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Venom allergy

MedGen UID:
1387536
•Concept ID:
C4510560
•
Pathologic Function
Synonyms: Allergy, Insect Sting; Allergy, Insect Venom; Allergy, Venom; Hypersensitivity, Venom; Insect Sting Allergies; Insect Sting Allergy; Insect Venom Allergies; Insect Venom Allergy; Sting Allergy, Insect; Venom Allergies; Venom Allergy; Venom Allergy, Insect; Venom Hypersensitivities; Venom Hypersensitivity
SNOMED CT: Allergy to insect venom (151201000119107)
 
HPO: HP:0410336
Monarch Initiative: MONDO:0600005

Definition

Hypersensitivity in form of an adverse immune reaction against insect venom. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVenom allergy

Professional guidelines

PubMed

Immunotherapy and biologicals for the treatment of allergy to Hymenoptera stings.
Ridolo E, Pellicelli I, Kihlgren P, Nizi MC, Pucciarini F, Senna G, Incorvaia C
Expert Opin Biol Ther 2019 Sep;19(9):919-925. Epub 2019 Jun 21 doi: 10.1080/14712598.2019.1632286. PMID: 31190572
Hymenoptera Venom Allergy: Management of Children and Adults in Clinical Practice.
Bilò MB, Pravettoni V, Bignardi D, Bonadonna P, Mauro M, Novembre E, Quercia O, Cilia M, Cortellini G, Costantino MT, Cremonte L, Lodi Rizzini F, Macchia L, Marengo F, Murzilli F, Patella V, Reccardini F, Ricciardi L, Ridolo E, Romano A, Savi E, Schiavino D, Severino M, Pastorello EA
J Investig Allergol Clin Immunol 2019;29(3):180-205. Epub 2018 Sep 5 doi: 10.18176/jiaci.0310. PMID: 30183660
EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy.
Sturm GJ, Varga EM, Roberts G, Mosbech H, Bilò MB, Akdis CA, Antolín-Amérigo D, Cichocka-Jarosz E, Gawlik R, Jakob T, Kosnik M, Lange J, Mingomataj E, Mitsias DI, Ollert M, Oude Elberink JNG, Pfaar O, Pitsios C, Pravettoni V, Ruëff F, Sin BA, Agache I, Angier E, Arasi S, Calderón MA, Fernandez-Rivas M, Halken S, Jutel M, Lau S, Pajno GB, van Ree R, Ryan D, Spranger O, van Wijk RG, Dhami S, Zaman H, Sheikh A, Muraro A
Allergy 2018 Apr;73(4):744-764. Epub 2017 Dec 5 doi: 10.1111/all.13262. PMID: 28748641

Recent clinical studies

Etiology

Drug and Venom Allergy in Mastocytosis.
Giannetti MP, Nicoloro-SantaBarbara J, Godwin G, Middlesworth J, Espeland A, Castells MC
Immunol Allergy Clin North Am 2023 Nov;43(4):699-710. Epub 2023 May 22 doi: 10.1016/j.iac.2023.04.002. PMID: 37758407
Hymenoptera Venom Allergy and Anaphylaxis.
Bilò MB, Danieli MG, Moroncini G, Martini M
Curr Pharm Des 2023;29(3):165-177. doi: 10.2174/1381612828666220817091039. PMID: 35980057
Pregnancy and Hymenoptera venom allergy.
Bonadonna P, Mauro M, Preziosi D, Pravettoni V
Curr Opin Allergy Clin Immunol 2020 Oct;20(5):465-469. doi: 10.1097/ACI.0000000000000681. PMID: 32769711
Venom Immunotherapy: Questions and Controversies.
Golden DBK
Immunol Allergy Clin North Am 2020 Feb;40(1):59-68. Epub 2019 Nov 6 doi: 10.1016/j.iac.2019.09.002. PMID: 31761121
EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy.
Sturm GJ, Varga EM, Roberts G, Mosbech H, Bilò MB, Akdis CA, Antolín-Amérigo D, Cichocka-Jarosz E, Gawlik R, Jakob T, Kosnik M, Lange J, Mingomataj E, Mitsias DI, Ollert M, Oude Elberink JNG, Pfaar O, Pitsios C, Pravettoni V, Ruëff F, Sin BA, Agache I, Angier E, Arasi S, Calderón MA, Fernandez-Rivas M, Halken S, Jutel M, Lau S, Pajno GB, van Ree R, Ryan D, Spranger O, van Wijk RG, Dhami S, Zaman H, Sheikh A, Muraro A
Allergy 2018 Apr;73(4):744-764. Epub 2017 Dec 5 doi: 10.1111/all.13262. PMID: 28748641

