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Abnormal morphology of the olfactory bulb

MedGen UID:
1388809
•Concept ID:
C4477050
•
Anatomical Abnormality
HPO: HP:0040327

Definition

An abnormal morphology of the olfactory bulb (bulbus olfactorius), which is involved in olfaction, i.e. the sense of smell. [from HPO]

Professional guidelines

PubMed

Phenotype and genotype analysis of a French cohort of 119 patients with CHARGE syndrome.
Legendre M, Abadie V, Attié-Bitach T, Philip N, Busa T, Bonneau D, Colin E, Dollfus H, Lacombe D, Toutain A, Blesson S, Julia S, Martin-Coignard D, Geneviève D, Leheup B, Odent S, Jouk PS, Mercier S, Faivre L, Vincent-Delorme C, Francannet C, Naudion S, Mathieu-Dramard M, Delrue MA, Goldenberg A, Héron D, Parent P, Touraine R, Layet V, Sanlaville D, Quélin C, Moutton S, Fradin M, Jacquette A, Sigaudy S, Pinson L, Sarda P, Guerrot AM, Rossi M, Masurel-Paulet A, El Chehadeh S, Piguel X, Rodriguez-Ballesteros M, Ragot S, Lyonnet S, Bilan F, Gilbert-Dussardier B
Am J Med Genet C Semin Med Genet 2017 Dec;175(4):417-430. Epub 2017 Nov 27 doi: 10.1002/ajmg.c.31591. PMID: 29178447
Early treatment of Kallmann syndrome may prevent eunuchoid appearance and behavior.
Castañeyra-Perdomo A, Castañeyra-Ruiz L, González-Marrero I, Castañeyra-Ruiz A, Gonzalez-Toledo JM, Castañeyra-Ruiz M, Carmona-Calero EM
Med Hypotheses 2014 Jan;82(1):74-6. Epub 2013 Nov 16 doi: 10.1016/j.mehy.2013.11.011. PMID: 24296236
Kallmann syndrome caused by mutations in the PROK2 and PROKR2 genes: pathophysiology and genotype-phenotype correlations.
Sarfati J, Dodé C, Young J
Front Horm Res 2010;39:121-132. Epub 2010 Apr 8 doi: 10.1159/000312698. PMID: 20389090

Recent clinical studies

Etiology

Reduced olfactory bulb volume and olfactory sulcus depth in obsessive compulsive disorder.
Kapici OB, Kapici Y, Tekin A
Psychiatry Res Neuroimaging 2023 Jul;332:111644. Epub 2023 Apr 10 doi: 10.1016/j.pscychresns.2023.111644. PMID: 37087810
Involvement of the Olfactory Apparatus by Gliomas.
Wu X, Li Y, Glastonbury CM, Cha S
AJNR Am J Neuroradiol 2020 Apr;41(4):712-717. Epub 2020 Mar 12 doi: 10.3174/ajnr.A6471. PMID: 32165363Free PMC Article
Expression of α-synuclein is regulated in a neuronal cell type-dependent manner.
Taguchi K, Watanabe Y, Tsujimura A, Tanaka M
Anat Sci Int 2019 Jan;94(1):11-22. Epub 2018 Oct 25 doi: 10.1007/s12565-018-0464-8. PMID: 30362073Free PMC Article
Pediatric anosmia: A case series.
Hauser LJ, Jensen EL, Mirsky DM, Chan KH
Int J Pediatr Otorhinolaryngol 2018 Jul;110:135-139. Epub 2018 May 17 doi: 10.1016/j.ijporl.2018.05.011. PMID: 29859575
Structural anomalies of the peripheral olfactory system in psychosis high-risk subjects.
Turetsky BI, Moberg PJ, Quarmley M, Dress E, Calkins ME, Ruparel K, Prabhakaran K, Gur RE, Roalf DR
Schizophr Res 2018 May;195:197-205. Epub 2017 Sep 30 doi: 10.1016/j.schres.2017.09.015. PMID: 28974405Free PMC Article

