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Dyssynergia

MedGen UID:
13945
•Concept ID:
C0004134
•
Sign or Symptom
Synonym: Ataxia
SNOMED CT: Ataxia (loss of muscle coordination) (20262006); Ataxia (20262006); Dyssynergia (39384006)
 
HPO: HP:0010867

Definition

A type of ataxia characterized by the impairment of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed. With dyssynergia, a voluntary movement appears broken down into its component parts. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDyssynergia

Professional guidelines

PubMed

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.
Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Pathophysiological basis, clinical assessment, investigation and management of patients with obstruction defecation syndrome.
Bunni J, Laugharne MJ
Langenbecks Arch Surg 2023 Feb 2;408(1):75. doi: 10.1007/s00423-023-02755-1. PMID: 36729157
The international anorectal physiology working group (IAPWG) recommendations: Standardized testing protocol and the London classification for disorders of anorectal function.
Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R, Chey WD, Chiarioni G, Dinning P, Emmanuel A, Farouk R, Felt-Bersma RJF, Jung KW, Lembo A, Malcolm A, Mittal RK, Mion F, Myung SJ, O'Connell PR, Pehl C, Remes-Troche JM, Reveille RM, Vaizey CJ, Vitton V, Whitehead WE, Wong RK, Scott SM; All members of the International Anorectal Physiology Working Group
Neurogastroenterol Motil 2020 Jan;32(1):e13679. Epub 2019 Aug 12 doi: 10.1111/nmo.13679. PMID: 31407463Free PMC Article

Recent clinical studies

Etiology

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.
Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
The international anorectal physiology working group (IAPWG) recommendations: Standardized testing protocol and the London classification for disorders of anorectal function.
Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R, Chey WD, Chiarioni G, Dinning P, Emmanuel A, Farouk R, Felt-Bersma RJF, Jung KW, Lembo A, Malcolm A, Mittal RK, Mion F, Myung SJ, O'Connell PR, Pehl C, Remes-Troche JM, Reveille RM, Vaizey CJ, Vitton V, Whitehead WE, Wong RK, Scott SM; All members of the International Anorectal Physiology Working Group
Neurogastroenterol Motil 2020 Jan;32(1):e13679. Epub 2019 Aug 12 doi: 10.1111/nmo.13679. PMID: 31407463Free PMC Article
Epidemiology and pathophysiology of neurogenic bladder after spinal cord injury.
Hamid R, Averbeck MA, Chiang H, Garcia A, Al Mousa RT, Oh SJ, Patel A, Plata M, Del Popolo G
World J Urol 2018 Oct;36(10):1517-1527. Epub 2018 May 11 doi: 10.1007/s00345-018-2301-z. PMID: 29752515
Diagnosis and clinical evaluation of neurogenic bladder.
Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046
Constipation in Parkinson's Disease.
Stocchi F, Torti M
Int Rev Neurobiol 2017;134:811-826. Epub 2017 Jul 13 doi: 10.1016/bs.irn.2017.06.003. PMID: 28805584

Diagnosis

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.
Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Abdominophrenic Dyssynergia: A Narrative Review.
Damianos JA, Tomar SK, Azpiroz F, Barba E
Am J Gastroenterol 2023 Jan 1;118(1):41-45. Epub 2022 Sep 30 doi: 10.14309/ajg.0000000000002044. PMID: 36191283Free PMC Article
Solitary rectal ulcer syndrome.
Felt-Bersma RJF
Curr Opin Gastroenterol 2021 Jan;37(1):59-65. doi: 10.1097/MOG.0000000000000689. PMID: 33060396
Diagnosis and clinical evaluation of neurogenic bladder.
Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046
Constipation in Parkinson's Disease.
Stocchi F, Torti M
Int Rev Neurobiol 2017;134:811-826. Epub 2017 Jul 13 doi: 10.1016/bs.irn.2017.06.003. PMID: 28805584

Therapy

Non-pharmacologic approach to pediatric constipation.
Santucci NR, Chogle A, Leiby A, Mascarenhas M, Borlack RE, Lee A, Perez M, Russell A, Yeh AM
Complement Ther Med 2021 Jun;59:102711. Epub 2021 Mar 15 doi: 10.1016/j.ctim.2021.102711. PMID: 33737146
A Review of Botulinum Toxin A for the Treatment of Neurogenic Bladder.
Cooley LF, Kielb S
PM R 2019 Feb;11(2):192-200. Epub 2019 Feb 13 doi: 10.1016/j.pmrj.2018.07.016. PMID: 30138720
Noninvasive Cerebellar Stimulation as a Complement Tool to Pharmacotherapy.
Ferrucci R, Bocci T, Cortese F, Ruggiero F, Priori A
Curr Neuropharmacol 2019;17(1):14-20. doi: 10.2174/1570159X15666171114142422. PMID: 29141551Free PMC Article
Constipation in Parkinson's Disease.
Stocchi F, Torti M
Int Rev Neurobiol 2017;134:811-826. Epub 2017 Jul 13 doi: 10.1016/bs.irn.2017.06.003. PMID: 28805584
Urologic applications of botulinum toxin.
King A, Quirouet A, Moore CK
Cleve Clin J Med 2015 Jul;82(7):456-64. doi: 10.3949/ccjm.82a.13166. PMID: 26185945

