U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal CSF protein concentration

MedGen UID:
1380100
Concept ID:
C4476789
Finding
Synonym: Abnormal CSF protein level
 
HPO: HP:0025456

Definition

Any deviation from the normal range of a protein concentration in the cerebrospinal fluid. [from HPO]

Professional guidelines

PubMed

Benson GS, Bauer C, Hausner L, Couturier S, Lewczuk P, Peters O, Hüll M, Jahn H, Jessen F, Pantel J, Teipel SJ, Wagner M, Schuchhardt J, Wiltfang J, Kornhuber J, Frölich L
J Neural Transm (Vienna) 2022 Jun;129(5-6):477-486. Epub 2022 Jan 21 doi: 10.1007/s00702-022-02461-0. PMID: 35061102Free PMC Article
Peng HL, Hu Y, Chen HJ, Song PP, Jiang L
J Infect Public Health 2018 Mar-Apr;11(2):238-242. Epub 2017 Aug 7 doi: 10.1016/j.jiph.2017.07.007. PMID: 28797539
Antel J, Bar-Or A
J Neuroimmunol 2006 Nov;180(1-2):3-8. Epub 2006 Aug 23 doi: 10.1016/j.jneuroim.2006.06.032. PMID: 16934338

Recent clinical studies

Etiology

Longobardi A, Nicsanu R, Bellini S, Squitti R, Catania M, Tiraboschi P, Saraceno C, Ferrari C, Zanardini R, Binetti G, Di Fede G, Benussi L, Ghidoni R
Cells 2022 Jan 28;11(3) doi: 10.3390/cells11030462. PMID: 35159272Free PMC Article
Laviv Y, Kasper BS, Kasper EM
Neurosurg Rev 2018 Oct;41(4):957-968. Epub 2017 Mar 7 doi: 10.1007/s10143-017-0839-7. PMID: 28265819
Rice GI, Forte GM, Szynkiewicz M, Chase DS, Aeby A, Abdel-Hamid MS, Ackroyd S, Allcock R, Bailey KM, Balottin U, Barnerias C, Bernard G, Bodemer C, Botella MP, Cereda C, Chandler KE, Dabydeen L, Dale RC, De Laet C, De Goede CG, Del Toro M, Effat L, Enamorado NN, Fazzi E, Gener B, Haldre M, Lin JP, Livingston JH, Lourenco CM, Marques W Jr, Oades P, Peterson P, Rasmussen M, Roubertie A, Schmidt JL, Shalev SA, Simon R, Spiegel R, Swoboda KJ, Temtamy SA, Vassallo G, Vilain CN, Vogt J, Wermenbol V, Whitehouse WP, Soler D, Olivieri I, Orcesi S, Aglan MS, Zaki MS, Abdel-Salam GM, Vanderver A, Kisand K, Rozenberg F, Lebon P, Crow YJ
Lancet Neurol 2013 Dec;12(12):1159-69. Epub 2013 Oct 30 doi: 10.1016/S1474-4422(13)70258-8. PMID: 24183309Free PMC Article
Mammoser A
Semin Neurol 2012 Nov;32(5):517-24. Epub 2013 May 15 doi: 10.1055/s-0033-1334471. PMID: 23677660
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Diagnosis

Janelidze S, Bali D, Ashton NJ, Barthélemy NR, Vanbrabant J, Stoops E, Vanmechelen E, He Y, Dolado AO, Triana-Baltzer G, Pontecorvo MJ, Zetterberg H, Kolb H, Vandijck M, Blennow K, Bateman RJ, Hansson O
Brain 2023 Apr 19;146(4):1592-1601. doi: 10.1093/brain/awac333. PMID: 36087307Free PMC Article
McCarthy C, Carey BC, Trapnell BC
Am J Respir Crit Care Med 2022 May 1;205(9):1016-1035. doi: 10.1164/rccm.202112-2742SO. PMID: 35227171Free PMC Article
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article
Mammoser A
Semin Neurol 2012 Nov;32(5):517-24. Epub 2013 May 15 doi: 10.1055/s-0033-1334471. PMID: 23677660
Kolar OJ, Burkhart JE
Br J Vener Dis 1977 Aug;53(4):221-5. doi: 10.1136/sti.53.4.221. PMID: 336144Free PMC Article

Therapy

McCarthy C, Carey BC, Trapnell BC
Am J Respir Crit Care Med 2022 May 1;205(9):1016-1035. doi: 10.1164/rccm.202112-2742SO. PMID: 35227171Free PMC Article
Monine M, Norris D, Wang Y, Nestorov I
J Pharmacokinet Pharmacodyn 2021 Oct;48(5):639-654. Epub 2021 May 15 doi: 10.1007/s10928-021-09761-0. PMID: 33991294
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article
Mammoser A
Semin Neurol 2012 Nov;32(5):517-24. Epub 2013 May 15 doi: 10.1055/s-0033-1334471. PMID: 23677660
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Prognosis

Janelidze S, Bali D, Ashton NJ, Barthélemy NR, Vanbrabant J, Stoops E, Vanmechelen E, He Y, Dolado AO, Triana-Baltzer G, Pontecorvo MJ, Zetterberg H, Kolb H, Vandijck M, Blennow K, Bateman RJ, Hansson O
Brain 2023 Apr 19;146(4):1592-1601. doi: 10.1093/brain/awac333. PMID: 36087307Free PMC Article
McCarthy C, Carey BC, Trapnell BC
Am J Respir Crit Care Med 2022 May 1;205(9):1016-1035. doi: 10.1164/rccm.202112-2742SO. PMID: 35227171Free PMC Article
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Monine M, Norris D, Wang Y, Nestorov I
J Pharmacokinet Pharmacodyn 2021 Oct;48(5):639-654. Epub 2021 May 15 doi: 10.1007/s10928-021-09761-0. PMID: 33991294
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article

Clinical prediction guides

Janelidze S, Bali D, Ashton NJ, Barthélemy NR, Vanbrabant J, Stoops E, Vanmechelen E, He Y, Dolado AO, Triana-Baltzer G, Pontecorvo MJ, Zetterberg H, Kolb H, Vandijck M, Blennow K, Bateman RJ, Hansson O
Brain 2023 Apr 19;146(4):1592-1601. doi: 10.1093/brain/awac333. PMID: 36087307Free PMC Article
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Monine M, Norris D, Wang Y, Nestorov I
J Pharmacokinet Pharmacodyn 2021 Oct;48(5):639-654. Epub 2021 May 15 doi: 10.1007/s10928-021-09761-0. PMID: 33991294
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Recent systematic reviews

Domingues RB, Leite FBVM, Senne C
Arq Neuropsiquiatr 2022 Mar;80(3):296-305. doi: 10.1590/0004-282X-ANP-2021-0117. PMID: 35239818Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...