Diagnosis

Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder?
Sancaktar M, Kocamer Şahin Ş, Demir B, Elboğa U, Elboğa G, Altındağ A
J Neural Transm (Vienna) 2023 Feb;130(2):145-152. Epub 2023 Jan 21 doi: 10.1007/s00702-023-02587-9. PMID: 36680695Free PMC Article
Olfactory Development, Part 2: Neuroanatomic Maturation and Dysgeneses.
Sarnat HB, Flores-Sarnat L
J Child Neurol 2017 May;32(6):579-593. Epub 2017 Feb 19 doi: 10.1177/0883073816685192. PMID: 28424008
Olfaction and Aging: A Mini-Review.
Attems J, Walker L, Jellinger KA
Gerontology 2015;61(6):485-90. Epub 2015 May 9 doi: 10.1159/000381619. PMID: 25968962
The olfactory system.
Leboucq N, Menjot de Champfleur N, Menjot de Champfleur S, Bonafé A
Diagn Interv Imaging 2013 Oct;94(10):985-91. Epub 2013 Aug 7 doi: 10.1016/j.diii.2013.06.006. PMID: 23932763
How to measure olfactory bulb volume and olfactory sulcus depth?
Rombaux P, Grandin C, Duprez T
B-ENT 2009;5 Suppl 13:53-60. PMID: 20084805

Therapy

Olfactory Neuroepithelium Cells from Cannabis Users Display Alterations to the Cytoskeleton and to Markers of Adhesion, Proliferation and Apoptosis.
Delgado-Sequera A, Hidalgo-Figueroa M, Barrera-Conde M, Duran-Ruiz MC, Castro C, Fernández-Avilés C, de la Torre R, Sánchez-Gomar I, Pérez V, Geribaldi-Doldán N, Robledo P, Berrocoso E
Mol Neurobiol 2021 Apr;58(4):1695-1710. Epub 2020 Nov 25 doi: 10.1007/s12035-020-02205-9. PMID: 33237429
Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.
Rey NL, George S, Steiner JA, Madaj Z, Luk KC, Trojanowski JQ, Lee VM, Brundin P
Acta Neuropathol 2018 Jan;135(1):65-83. Epub 2017 Dec 5 doi: 10.1007/s00401-017-1792-9. PMID: 29209768Free PMC Article
Olfactory bulb volume and olfactory function after radiotherapy in patients with nasopharyngeal cancer.
Veyseller B, Ozucer B, Degirmenci N, Gurbuz D, Tambas M, Altun M, Aksoy F, Ozturan O
Auris Nasus Larynx 2014 Oct;41(5):436-40. Epub 2014 Apr 17 doi: 10.1016/j.anl.2014.02.004. PMID: 24746667
Therapeutic effect of exogenous hsp70 in mouse models of Alzheimer's disease.
Bobkova NV, Garbuz DG, Nesterova I, Medvinskaya N, Samokhin A, Alexandrova I, Yashin V, Karpov V, Kukharsky MS, Ninkina NN, Smirnov AA, Nudler E, Evgen'ev M
J Alzheimers Dis 2014;38(2):425-35. doi: 10.3233/JAD-130779. PMID: 23985416
Reduced olfactory bulb volume and diminished olfactory function in total laryngectomy patients: a prospective longitudinal study.
Veyseller B, Ozucer B, Aksoy F, Yildirim YS, Gürbüz D, Balikçi HH, Ozturan O
Am J Rhinol Allergy 2012 May-Jun;26(3):191-3. doi: 10.2500/ajra.2012.26.3768. PMID: 22643943

