JS Jr, Rocco JW, Faquin WC
Semin Diagn Pathol 2015 Sep;32(5):344-51. Epub 2015 Feb 4 doi: 10.1053/j.semdp.2015.02.013. PMID: 25724476

Diagnosis

Comparing Genomic Landscapes of Oral and Cutaneous Squamous Cell Carcinoma of the Head and Neck: Quest for Novel Diagnostic Markers.
Gupta R, Strbenac D, Satgunaseelan L, Cheung VK, Narayanappa H, Ashford B, Mitchell J, Thind A, Palme CE, Ch'ng S, Low TH, Wykes J, Willet CE, Chew T, Yang J, Ranson M, Clark JR
Mod Pathol 2023 Aug;36(8):100190. Epub 2023 Apr 18 doi: 10.1016/j.modpat.2023.100190. PMID: 37080394
Wolf in sheep's clothing - Oral proliferative verrucous leukoplakia: Progression with longitudinal molecular insights.
Afkhami M, Maghami E, Gernon TJ, Villaflor V, Bell D
Ann Diagn Pathol 2023 Apr;63:152104. Epub 2023 Jan 6 doi: 10.1016/j.anndiagpath.2023.152104. PMID: 36640643
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
HPV-related squamous cell carcinoma of the head and neck: An update on testing in routine pathology practice.
Bishop JA, Lewis JS Jr, Rocco JW, Faquin WC
Semin Diagn Pathol 2015 Sep;32(5):344-51. Epub 2015 Feb 4 doi: 10.1053/j.semdp.2015.02.013. PMID: 25724476

Therapy

Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database.
Yu H, Xie S, Zheng X, Zhao Q, Xia X, Ming WK, Cheng LN, Duan X, Huang WE, Huang F, Lyu J, Deng L
Int J Clin Pract 2023;2023:3016994. Epub 2023 Feb 24 doi: 10.1155/2023/3016994. PMID: 36874384Free PMC Article
A Novel Prognostic Risk Model for Cervical Cancer Based on Immune Checkpoint HLA-G-Driven Differentially Expressed Genes.
Xu HH, Wang HL, Xing TJ, Wang XQ
Front Immunol 2022;13:851622. Epub 2022 Jul 18 doi: 10.3389/fimmu.2022.851622. PMID: 35924232Free PMC Article
Re-irradiation with Moderate Hypo-fractionation Using Intensity Modulated Photon or Proton Radiation Therapy in Locally Recurrent Squamous Cell Carcinoma of Nasopharynx.
Nam H, Ahn YC, Yang K, Oh D, Noh JM
Cancer Res Treat 2022 Jan;54(1):96-108. Epub 2021 Mar 26 doi: 10.4143/crt.2020.1349. PMID: 33781049Free PMC Article
Malignant pleural neoplasm with both differentiation of epithelioid mesothelioma and squamous-cell carcinoma, a rare phenomena.
Re A, Shersher D, Allen A, Schwarting R, Ren S
Diagn Cytopathol 2021 Jun;49(6):E234-E237. Epub 2020 Dec 21 doi: 10.1002/dc.24686. PMID: 33347735
The significance of keratinizing squamous cell histology in Chinese patients with nasopharyngeal carcinoma.
Chan AT, Teo ML, Lee WY, Kwan WH, Choi PH, Johnson PJ
Clin Oncol (R Coll Radiol) 1998;10(3):161-4. doi: 10.1016/s0936-6555(98)80057-5. PMID: 9704177

Prognosis

Comparing Genomic Landscapes of Oral and Cutaneous Squamous Cell Carcinoma of the Head and Neck: Quest for Novel Diagnostic Markers.
Gupta R, Strbenac D, Satgunaseelan L, Cheung VK, Narayanappa H, Ashford B, Mitchell J, Thind A, Palme CE, Ch'ng S, Low TH, Wykes J, Willet CE, Chew T, Yang J, Ranson M, Clark JR
Mod Pathol 2023 Aug;36(8):100190. Epub 2023 Apr 18 doi: 10.1016/j.modpat.2023.100190. PMID: 37080394
Wolf in sheep's clothing - Oral proliferative verrucous leukoplakia: Progression with longitudinal molecular insights.
Afkhami M, Maghami E, Gernon TJ, Villaflor V, Bell D
Ann Diagn Pathol 2023 Apr;63:152104. Epub 2023 Jan 6 doi: 10.1016/j.anndiagpath.2023.152104. PMID: 36640643
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
HPV-related squamous cell carcinoma of the head and neck: An update on testing in routine pathology practice.
Bishop JA, Lewis JS Jr, Rocco JW, Faquin WC
Semin Diagn Pathol 2015 Sep;32(5):344-51. Epub 2015 Feb 4 doi: 10.1053/j.semdp.2015.02.013. PMID: 25724476

Clinical prediction guides

Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database.
Yu H, Xie S, Zheng X, Zhao Q, Xia X, Ming WK, Cheng LN, Duan X, Huang WE, Huang F, Lyu J, Deng L
Int J Clin Pract 2023;2023:3016994. Epub 2023 Feb 24 doi: 10.1155/2023/3016994. PMID: 36874384Free PMC Article
MTA1 as negative prognostic marker in vulvar carcinoma.
Wanka G, Jueckstock J, Wild CM, Vattai A, Fürst S, Heidegger HH, Kuhn C, Schmoeckel E, Jeschke U, Dannecker C
J Cancer Res Clin Oncol 2023 Aug;149(9):6191-6201. Epub 2023 Jan 23 doi: 10.1007/s00432-023-04579-4. PMID: 36689059Free PMC Article
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
HPV-related squamous cell carcinoma of the head and neck: An update on testing in routine pathology practice.
Bishop JA, Lewis JS Jr, Rocco JW, Faquin WC
Semin Diagn Pathol 2015 Sep;32(5):344-51. Epub 2015 Feb 4 doi: 10.1053/j.semdp.2015.02.013. PMID: 25724476

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