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Abnormality of redox activity

MedGen UID:
1393465
•Concept ID:
C4476795
•
Cell or Molecular Dysfunction
HPO: HP:0025463

Definition

An abnormality of the processes that maintain the redox environment of a cell or compartment within a cell, that is, the balance between reduction and oxidation chemical reactions. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of redox activity

Professional guidelines

PubMed

Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome.
Kagan VE, Tyurina YY, Mikulska-Ruminska K, Damschroder D, Vieira Neto E, Lasorsa A, Kapralov AA, Tyurin VA, Amoscato AA, Samovich SN, Souryavong AB, Dar HH, Ramim A, Liang Z, Lazcano P, Ji J, Schmidtke MW, Kiselyov K, Korkmaz A, Vladimirov GK, Artyukhova MA, Rampratap P, Cole LK, Niyatie A, Baker EK, Peterson J, Hatch GM, Atkinson J, Vockley J, Kühn B, Wessells R, van der Wel PCA, Bahar I, Bayir H, Greenberg ML
Nat Metab 2023 Dec;5(12):2184-2205. Epub 2023 Nov 23 doi: 10.1038/s42255-023-00926-4. PMID: 37996701
U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia.
Crawley WT, Jungels CG, Stenmark KR, Fini MA
Redox Biol 2022 May;51:102271. Epub 2022 Feb 17 doi: 10.1016/j.redox.2022.102271. PMID: 35228125Free PMC Article
Oxidative stress in the pathology and treatment of systemic lupus erythematosus.
Perl A
Nat Rev Rheumatol 2013 Nov;9(11):674-86. Epub 2013 Oct 8 doi: 10.1038/nrrheum.2013.147. PMID: 24100461Free PMC Article

Recent clinical studies

Etiology

The Redox Protein High-Mobility Group Box 1 in Cell Death and Cancer.
Chen R, Zou J, Kang R, Tang D
Antioxid Redox Signal 2023 Sep;39(7-9):569-590. Epub 2023 Mar 30 doi: 10.1089/ars.2023.0236. PMID: 36999916
Outlook of Ferroptosis-Targeted Lipid Peroxidation in Cardiovascular Disease.
Wu ZF, Liu XY, Deng NH, Ren Z, Jiang ZS
Curr Med Chem 2023;30(31):3550-3561. doi: 10.2174/0929867330666221111162905. PMID: 36372915
U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia.
Crawley WT, Jungels CG, Stenmark KR, Fini MA
Redox Biol 2022 May;51:102271. Epub 2022 Feb 17 doi: 10.1016/j.redox.2022.102271. PMID: 35228125Free PMC Article
Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts.
Zhu HL, Shi XT, Xu XF, Zhou GX, Xiong YW, Yi SJ, Liu WB, Dai LM, Cao XL, Xu DX, Wang H
Redox Biol 2021 Apr;40:101854. Epub 2021 Jan 6 doi: 10.1016/j.redox.2021.101854. PMID: 33454563Free PMC Article
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Diagnosis

Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy.
Nenkov M, Ma Y, Gaßler N, Chen Y
Int J Mol Sci 2021 Jun 10;22(12) doi: 10.3390/ijms22126262. PMID: 34200820Free PMC Article
The role of mitochondrial dysfunction in cardiovascular disease: a brief review.
Chistiakov DA, Shkurat TP, Melnichenko AA, Grechko AV, Orekhov AN
Ann Med 2018 Mar;50(2):121-127. Epub 2017 Dec 18 doi: 10.1080/07853890.2017.1417631. PMID: 29237304
Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195
Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.
Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL
Chest 2017 Jan;151(1):181-192. Epub 2016 Sep 16 doi: 10.1016/j.chest.2016.09.001. PMID: 27645688Free PMC Article
Metabolic features of the cell danger response.
Naviaux RK
Mitochondrion 2014 May;16:7-17. Epub 2013 Aug 24 doi: 10.1016/j.mito.2013.08.006. PMID: 23981537

Therapy

Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia.
Fang K, Sun M, Leng Z, Chu Y, Zhao Z, Li Z, Zhang Y, Xu A, Zhang Z, Zhang L, Chen T, Xu M
J Exp Clin Cancer Res 2023 Mar 28;42(1):73. doi: 10.1186/s13046-023-02623-2. PMID: 36978187Free PMC Article
Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models.
Zhang X, Li LX, Ding H, Torres VE, Yu C, Li X
J Am Soc Nephrol 2021 Nov;32(11):2759-2776. doi: 10.1681/ASN.2021040460. PMID: 34716241Free PMC Article
Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.
Kang Q, Yang C
Redox Biol 2020 Oct;37:101799. Epub 2020 Nov 13 doi: 10.1016/j.redox.2020.101799. PMID: 33248932Free PMC Article
Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility.
Lin X, Dai Y, Tong X, Xu W, Huang Q, Jin X, Li C, Zhou F, Zhou H, Lin X, Huang D, Zhang S
Redox Biol 2020 Feb;30:101431. Epub 2020 Jan 12 doi: 10.1016/j.redox.2020.101431. PMID: 31972508Free PMC Article
Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195