Diagnosis

Drug and Venom Allergy in Mastocytosis.
Giannetti MP, Nicoloro-SantaBarbara J, Godwin G, Middlesworth J, Espeland A, Castells MC
Immunol Allergy Clin North Am 2023 Nov;43(4):699-710. Epub 2023 May 22 doi: 10.1016/j.iac.2023.04.002. PMID: 37758407
Severe food allergy reactions are associated with α-tryptase.
Lang A, Kubala S, Grieco MC, Mateja A, Pongracic J, Liu Y, Frischmeyer-Guerrerio PA, Kumar R, Lyons JJ
J Allergy Clin Immunol 2023 Oct;152(4):933-939. Epub 2023 Aug 7 doi: 10.1016/j.jaci.2023.07.014. PMID: 37558059Free PMC Article
Hymenoptera Venom Allergy and Anaphylaxis.
Bilò MB, Danieli MG, Moroncini G, Martini M
Curr Pharm Des 2023;29(3):165-177. doi: 10.2174/1381612828666220817091039. PMID: 35980057
Stinging Insect Allergens.
Cui L, Xu YY, Wang XJ, Guan K
Curr Protein Pept Sci 2020;21(2):142-152. doi: 10.2174/1389203720666191120130209. PMID: 31752653
Immunology of Bee Venom.
Elieh Ali Komi D, Shafaghat F, Zwiener RD
Clin Rev Allergy Immunol 2018 Jun;54(3):386-396. doi: 10.1007/s12016-017-8597-4. PMID: 28105558

Therapy

Drug and Venom Allergy in Mastocytosis.
Giannetti MP, Nicoloro-SantaBarbara J, Godwin G, Middlesworth J, Espeland A, Castells MC
Immunol Allergy Clin North Am 2023 Nov;43(4):699-710. Epub 2023 May 22 doi: 10.1016/j.iac.2023.04.002. PMID: 37758407
Hymenoptera Venom Allergy and Anaphylaxis.
Bilò MB, Danieli MG, Moroncini G, Martini M
Curr Pharm Des 2023;29(3):165-177. doi: 10.2174/1381612828666220817091039. PMID: 35980057
Pregnancy and Hymenoptera venom allergy.
Bonadonna P, Mauro M, Preziosi D, Pravettoni V
Curr Opin Allergy Clin Immunol 2020 Oct;20(5):465-469. doi: 10.1097/ACI.0000000000000681. PMID: 32769711
Venom Immunotherapy: Questions and Controversies.
Golden DBK
Immunol Allergy Clin North Am 2020 Feb;40(1):59-68. Epub 2019 Nov 6 doi: 10.1016/j.iac.2019.09.002. PMID: 31761121
EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy.
Sturm GJ, Varga EM, Roberts G, Mosbech H, Bilò MB, Akdis CA, Antolín-Amérigo D, Cichocka-Jarosz E, Gawlik R, Jakob T, Kosnik M, Lange J, Mingomataj E, Mitsias DI, Ollert M, Oude Elberink JNG, Pfaar O, Pitsios C, Pravettoni V, Ruëff F, Sin BA, Agache I, Angier E, Arasi S, Calderón MA, Fernandez-Rivas M, Halken S, Jutel M, Lau S, Pajno GB, van Ree R, Ryan D, Spranger O, van Wijk RG, Dhami S, Zaman H, Sheikh A, Muraro A
Allergy 2018 Apr;73(4):744-764. Epub 2017 Dec 5 doi: 10.1111/all.13262. PMID: 28748641

