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Increased reactive oxygen species production

MedGen UID:
1390274
Concept ID:
C4476796
Cell or Molecular Dysfunction
Synonyms: Increased ROS production; Oxidative stress
 
HPO: HP:0025464

Definition

An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased reactive oxygen species production

Recent clinical studies

Etiology

Ren B, Li D, Si L, Ding Y, Han J, Chen X, Zheng Q
J Pharm Pharmacol 2018 Apr;70(4):516-524. Epub 2018 Feb 7 doi: 10.1111/jphp.12879. PMID: 29411391
Hurtado-Nedelec M, Csillag-Grange MJ, Boussetta T, Belambri SA, Fay M, Cassinat B, Gougerot-Pocidalo MA, Dang PM, El-Benna J
Haematologica 2013 Oct;98(10):1517-24. Epub 2013 Aug 23 doi: 10.3324/haematol.2012.082560. PMID: 23975181Free PMC Article
Sam F, Kerstetter DL, Pimental DR, Mulukutla S, Tabaee A, Bristow MR, Colucci WS, Sawyer DB
J Card Fail 2005 Aug;11(6):473-80. doi: 10.1016/j.cardfail.2005.01.007. PMID: 16105639
Saleh RA, Agarwal A, Kandirali E, Sharma RK, Thomas AJ, Nada EA, Evenson DP, Alvarez JG
Fertil Steril 2002 Dec;78(6):1215-24. doi: 10.1016/s0015-0282(02)04237-1. PMID: 12477515
Shapiro RH, Muller CH, Chen G, Berger RE
J Urol 1998 Oct;160(4):1341-6. PMID: 9751351

Diagnosis

Kushwaha PP, Vardhan PS, Kapewangolo P, Shuaib M, Prajapati SK, Singh AK, Kumar S
Life Sci 2019 Oct 1;234:116783. Epub 2019 Aug 21 doi: 10.1016/j.lfs.2019.116783. PMID: 31442552
Chen CC, Hong HJ, Hao WR, Cheng TH, Liu JC, Sung LC
Eur J Pharmacol 2019 Sep 15;859:172542. Epub 2019 Jul 16 doi: 10.1016/j.ejphar.2019.172542. PMID: 31319070
Kim J, Chen CH, Yang J, Mochly-Rosen D
J Biomed Sci 2017 May 22;24(1):33. doi: 10.1186/s12929-017-0338-8. PMID: 28532411Free PMC Article
Lefort N, Glancy B, Bowen B, Willis WT, Bailowitz Z, De Filippis EA, Brophy C, Meyer C, Højlund K, Yi Z, Mandarino LJ
Diabetes 2010 Oct;59(10):2444-52. Epub 2010 Aug 3 doi: 10.2337/db10-0174. PMID: 20682693Free PMC Article
Saleh RA, Agarwal A, Kandirali E, Sharma RK, Thomas AJ, Nada EA, Evenson DP, Alvarez JG
Fertil Steril 2002 Dec;78(6):1215-24. doi: 10.1016/s0015-0282(02)04237-1. PMID: 12477515

Therapy

Qiu N, Du X, Ji J, Zhai G
Drug Dev Ind Pharm 2021 Jun;47(6):839-856. Epub 2021 Jun 24 doi: 10.1080/03639045.2021.1934869. PMID: 34033496
Casagrande N, Borghese C, Favero A, Vicenzetto C, Aldinucci D
Cancer Lett 2021 Mar 1;500:182-193. Epub 2020 Dec 14 doi: 10.1016/j.canlet.2020.12.015. PMID: 33326840
Noël A, Hossain E, Perveen Z, Zaman H, Penn AL
Respir Res 2020 Nov 19;21(1):305. doi: 10.1186/s12931-020-01571-1. PMID: 33213456Free PMC Article
Naime ACA, Bonfitto PHL, Solon C, Lopes-Pires ME, Anhê GF, Antunes E, Marcondes S
Platelets 2019;30(8):1047-1052. Epub 2019 May 10 doi: 10.1080/09537104.2019.1588241. PMID: 31076004
Ren B, Li D, Si L, Ding Y, Han J, Chen X, Zheng Q
J Pharm Pharmacol 2018 Apr;70(4):516-524. Epub 2018 Feb 7 doi: 10.1111/jphp.12879. PMID: 29411391