Prognosis

Constipation in Parkinson's Disease.
Quigley EMM
Semin Neurol 2023 Aug;43(4):562-571. Epub 2023 Aug 14 doi: 10.1055/s-0043-1771457. PMID: 37579786
Deep Learning of Videourodynamics to Classify Bladder Dysfunction Severity in Patients With Spina Bifida.
Weaver JK, Martin-Olenski M, Logan J, Broms R, Antony M, Van Batavia J, Weiss DA, Long CJ, Smith AL, Zderic SA, Huang J, Fan Y, Tasian GE
J Urol 2023 May;209(5):994-1003. Epub 2023 Feb 14 doi: 10.1097/JU.0000000000003267. PMID: 36787376
Pharmacotherapeutic management of lower urinary tract symptoms in Multiple Sclerosis patients.
Zanghì A, Cimino S, Urzì D, Privitera S, Zagari F, Lanza G, Patti F, D'Amico E
Expert Opin Pharmacother 2020 Aug;21(12):1449-1454. Epub 2020 May 26 doi: 10.1080/14656566.2020.1767068. PMID: 32452702
The management of paediatric neurogenic bladder: an approach in a resource-poor setting.
Maison POM, Lazarus J
Paediatr Int Child Health 2017 Nov;37(4):280-285. Epub 2017 Jul 17 doi: 10.1080/20469047.2017.1351745. PMID: 28714784
Role of permanent stents.
Badlani GH
J Endourol 1997 Dec;11(6):473-5. doi: 10.1089/end.1997.11.473. PMID: 9440859

Clinical prediction guides

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review.
Moshiree B, Drossman D, Shaukat A
Gastroenterology 2023 Sep;165(3):791-800.e3. Epub 2023 Jul 13 doi: 10.1053/j.gastro.2023.04.039. PMID: 37452811
Abdomino-anal Dyscoordination in Defecatory Disorders.
Srinivasan SG, Muthyala A, Sharma M, Feuerhak K, Boon A, Bailey KR, Bharucha AE
Clin Gastroenterol Hepatol 2022 Sep;20(9):2091-2101.e5. Epub 2021 Dec 8 doi: 10.1016/j.cgh.2021.11.040. PMID: 34896282Free PMC Article
Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder.
Kour S, Rajan DS, Fortuna TR, Anderson EN, Ward C, Lee Y, Lee S, Shin YB, Chae JH, Choi M, Siquier K, Cantagrel V, Amiel J, Stolerman ES, Barnett SS, Cousin MA, Castro D, McDonald K, Kirmse B, Nemeth AH, Rajasundaram D, Innes AM, Lynch D, Frosk P, Collins A, Gibbons M, Yang M, Desguerre I, Boddaert N, Gitiaux C, Rydning SL, Selmer KK, Urreizti R, Garcia-Oguiza A, Osorio AN, Verdura E, Pujol A, McCurry HR, Landers JE, Agnihotri S, Andriescu EC, Moody SB, Phornphutkul C, Sacoto MJG, Begtrup A, Houlden H, Kirschner J, Schorling D, Rudnik-Schöneborn S, Strom TM, Leiz S, Juliette K, Richardson R, Yang Y, Zhang Y, Wang M, Wang J, Wang X, Platzer K, Donkervoort S, Bönnemann CG, Wagner M, Issa MY, Elbendary HM, Stanley V, Maroofian R, Gleeson JG, Zaki MS, Senderek J, Pandey UB
Nat Commun 2021 May 7;12(1):2558. doi: 10.1038/s41467-021-22627-w. PMID: 33963192Free PMC Article
Gastrointestinal Uses of Botulinum Toxin.
Cariati M, Chiarello MM, Cannistra' M, Lerose MA, Brisinda G
Handb Exp Pharmacol 2021;263:185-226. doi: 10.1007/164_2019_326. PMID: 32072269
Symptomatic myoclonus.
Borg M
Neurophysiol Clin 2006 Sep-Dec;36(5-6):309-18. Epub 2007 Jan 17 doi: 10.1016/j.neucli.2006.12.006. PMID: 17336775

Recent systematic reviews

The effect of biofeedback interventions on pain, overall symptoms, quality of life and physiological parameters in patients with pelvic pain : A systematic review.
Wagner B, Steiner M, Huber DFX, Crevenna R
Wien Klin Wochenschr 2022 Jan;134(Suppl 1):11-48. Epub 2021 Mar 22 doi: 10.1007/s00508-021-01827-w. PMID: 33751183Free PMC Article
Botulinum toxin type A for the treatment of dyssynergic defaecation in adults: a systematic review.
Chaichanavichkij P, Vollebregt PF, Scott SM, Knowles CH
Colorectal Dis 2020 Dec;22(12):1832-1841. Epub 2020 Jun 11 doi: 10.1111/codi.15120. PMID: 32403161
Biomarkers to distinguish functional constipation from irritable bowel syndrome with constipation.
Whitehead WE, Palsson OS, Simrén M
Neurogastroenterol Motil 2016 Jun;28(6):783-92. doi: 10.1111/nmo.12852. PMID: 27214096
Iatrogenic urological triggers of autonomic dysreflexia: a systematic review.
Liu N, Zhou M, Biering-Sørensen F, Krassioukov AV
Spinal Cord 2015 Jul;53(7):500-9. Epub 2015 Mar 24 doi: 10.1038/sc.2015.39. PMID: 25800696
An updated systematic review and statistical comparison of standardised mean outcomes for the use of botulinum toxin in the management of lower urinary tract disorders.
Mangera A, Apostolidis A, Andersson KE, Dasgupta P, Giannantoni A, Roehrborn C, Novara G, Chapple C
Eur Urol 2014 May;65(5):981-90. Epub 2013 Nov 1 doi: 10.1016/j.eururo.2013.10.033. PMID: 24239446

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    Related information

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