Prognosis

Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.
Knight H, Abis G, Kaur M, Green HLH, Krasemann S, Hartmann K, Lynham S, Clark J, Zhao L, Ruppert C, Weiss A, Schermuly RT, Eaton P, Rudyk O
Circ Res 2023 Dec 8;133(12):966-988. Epub 2023 Nov 13 doi: 10.1161/CIRCRESAHA.122.321836. PMID: 37955182Free PMC Article
Unravelling the role of NFE2L1 in stress responses and related diseases.
Liu X, Xu C, Xiao W, Yan N
Redox Biol 2023 Sep;65:102819. Epub 2023 Jul 14 doi: 10.1016/j.redox.2023.102819. PMID: 37473701Free PMC Article
Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia.
Fang K, Sun M, Leng Z, Chu Y, Zhao Z, Li Z, Zhang Y, Xu A, Zhang Z, Zhang L, Chen T, Xu M
J Exp Clin Cancer Res 2023 Mar 28;42(1):73. doi: 10.1186/s13046-023-02623-2. PMID: 36978187Free PMC Article
Expert consensus document: Mitochondrial function as a therapeutic target in heart failure.
Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, Cleland JG, Colucci WS, Butler J, Voors AA, Anker SD, Pitt B, Pieske B, Filippatos G, Greene SJ, Gheorghiade M
Nat Rev Cardiol 2017 Apr;14(4):238-250. Epub 2016 Dec 22 doi: 10.1038/nrcardio.2016.203. PMID: 28004807Free PMC Article
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Clinical prediction guides

Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.
Knight H, Abis G, Kaur M, Green HLH, Krasemann S, Hartmann K, Lynham S, Clark J, Zhao L, Ruppert C, Weiss A, Schermuly RT, Eaton P, Rudyk O
Circ Res 2023 Dec 8;133(12):966-988. Epub 2023 Nov 13 doi: 10.1161/CIRCRESAHA.122.321836. PMID: 37955182Free PMC Article
Development of KEAP1-targeting PROTAC and its antioxidant properties: In vitro and in vivo.
Park SY, Gurung R, Hwang JH, Kang JH, Jung HJ, Zeb A, Hwang JI, Park SJ, Maeng HJ, Shin D, Oh SH
Redox Biol 2023 Aug;64:102783. Epub 2023 Jun 15 doi: 10.1016/j.redox.2023.102783. PMID: 37348157Free PMC Article
U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia.
Crawley WT, Jungels CG, Stenmark KR, Fini MA
Redox Biol 2022 May;51:102271. Epub 2022 Feb 17 doi: 10.1016/j.redox.2022.102271. PMID: 35228125Free PMC Article
Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts.
Zhu HL, Shi XT, Xu XF, Zhou GX, Xiong YW, Yi SJ, Liu WB, Dai LM, Cao XL, Xu DX, Wang H
Redox Biol 2021 Apr;40:101854. Epub 2021 Jan 6 doi: 10.1016/j.redox.2021.101854. PMID: 33454563Free PMC Article
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Recent systematic reviews

The role of nuclear factor erythroid 2-related factor 2 (NRF2) in normal and pathological pregnancy: A systematic review.
Tantengco OAG, de Castro Silva M, Shahin H, Bento GFC, Cursino GC, Cayenne S, da Silva MG, Menon R
Am J Reprod Immunol 2021 Dec;86(6):e13496. Epub 2021 Sep 19 doi: 10.1111/aji.13496. PMID: 34467607
Oxidative Stress in the Early Stage of Psychosis.
Ventriglio A, Bellomo A, Donato F, Iris B, Giovanna V, Dario DS, Edwige C, Di Gioia Ilaria, Pettorruso M, Perna G, Valchera A, De Berardis D
Curr Top Med Chem 2021 Oct 25;21(16):1457-1470. doi: 10.2174/1568026621666210701105839. PMID: 34218786
Glutathione levels and activities of glutathione metabolism enzymes in patients with schizophrenia: A systematic review and meta-analysis.
Tsugawa S, Noda Y, Tarumi R, Mimura Y, Yoshida K, Iwata Y, Elsalhy M, Kuromiya M, Kurose S, Masuda F, Morita S, Ogyu K, Plitman E, Wada M, Miyazaki T, Graff-Guerrero A, Mimura M, Nakajima S
J Psychopharmacol 2019 Oct;33(10):1199-1214. Epub 2019 Apr 30 doi: 10.1177/0269881119845820. PMID: 31039654
Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta-Analysis, and In Silico Integrated Approach.
Mendonça AAS, Coelho CM, Veloso MP, Caldas IS, Gonçalves RV, Teixeira AL, de Miranda AS, Novaes RD
Oxid Med Cell Longev 2018;2018:8676578. Epub 2018 Oct 24 doi: 10.1155/2018/8676578. PMID: 30473742Free PMC Article

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