Prognosis

Vigorelli V, Resta J, Bianchessi V, Lauri A, Bassetti B, Agrifoglio M, Pesce M, Polvani G, Bonalumi G, Cavallotti L, Alamanni F, Genovese S, Pompilio G, Vinci MC
J Am Heart Assoc 2019 May 7;8(9):e010012. doi: 10.1161/JAHA.118.010012. PMID: 31018749Free PMC Article
Rio S, Gastou M, Karboul N, Derman R, Suriyun T, Manceau H, Leblanc T, El Benna J, Schmitt C, Azouzi S, Larghéro J, Karim Z, Macias-Garcia A, Chen JJ, Hermine O, Courtois G, Puy H, Gouya L, Mohandas N, Da Costa L
Blood 2019 Mar 21;133(12):1358-1370. Epub 2019 Jan 30 doi: 10.1182/blood-2018-09-875674. PMID: 30700418Free PMC Article
Dong Y, Lagarde J, Xicota L, Corne H, Chantran Y, Chaigneau T, Crestani B, Bottlaender M, Potier MC, Aucouturier P, Dorothée G, Sarazin M, Elbim C
Ann Neurol 2018 Feb;83(2):387-405. doi: 10.1002/ana.25159. PMID: 29369398
Sahoo A, Lee B, Boniface K, Seneschal J, Sahoo SK, Seki T, Wang C, Das S, Han X, Steppie M, Seal S, Taieb A, Perera RJ
J Invest Dermatol 2017 Sep;137(9):1965-1974. Epub 2017 May 11 doi: 10.1016/j.jid.2017.04.025. PMID: 28502800Free PMC Article
Tang S, Le PK, Tse S, Wallace DC, Huang T
PLoS One 2009;4(2):e4492. Epub 2009 Feb 16 doi: 10.1371/journal.pone.0004492. PMID: 19221591Free PMC Article

Clinical prediction guides

Lledó VE, Alkozi HA, Sánchez-Naves J, Fernandez-Torres MA, Guzman-Aranguez A
J Photochem Photobiol B 2021 Aug;221:112248. Epub 2021 Jun 23 doi: 10.1016/j.jphotobiol.2021.112248. PMID: 34192628
Sumiyoshi M, Miyazaki T, Makau JN, Mizuta S, Tanaka Y, Ishikawa T, Makimura K, Hirayama T, Takazono T, Saijo T, Yamaguchi H, Shimamura S, Yamamoto K, Imamura Y, Sakamoto N, Obase Y, Izumikawa K, Yanagihara K, Kohno S, Mukae H
Sci Rep 2020 Oct 20;10(1):17745. doi: 10.1038/s41598-020-74749-8. PMID: 33082485Free PMC Article
Naime ACA, Bonfitto PHL, Solon C, Lopes-Pires ME, Anhê GF, Antunes E, Marcondes S
Platelets 2019;30(8):1047-1052. Epub 2019 May 10 doi: 10.1080/09537104.2019.1588241. PMID: 31076004
Sam F, Kerstetter DL, Pimental DR, Mulukutla S, Tabaee A, Bristow MR, Colucci WS, Sawyer DB
J Card Fail 2005 Aug;11(6):473-80. doi: 10.1016/j.cardfail.2005.01.007. PMID: 16105639
Saleh RA, Agarwal A, Kandirali E, Sharma RK, Thomas AJ, Nada EA, Evenson DP, Alvarez JG
Fertil Steril 2002 Dec;78(6):1215-24. doi: 10.1016/s0015-0282(02)04237-1. PMID: 12477515

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