Prognosis

Severe food allergy reactions are associated with α-tryptase.
Lang A, Kubala S, Grieco MC, Mateja A, Pongracic J, Liu Y, Frischmeyer-Guerrerio PA, Kumar R, Lyons JJ
J Allergy Clin Immunol 2023 Oct;152(4):933-939. Epub 2023 Aug 7 doi: 10.1016/j.jaci.2023.07.014. PMID: 37558059Free PMC Article
Molecular diagnosis contribution for personalized medicine.
Luengo O, Galvan-Blasco P, Cardona V
Curr Opin Allergy Clin Immunol 2022 Jun 1;22(3):175-180. Epub 2022 Feb 16 doi: 10.1097/ACI.0000000000000822. PMID: 35174793
Stinging Insect Allergens.
Cui L, Xu YY, Wang XJ, Guan K
Curr Protein Pept Sci 2020;21(2):142-152. doi: 10.2174/1389203720666191120130209. PMID: 31752653
Clinical aspects of hymenoptera venom allergy and venom immunotherapy.
Bilò MB, Tontini C, Martini M, Corsi A, Agolini S, Antonicelli L
Eur Ann Allergy Clin Immunol 2019 Nov;51(6):244-258. doi: 10.23822/EurAnnACI.1764-1489.113. PMID: 31594296
Hymenoptera venom allergy.
Przybilla B, Ruëff F
J Dtsch Dermatol Ges 2010 Feb;8(2):114-27; quiz 128-30. Epub 2009 Sep 14 doi: 10.1111/j.1610-0387.2009.07125.x. PMID: 19751222

Clinical prediction guides

Severe food allergy reactions are associated with α-tryptase.
Lang A, Kubala S, Grieco MC, Mateja A, Pongracic J, Liu Y, Frischmeyer-Guerrerio PA, Kumar R, Lyons JJ
J Allergy Clin Immunol 2023 Oct;152(4):933-939. Epub 2023 Aug 7 doi: 10.1016/j.jaci.2023.07.014. PMID: 37558059Free PMC Article
Molecular diagnosis contribution for personalized medicine.
Luengo O, Galvan-Blasco P, Cardona V
Curr Opin Allergy Clin Immunol 2022 Jun 1;22(3):175-180. Epub 2022 Feb 16 doi: 10.1097/ACI.0000000000000822. PMID: 35174793
Update on Insect Sting Anaphylaxis.
Golden DBK
Curr Allergy Asthma Rep 2021 Mar 5;21(3):16. doi: 10.1007/s11882-021-00998-w. PMID: 33666774
Stinging Insect Allergens.
Cui L, Xu YY, Wang XJ, Guan K
Curr Protein Pept Sci 2020;21(2):142-152. doi: 10.2174/1389203720666191120130209. PMID: 31752653
Hymenoptera venom allergy.
Przybilla B, Ruëff F
J Dtsch Dermatol Ges 2010 Feb;8(2):114-27; quiz 128-30. Epub 2009 Sep 14 doi: 10.1111/j.1610-0387.2009.07125.x. PMID: 19751222

Recent systematic reviews

Empty mast cell syndrome: fallacy or fact?
Mohamed OE, Baretto RL, Walker I, Melchior C, Heslegrave J, Mckenzie R, Hullur C, Ekbote A, Krishna MT
J Clin Pathol 2020 May;73(5):250-256. Epub 2019 Dec 12 doi: 10.1136/jclinpath-2019-206157. PMID: 31831575
Health economic analysis of allergen immunotherapy for the management of allergic rhinitis, asthma, food allergy and venom allergy: A systematic overview.
Asaria M, Dhami S, van Ree R, Gerth van Wijk R, Muraro A, Roberts G, Sheikh A
Allergy 2018 Feb;73(2):269-283. Epub 2017 Sep 18 doi: 10.1111/all.13254. PMID: 28718981
Allergen immunotherapy for insect venom allergy: a systematic review and meta-analysis.
Dhami S, Zaman H, Varga EM, Sturm GJ, Muraro A, Akdis CA, Antolín-Amérigo D, Bilò MB, Bokanovic D, Calderon MA, Cichocka-Jarosz E, Oude Elberink JN, Gawlik R, Jakob T, Kosnik M, Lange J, Mingomataj E, Mitsias DI, Mosbech H, Ollert M, Pfaar O, Pitsios C, Pravettoni V, Roberts G, Ruëff F, Sin BA, Asaria M, Netuveli G, Sheikh A
Allergy 2017 Mar;72(3):342-365. Epub 2017 Jan 25 doi: 10.1111/all.13077. PMID: 28120424
A systematic review of the clinical effectiveness and cost-effectiveness of Pharmalgen® for the treatment of bee and wasp venom allergy.
Hockenhull J, Elremeli M, Cherry MG, Mahon J, Lai M, Darroch J, Oyee J, Boland A, Dickson R, Dundar Y, Boyle R
Health Technol Assess 2012;16(12):III-IV, 1-110. doi: 10.3310/hta16120. PMID: 22409877Free PMC Article

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