U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Medulloblastoma non-WNT/non-SHH

MedGen UID:
1387799
Concept ID:
C4330667
Neoplastic Process
Synonyms: medulloblastoma non-WNT/non-SHH; Medulloblastoma, Non-WNT/Non-SHH
 
Monarch Initiative: MONDO:0850198

Definition

Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog (SHH) pathway. TP53 mutations are absent. This molecular subtype includes medulloblastomas numerically designated as ""group 3"" and ""group 4"". [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMedulloblastoma non-WNT/non-SHH

Professional guidelines

PubMed

Pérez-Pineda PL, Ortiz-Butrón R, Pérez-De Marcos JC, Hernández-Regino LM, Zapata-Tarrés MM, Torres-Espíndola LM
CNS Neurol Disord Drug Targets 2023;22(5):634-642. doi: 10.2174/1871527321666220509141030. PMID: 35579144

Recent clinical studies

Etiology

Korshunov A, Okonechnikov K, Schrimpf D, Tonn S, Mynarek M, Koster J, Sievers P, Milde T, Sahm F, Jones DTW, von Deimling A, Pfister SM, Kool M
Acta Neuropathol 2023 Jun;145(6):829-842. Epub 2023 Apr 24 doi: 10.1007/s00401-023-02575-z. PMID: 37093271
Williamson D, Schwalbe EC, Bailey S, Clifford SC
Neuropathol Appl Neurobiol 2023 Jun;49(3):e12903. doi: 10.1111/nan.12903. PMID: 37021628Free PMC Article
Sursal T, Ronecker JS, Dicpinigaitis AJ, Mohan AL, Tobias ME, Gandhi CD, Jhanwar-Uniyal M
Anticancer Res 2022 May;42(5):2225-2239. doi: 10.21873/anticanres.15703. PMID: 35489737
Orr BA
Brain Pathol 2020 May;30(3):664-678. doi: 10.1111/bpa.12837. PMID: 32239782Free PMC Article
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article

Diagnosis

Neth BJ, Raghunathan A, Kizilbash SH, Uhm JH, Breen WG, Johnson DR, Daniels DJ, Sener U, Carabenciov ID, Campian JL, Khatua S, Mahajan A, Ruff MW
Neurology 2023 Sep 19;101(12):e1256-e1271. Epub 2023 Jul 31 doi: 10.1212/WNL.0000000000207631. PMID: 37524533Free PMC Article
Cotter JA, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):23-33. doi: 10.1177/10935266211018931. PMID: 35168417
Orr BA
Brain Pathol 2020 May;30(3):664-678. doi: 10.1111/bpa.12837. PMID: 32239782Free PMC Article
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article
Menyhárt O, Giangaspero F, Győrffy B
J Hematol Oncol 2019 Mar 15;12(1):29. doi: 10.1186/s13045-019-0712-y. PMID: 30876441Free PMC Article

Therapy

Badiger S, Gudipati A, Uppin M, Konatam ML, Yeramneni VK, Bhattacharjee S, Saradhi MV, Patnaik S, Irukulla M
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S592-S602. Epub 2023 Apr 29 doi: 10.4103/jcrt.jcrt_1268_22. PMID: 38384024
Lukoseviciute M, Theodosopoulou A, Holzhauser S, Dalianis T, Kostopoulou ON
Oncol Rep 2023 Jun;49(6) Epub 2023 May 5 doi: 10.3892/or.2023.8562. PMID: 37144508Free PMC Article
Carrie C, Kieffer V, Figarella-Branger D, Masliah-Planchon J, Bolle S, Bernier V, Laprie A, Supiot S, Leseur J, Habrand JL, Alapetite C, Kerr C, Dufour C, Claude L, Chapet S, Huchet A, Bondiau PY, Escande A, Truc G, Nguyen TD, Pasteuris C, Vigneron C, Muracciole X, Bourdeaut F, Appay R, Dubray B, Colin C, Ferlay C, Dussart S, Chabaud S, Padovani L; French Group of Pediatric Radiotherapy (GFRP); French Society of Pediatric Cancers (SFCE)
Int J Radiat Oncol Biol Phys 2020 Dec 1;108(5):1204-1217. Epub 2020 Aug 6 doi: 10.1016/j.ijrobp.2020.07.2324. PMID: 32768563
Yehia M, Taha H, Salama A, Amer N, Mosaab A, Hassanain O, Refaat A, Yassin D, El-Hemaly A, Ahmed S, El-Beltagy M, Shaalan O, El-Naggar S
Sci Rep 2019 Aug 30;9(1):12605. doi: 10.1038/s41598-019-49027-x. PMID: 31471537Free PMC Article
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article

