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Benign gastrointestinal tract tumors

MedGen UID:
141680
•Concept ID:
C0497538
•
Neoplastic Process
Synonyms: alimentary part of gastrointestinal system benign neoplasm; Benign Digestive System Neoplasm; benign digestive system neoplasm; Benign Digestive System Tumor; benign digestive system tumor; benign digestive system tumour; Benign Gastrointestinal Neoplasm; benign gastrointestinal neoplasm; Benign Gastrointestinal System Tumor; benign gastrointestinal system tumor; benign gastrointestinal system tumour; Benign gastrointestinal tract tumours; Benign Gastrointestinal Tumor; benign gastrointestinal tumor; benign gastrointestinal tumour; Benign GI Neoplasm; benign GI neoplasm; Benign GI System Neoplasm; benign GI system neoplasm; Benign GI System Tumor; benign GI system tumor; benign GI system tumour; Benign GI tract tumors; Benign GI tract tumours; Benign GI Tumor; benign GI tumor; benign GI tumour; Benign Neoplasm of Digestive System; benign neoplasm of digestive system; Benign Neoplasm of Gastrointestinal System; benign neoplasm of gastrointestinal system; Benign neoplasm of gastrointestinal tract; Benign Neoplasm of the Digestive System; benign neoplasm of the digestive system; Benign Tumor of Digestive System; benign tumor of digestive system; Benign Tumor of Gastrointestinal System; benign tumor of gastrointestinal system; Benign tumor of gastrointestinal tract; Benign Tumor of GI System; benign tumor of GI system; Benign Tumor of the Digestive System; benign tumor of the digestive system; Benign Tumor of the Gastrointestinal System; benign tumor of the gastrointestinal system; Benign Tumor of the GI System; benign tumor of the GI system; benign tumour of digestive system; benign tumour of gastrointestinal system; benign tumour of GI system; benign tumour of the digestive system; benign tumour of the gastrointestinal system; benign tumour of the GI system; gastrointestinal system benign neoplasm; Non-cancerous GI tumors; Non-cancerous GI tumours
SNOMED CT: Benign neoplasm of gastrointestinal tract (92118007); Benign tumor of gastrointestinal tract (92118007)
 
HPO: HP:0006719
Monarch Initiative: MONDO:0000385

Definition

A neoplasm that arises from the digestive system and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign gastrointestinal tract tumors

Conditions with this feature

Muir-Torré syndrome
MedGen UID:
231157
•Concept ID:
C1321489
•
Neoplastic Process
Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.
See: Condition Record
Muir-Torré syndrome

Professional guidelines

PubMed

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions.
Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, Shami VM
Am J Gastroenterol 2023 Jan 1;118(1):46-58. Epub 2022 Sep 6 doi: 10.14309/ajg.0000000000002100. PMID: 36602835
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Management of post-hepatectomy complications.
Jin S, Fu Q, Wuyun G, Wuyun T
World J Gastroenterol 2013 Nov 28;19(44):7983-91. doi: 10.3748/wjg.v19.i44.7983. PMID: 24307791Free PMC Article

Recent clinical studies

Etiology

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Cystic lesions of the parotid gland: radiologic-pathologic correlation according to the latest World Health Organization 2017 Classification of Head and Neck Tumours.
Takita H, Takeshita T, Shimono T, Tanaka H, Iguchi H, Hashimoto S, Kuwae Y, Ohsawa M, Miki Y
Jpn J Radiol 2017 Nov;35(11):629-647. Epub 2017 Aug 23 doi: 10.1007/s11604-017-0678-z. PMID: 28836142
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Diagnosis

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Cystic lesions of the parotid gland: radiologic-pathologic correlation according to the latest World Health Organization 2017 Classification of Head and Neck Tumours.
Takita H, Takeshita T, Shimono T, Tanaka H, Iguchi H, Hashimoto S, Kuwae Y, Ohsawa M, Miki Y
Jpn J Radiol 2017 Nov;35(11):629-647. Epub 2017 Aug 23 doi: 10.1007/s11604-017-0678-z. PMID: 28836142
Retrorectal tumors.
Bullard Dunn K
Surg Clin North Am 2010 Feb;90(1):163-71, Table of Contents. doi: 10.1016/j.suc.2009.09.009. PMID: 20109640

