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Anaplastic/large cell medulloblastoma

MedGen UID:
1389864
•Concept ID:
C4330531
•
Neoplastic Process
Synonym: Large Cell/Anaplastic Medulloblastoma
SNOMED CT: Anaplastic large cell medulloblastoma (1197356004)
 
Monarch Initiative: MONDO:0016709
Orphanet: ORPHA251855

Definition

A histological variant of medulloblastoma, an embryonic malignancy, associated with extremely low survival rates and a high risk of metastatic disease and manifesting with symptoms of increased intracranial pressure such as vomiting, headache, listlessness, papilledema and diplopia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic/large cell medulloblastoma

Professional guidelines

PubMed

Childhood medulloblastoma: the paradigm shift in molecular stratification and treatment profile.
Sadighi Z, Vats T, Khatua S
J Child Neurol 2012 Oct;27(10):1302-7. Epub 2012 Jul 22 doi: 10.1177/0883073812449690. PMID: 22826514

Recent clinical studies

Etiology

Surgical management of posterior fossa medulloblastoma in children: The Lyon experience.
Grassiot B, Beuriat PA, Di Rocco F, Leblond P, Faure-Conter C, Szathmari A, Mottolese C
Neurochirurgie 2021 Feb;67(1):52-60. Epub 2021 Jan 19 doi: 10.1016/j.neuchi.2021.01.003. PMID: 33482236
The gut or the brain?--Gastrointestinal misdiagnoses of infantile brain tumors.
Teo WY, Myseros JS
Childs Nerv Syst 2014 Aug;30(8):1449-53. Epub 2014 Feb 18 doi: 10.1007/s00381-014-2386-7. PMID: 24535228
Histological variants of medulloblastoma are the most powerful clinical prognostic indicators.
Massimino M, Antonelli M, Gandola L, Miceli R, Pollo B, Biassoni V, Schiavello E, Buttarelli FR, Spreafico F, Collini P, Giangaspero F
Pediatr Blood Cancer 2013 Feb;60(2):210-6. Epub 2012 Jun 12 doi: 10.1002/pbc.24225. PMID: 22693015

Diagnosis

Surgical management of posterior fossa medulloblastoma in children: The Lyon experience.
Grassiot B, Beuriat PA, Di Rocco F, Leblond P, Faure-Conter C, Szathmari A, Mottolese C
Neurochirurgie 2021 Feb;67(1):52-60. Epub 2021 Jan 19 doi: 10.1016/j.neuchi.2021.01.003. PMID: 33482236
The gut or the brain?--Gastrointestinal misdiagnoses of infantile brain tumors.
Teo WY, Myseros JS
Childs Nerv Syst 2014 Aug;30(8):1449-53. Epub 2014 Feb 18 doi: 10.1007/s00381-014-2386-7. PMID: 24535228
Histological variants of medulloblastoma are the most powerful clinical prognostic indicators.
Massimino M, Antonelli M, Gandola L, Miceli R, Pollo B, Biassoni V, Schiavello E, Buttarelli FR, Spreafico F, Collini P, Giangaspero F
Pediatr Blood Cancer 2013 Feb;60(2):210-6. Epub 2012 Jun 12 doi: 10.1002/pbc.24225. PMID: 22693015
Histologic features and prognosis in pediatric medulloblastoma.
Verma S, Tavaré CJ, Gilles FH
Pediatr Dev Pathol 2008 Sep-Oct;11(5):337-43. Epub 2008 Jan 17 doi: 10.2350/07-09-0353.1. PMID: 18201118

Prognosis

Surgical management of posterior fossa medulloblastoma in children: The Lyon experience.
Grassiot B, Beuriat PA, Di Rocco F, Leblond P, Faure-Conter C, Szathmari A, Mottolese C
Neurochirurgie 2021 Feb;67(1):52-60. Epub 2021 Jan 19 doi: 10.1016/j.neuchi.2021.01.003. PMID: 33482236
Cerebellar swelling after surgery for medulloblastoma with leptomeningeal dissemination in children. A case based-update.
Todeschi J, Stella I, Entz-Werle N, Coca HA, Joud A, Chastagner P, Proust F, Klein O
Neurochirurgie 2021 Apr;67(2):145-151. Epub 2020 Dec 16 doi: 10.1016/j.neuchi.2020.11.015. PMID: 33340509
Histological variants of medulloblastoma are the most powerful clinical prognostic indicators.
Massimino M, Antonelli M, Gandola L, Miceli R, Pollo B, Biassoni V, Schiavello E, Buttarelli FR, Spreafico F, Collini P, Giangaspero F
Pediatr Blood Cancer 2013 Feb;60(2):210-6. Epub 2012 Jun 12 doi: 10.1002/pbc.24225. PMID: 22693015
Histologic features and prognosis in pediatric medulloblastoma.
Verma S, Tavaré CJ, Gilles FH
Pediatr Dev Pathol 2008 Sep-Oct;11(5):337-43. Epub 2008 Jan 17 doi: 10.2350/07-09-0353.1. PMID: 18201118

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