Prognosis

Korshunov A, Okonechnikov K, Schrimpf D, Tonn S, Mynarek M, Koster J, Sievers P, Milde T, Sahm F, Jones DTW, von Deimling A, Pfister SM, Kool M
Acta Neuropathol 2023 Jun;145(6):829-842. Epub 2023 Apr 24 doi: 10.1007/s00401-023-02575-z. PMID: 37093271
Williamson D, Schwalbe EC, Bailey S, Clifford SC
Neuropathol Appl Neurobiol 2023 Jun;49(3):e12903. doi: 10.1111/nan.12903. PMID: 37021628Free PMC Article
Goddard J, Castle J, Southworth E, Fletcher A, Crosier S, Martin-Guerrero I, García-Ariza M, Navajas A, Masliah-Planchon J, Bourdeaut F, Dufour C, Ayrault O, Goschzik T, Pietsch T, Sill M, Pfister SM, Rutkowski S, Richardson S, Hill RM, Williamson D, Bailey S, Schwalbe EC, Clifford SC, Hicks D
Acta Neuropathol 2023 May;145(5):651-666. Epub 2023 Apr 4 doi: 10.1007/s00401-023-02566-0. PMID: 37014508Free PMC Article
Sursal T, Ronecker JS, Dicpinigaitis AJ, Mohan AL, Tobias ME, Gandhi CD, Jhanwar-Uniyal M
Anticancer Res 2022 May;42(5):2225-2239. doi: 10.21873/anticanres.15703. PMID: 35489737
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article

Clinical prediction guides

Massimino M, Vennarini S, Buttarelli FR, Antonelli M, Colombo F, Minasi S, Pecori E, Ferroli P, Giussani C, Schiariti M, Schiavello E, Biassoni V, Erbetta A, Chiapparini L, Nigro O, Boschetti L, Gianno F, Miele E, Modena P, De Cecco L, Pollo B, Barretta F
J Neurooncol 2023 Jul;163(3):577-586. Epub 2023 Jun 16 doi: 10.1007/s11060-023-04361-z. PMID: 37326761
Korshunov A, Okonechnikov K, Schrimpf D, Tonn S, Mynarek M, Koster J, Sievers P, Milde T, Sahm F, Jones DTW, von Deimling A, Pfister SM, Kool M
Acta Neuropathol 2023 Jun;145(6):829-842. Epub 2023 Apr 24 doi: 10.1007/s00401-023-02575-z. PMID: 37093271
Williamson D, Schwalbe EC, Bailey S, Clifford SC
Neuropathol Appl Neurobiol 2023 Jun;49(3):e12903. doi: 10.1111/nan.12903. PMID: 37021628Free PMC Article
Goddard J, Castle J, Southworth E, Fletcher A, Crosier S, Martin-Guerrero I, García-Ariza M, Navajas A, Masliah-Planchon J, Bourdeaut F, Dufour C, Ayrault O, Goschzik T, Pietsch T, Sill M, Pfister SM, Rutkowski S, Richardson S, Hill RM, Williamson D, Bailey S, Schwalbe EC, Clifford SC, Hicks D
Acta Neuropathol 2023 May;145(5):651-666. Epub 2023 Apr 4 doi: 10.1007/s00401-023-02566-0. PMID: 37014508Free PMC Article
Delaidelli A, Dunham C, Santi M, Negri GL, Triscott J, Zheludkova O, Golanov A, Ryzhova M, Okonechnikov K, Schrimpf D, Stichel D, Ellison DW, von Deimling A, Kool M, Pfister SM, Ramaswamy V, Korshunov A, Taylor MD, Sorensen PH
Clin Cancer Res 2022 Jan 1;28(1):116-128. Epub 2021 Oct 26 doi: 10.1158/1078-0432.CCR-21-2057. PMID: 34702771

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...