Prognosis

Structural anomalies of the peripheral olfactory system in psychosis high-risk subjects.
Turetsky BI, Moberg PJ, Quarmley M, Dress E, Calkins ME, Ruparel K, Prabhakaran K, Gur RE, Roalf DR
Schizophr Res 2018 May;195:197-205. Epub 2017 Sep 30 doi: 10.1016/j.schres.2017.09.015. PMID: 28974405Free PMC Article
Olfactory Development, Part 2: Neuroanatomic Maturation and Dysgeneses.
Sarnat HB, Flores-Sarnat L
J Child Neurol 2017 May;32(6):579-593. Epub 2017 Feb 19 doi: 10.1177/0883073816685192. PMID: 28424008
Persistent primitive olfactory artery: CT angiographic diagnosis and literature review for classification and clinical significance.
Kim MS, Lee GJ
Surg Radiol Anat 2014 Sep;36(7):663-7. Epub 2013 Nov 23 doi: 10.1007/s00276-013-1239-5. PMID: 24271941
Altered depth of the olfactory sulcus in first-episode schizophrenia.
Takahashi T, Nakamura Y, Nakamura K, Ikeda E, Furuichi A, Kido M, Kawasaki Y, Noguchi K, Seto H, Suzuki M
Prog Neuropsychopharmacol Biol Psychiatry 2013 Jan 10;40:167-72. Epub 2012 Oct 9 doi: 10.1016/j.pnpbp.2012.10.001. PMID: 23063493
Stages in the development of Parkinson's disease-related pathology.
Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K
Cell Tissue Res 2004 Oct;318(1):121-34. Epub 2004 Aug 24 doi: 10.1007/s00441-004-0956-9. PMID: 15338272

Clinical prediction guides

Reduced olfactory bulb volume and olfactory sulcus depth in obsessive compulsive disorder.
Kapici OB, Kapici Y, Tekin A
Psychiatry Res Neuroimaging 2023 Jul;332:111644. Epub 2023 Apr 10 doi: 10.1016/j.pscychresns.2023.111644. PMID: 37087810
Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder?
Sancaktar M, Kocamer Şahin Ş, Demir B, Elboğa U, Elboğa G, Altındağ A
J Neural Transm (Vienna) 2023 Feb;130(2):145-152. Epub 2023 Jan 21 doi: 10.1007/s00702-023-02587-9. PMID: 36680695Free PMC Article
Clinical and Radiological Profiles of COVID-19 Patients with Neurological Symptomatology: A Comparative Study.
Aragao MFVV, Leal MC, Andrade PHP, Cartaxo Filho OQ, Aragao LV, Fonseca TM, Valenca MA, Leao MRVC, Aragao JPV, Soares ML, Lima MP, Caldas SS, Valenca MM
Viruses 2021 May 6;13(5) doi: 10.3390/v13050845. PMID: 34066524Free PMC Article
Structural anomalies of the peripheral olfactory system in psychosis high-risk subjects.
Turetsky BI, Moberg PJ, Quarmley M, Dress E, Calkins ME, Ruparel K, Prabhakaran K, Gur RE, Roalf DR
Schizophr Res 2018 May;195:197-205. Epub 2017 Sep 30 doi: 10.1016/j.schres.2017.09.015. PMID: 28974405Free PMC Article
Stages in the development of Parkinson's disease-related pathology.
Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K
Cell Tissue Res 2004 Oct;318(1):121-34. Epub 2004 Aug 24 doi: 10.1007/s00441-004-0956-9. PMID: 15338272

Recent systematic reviews

Magnetic Resonance Imaging as a Diagnostic and Research Tool in Patients with Olfactory Dysfunction: A Systematic Review.
Hura N, Yi JS, Lin SY, Roxbury CR
Am J Rhinol Allergy 2022 Sep;36(5):668-683. Epub 2022 May 18 doi: 10.1177/19458924221096913. PMID: 35585698
Retronasal Olfaction Test Methods: A Systematic Review.
Özay H, Çakır A, Ecevit MC
Balkan Med J 2019 Jan 1;36(1):49-59. Epub 2018 Sep 28 doi: 10.4274/balkanmedj.2018.0052. PMID: 30264731Free PMC Article

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