Therapy

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial.
Wang M, Li D, Chen R, Huang X, Li J, Liu Y, Liu J, Cheng W, Chen X, Zhao W, Li J, Tan Z, Huang H, Li D, Zhu F, Qin T, Ma J, Yu G, Zhou B, Zheng S, Tang Y, Han W, Meng L, Ke J, Feng F, Chen B, Yin X, Chen W, Ma H, Xu J, Liu Y, Lin R, Dong Y, Yu Y, Liu J, Zhang H, Qin R; Minimally Invasive Treatment Group in the Pancreatic Disease Branch of China's International Exchange and Promotion Association for Medicine and Healthcare (MITG-P-CPAM)
Lancet Gastroenterol Hepatol 2021 Jun;6(6):438-447. Epub 2021 Apr 27 doi: 10.1016/S2468-1253(21)00054-6. PMID: 33915091
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Paraneoplastic pemphigus.
Yong AA, Tey HL
Australas J Dermatol 2013 Nov;54(4):241-50. Epub 2012 Jul 3 doi: 10.1111/j.1440-0960.2012.00921.x. PMID: 22759072
Primary gastrointestinal lymphoma.
Ghimire P, Wu GY, Zhu L
World J Gastroenterol 2011 Feb 14;17(6):697-707. doi: 10.3748/wjg.v17.i6.697. PMID: 21390139Free PMC Article
Gastrointestinal stromal tumors.
Casper ES
Curr Treat Options Oncol 2000 Aug;1(3):267-73. doi: 10.1007/s11864-000-0039-4. PMID: 12057170

Prognosis

T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.
van Vliet C, Spagnolo DV
Pathology 2020 Jan;52(1):128-141. Epub 2019 Nov 11 doi: 10.1016/j.pathol.2019.10.001. PMID: 31727264
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Retrorectal tumors.
Bullard Dunn K
Surg Clin North Am 2010 Feb;90(1):163-71, Table of Contents. doi: 10.1016/j.suc.2009.09.009. PMID: 20109640
Carcinoid tumors.
Pasieka JL
Surg Clin North Am 2009 Oct;89(5):1123-37. doi: 10.1016/j.suc.2009.06.008. PMID: 19836488
Gastrointestinal stromal tumors.
Casper ES
Curr Treat Options Oncol 2000 Aug;1(3):267-73. doi: 10.1007/s11864-000-0039-4. PMID: 12057170

Clinical prediction guides

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Update on the mesentery: structure, function, and role in disease.
Coffey JC, Byrnes KG, Walsh DJ, Cunningham RM
Lancet Gastroenterol Hepatol 2022 Jan;7(1):96-106. Epub 2021 Nov 22 doi: 10.1016/S2468-1253(21)00179-5. PMID: 34822760
State-of-the-Art Imaging of Salivary Gland Tumors.
Abdel Razek AAK, Mukherji SK
Neuroimaging Clin N Am 2018 May;28(2):303-317. doi: 10.1016/j.nic.2018.01.009. PMID: 29622121
Evaluation: Imaging Studies.
Kontzialis M, Glastonbury CM, Aygun N
Adv Otorhinolaryngol 2016;78:25-38. Epub 2016 Apr 12 doi: 10.1159/000442122. PMID: 27093072
Gastrointestinal stromal tumors: epidemiology, clinical picture, diagnosis, prognosis and treatment.
Cichoz-Lach H, Kasztelan-Szczerbińska B, Słomka M
Pol Arch Med Wewn 2008 Apr;118(4):216-21. PMID: 18575421

Recent systematic reviews

Duodenum-Preserving Pancreatic Head Resection for Benign and Premalignant Tumors-a Systematic Review and Meta-analysis of Surgery-Associated Morbidity.
Beger HG, Mayer B, Poch B
J Gastrointest Surg 2023 Nov;27(11):2611-2627. Epub 2023 Sep 5 doi: 10.1007/s11605-023-05789-4. PMID: 37670106Free PMC Article
Surgical interventions for management of benign parotid tumors: Systematic review and network meta-analysis.
Mashrah MA, Al-Sharani HM, Al-Aroomi MA, Abdelrehem A, Aldhohrah T, Wang L
Head Neck 2021 Nov;43(11):3631-3645. Epub 2021 Jul 20 doi: 10.1002/hed.26813. PMID: 34288212
Prevalence and characteristics of gastric remnant cancer: A systematic review and meta-analysis.
Mak TK, Guan B, Peng J, Chong TH, Wang C, Huang S, Yang J
Asian J Surg 2021 Jan;44(1):11-17. Epub 2020 Apr 3 doi: 10.1016/j.asjsur.2020.03.012. PMID: 32253109
A systematic review of minimally invasive surgery for retrorectal tumors.
Mullaney TG, Lightner AL, Johnston M, Kelley SR, Larson DW, Dozois EJ
Tech Coloproctol 2018 Apr;22(4):255-263. Epub 2018 Apr 20 doi: 10.1007/s10151-018-1781-6. PMID: 29679245
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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