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Undifferentiated Retinoblastoma

MedGen UID:
137788
•Concept ID:
C0334601
•
Neoplastic Process
Synonyms: Retinoblastoma - undifferentiated; Retinoblastoma, undifferentiated
SNOMED CT: Retinoblastoma - undifferentiated (12354007); Retinoblastoma, undifferentiated (12354007)

Definition

A retinoblastoma composed of small, undifferentiated cells. It is often associated with necrotic changes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated Retinoblastoma

Professional guidelines

PubMed

Craniofacial second primary tumors in patients with germline retinoblastoma previously treated with external beam radiotherapy: A retrospective institutional analysis.
Jiménez I, Laé M, Tanguy ML, Savignoni A, Gauthier-Villars M, Desjardins L, Cassoux N, Dendale R, Rodriguez J, Doz F, Brisse HJ, Aerts I
Pediatr Blood Cancer 2020 Apr;67(4):e28158. Epub 2020 Jan 6 doi: 10.1002/pbc.28158. PMID: 31904159
Immunohistochemical evaluation of p53 and retinoblastoma proteins in relation to hyperthermia treatment: results in human urothelial carcinomas.
Okamura T, Ueda K, Hashimoto Y, Tozawa K, Kohri K
Int J Hyperthermia 1996 Nov-Dec;12(6):813-24. doi: 10.3109/02656739609027687. PMID: 8950161
Iridium afterloading curietherapy in the treatment of pediatric malignancies. The Institut Gustave Roussy experience.
Gerbaulet A, Panis X, Flamant F, Chassagne D
Cancer 1985 Sep 15;56(6):1274-9. doi: 10.1002/1097-0142(19850915)56:6<1274::aid-cncr2820560609>3.0.co;2-8. PMID: 4027867

Recent clinical studies

Etiology

Role of apparent diffusion map in the evaluation of retinoblastoma.
Spadoni VS, Conceição TMBD, Schaefer FDC, Ercolani DS, Maestri MK, Klaes A, Selistre SG, Reis F, Duarte JÁ
Arq Bras Oftalmol 2024;87(2):e20210435. Epub 2024 Feb 23 doi: 10.5935/0004-2749.2021-0435. PMID: 38422355
Photoreceptor cell differentiation in retinoblastoma demonstrated by a new immunohistochemical marker mucin-like glycoprotein associated with photoreceptor cells (MLGAPC).
Tsuji M, Goto M, Uehara F, Kaneko A, Sawai J, Yonezawa S, Ohba N
Histopathology 2002 Feb;40(2):180-6. doi: 10.1046/j.1365-2559.2002.01320.x. PMID: 11952864
Malignant transformation of spontaneously regressed retinoblastoma, retinoma/retinocytoma variant.
Eagle RC Jr, Shields JA, Donoso L, Milner RS
Ophthalmology 1989 Sep;96(9):1389-95. doi: 10.1016/s0161-6420(89)32714-x. PMID: 2780006
Scanning electron microscopy of retinoblastoma.
Radnot M
J Pediatr Ophthalmol Strabismus 1978 Jan-Feb;15(1):36-9. doi: 10.3928/0191-3913-19780101-12. PMID: 216787

Diagnosis

Role of apparent diffusion map in the evaluation of retinoblastoma.
Spadoni VS, Conceição TMBD, Schaefer FDC, Ercolani DS, Maestri MK, Klaes A, Selistre SG, Reis F, Duarte JÁ
Arq Bras Oftalmol 2024;87(2):e20210435. Epub 2024 Feb 23 doi: 10.5935/0004-2749.2021-0435. PMID: 38422355
Correlation of apparent diffusion coefficient at 3T with prognostic parameters of retinoblastoma.
Abdel Razek AA, Elkhamary S, Al-Mesfer S, Alkatan HM
AJNR Am J Neuroradiol 2012 May;33(5):944-8. Epub 2012 Jan 12 doi: 10.3174/ajnr.A2892. PMID: 22241394Free PMC Article
Malignant transformation of spontaneously regressed retinoblastoma, retinoma/retinocytoma variant.
Eagle RC Jr, Shields JA, Donoso L, Milner RS
Ophthalmology 1989 Sep;96(9):1389-95. doi: 10.1016/s0161-6420(89)32714-x. PMID: 2780006
Magnetic resonance imaging in retinoblastoma and retinocytoma: a case report.
Benhamou E, Borges J, Tso MO
J Pediatr Ophthalmol Strabismus 1989 Nov-Dec;26(6):276-80. doi: 10.3928/0191-3913-19891101-06. PMID: 2621546

Therapy

Calcium mobilization by activation of M(3)/M(5) muscarinic receptors in the human retinoblastoma.
Kim DR, Rah SH, Sohn JH, Yeh BI, Ko CM, Park JS, Kim MJ, Lee JW, Kong ID
J Pharmacol Sci 2007 Oct;105(2):184-92. doi: 10.1254/jphs.fp0070877. PMID: 17951979

Prognosis

Role of apparent diffusion map in the evaluation of retinoblastoma.
Spadoni VS, Conceição TMBD, Schaefer FDC, Ercolani DS, Maestri MK, Klaes A, Selistre SG, Reis F, Duarte JÁ
Arq Bras Oftalmol 2024;87(2):e20210435. Epub 2024 Feb 23 doi: 10.5935/0004-2749.2021-0435. PMID: 38422355
Correlation of apparent diffusion coefficient at 3T with prognostic parameters of retinoblastoma.
Abdel Razek AA, Elkhamary S, Al-Mesfer S, Alkatan HM
AJNR Am J Neuroradiol 2012 May;33(5):944-8. Epub 2012 Jan 12 doi: 10.3174/ajnr.A2892. PMID: 22241394Free PMC Article
Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells.
Bertolesi GE, Walia Da Silva R, Jollimore CA, Shi C, Barnes S, Kelly ME
Neuroscience 2006 Aug 11;141(1):259-68. Epub 2006 May 6 doi: 10.1016/j.neuroscience.2006.03.067. PMID: 16678971
Malignant transformation of spontaneously regressed retinoblastoma, retinoma/retinocytoma variant.
Eagle RC Jr, Shields JA, Donoso L, Milner RS
Ophthalmology 1989 Sep;96(9):1389-95. doi: 10.1016/s0161-6420(89)32714-x. PMID: 2780006

Clinical prediction guides

Role of apparent diffusion map in the evaluation of retinoblastoma.
Spadoni VS, Conceição TMBD, Schaefer FDC, Ercolani DS, Maestri MK, Klaes A, Selistre SG, Reis F, Duarte JÁ
Arq Bras Oftalmol 2024;87(2):e20210435. Epub 2024 Feb 23 doi: 10.5935/0004-2749.2021-0435. PMID: 38422355
Cox-2 expression in retinoblastoma.
Karim MM, Hayashi Y, Inoue M, Imai Y, Ito H, Yamamoto M
Am J Ophthalmol 2000 Mar;129(3):398-401. doi: 10.1016/s0002-9394(99)00355-4. PMID: 10704568
Neuronal and photoreceptor differentiation of retinoblastoma in culture.
Lemieux N, Leung TK, Michaud J, Milot J, Richer CL
Ophthalmic Paediatr Genet 1990 Jun;11(2):109-20. doi: 10.3109/13816819009012955. PMID: 2377349
Malignant transformation of spontaneously regressed retinoblastoma, retinoma/retinocytoma variant.
Eagle RC Jr, Shields JA, Donoso L, Milner RS
Ophthalmology 1989 Sep;96(9):1389-95. doi: 10.1016/s0161-6420(89)32714-x. PMID: 2780006

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