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Neurenteric cyst

MedGen UID:
14343
•Concept ID:
C0027806
•
Congenital Abnormality
Synonyms: Cyst, Neurenteric; Cyst, Neuroenteric; Cysts, Neurenteric; Cysts, Neuroenteric; Neurenteric Cyst; Neurenteric Cysts; Neuroenteric Cyst; Neuroenteric Cysts
SNOMED CT: Neurenteric cyst (789120001); Neurenteric cyst (41353005)
 
HPO: HP:0030725
Monarch Initiative: MONDO:0017087
Orphanet: ORPHA268865

Definition

The neurenteric cyst is a rare lesion composed of heterotopic endodermal tissue. During the third week of human embryogenesis, the neurenteric canal unites the yolk sac and the amniotic cavity as it traverses the primitive notochordal plate. Persistence of the normally transient neurenteric canal prevents appropriate separation of endoderm and notochord. This results in a variable degree of communication between neural and enteric epithelium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurenteric cyst
Follow this link to review classifications for Neurenteric cyst in Orphanet.

Professional guidelines

PubMed

Update on prenatal diagnosis and fetal surgery for myelomeningocele.
Meller C, Covini D, Aiello H, Izbizky G, Portillo Medina S, Otaño L
Arch Argent Pediatr 2021 Jun;119(3):e215-e228. doi: 10.5546/aap.2021.eng.e215. PMID: 34033426
Spina Bifida Management.
Phillips LA, Burton JM, Evans SH
Curr Probl Pediatr Adolesc Health Care 2017 Jul;47(7):173-177. Epub 2017 Jul 19 doi: 10.1016/j.cppeds.2017.06.007. PMID: 28734746
MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature.
Levin BL, Varga E
J Genet Couns 2016 Oct;25(5):901-11. Epub 2016 Apr 30 doi: 10.1007/s10897-016-9956-7. PMID: 27130656

Recent clinical studies

Etiology

Neurenteric cysts, incidence and surgical treatment.
Kozak J, Bizik I, Surkala J, Steno J, Steno A
Bratisl Lek Listy 2019;120(9):680-685. doi: 10.4149/BLL_2019_114. PMID: 31475554
Prenatal diagnosis of mediastinal neurenteric cyst: a case report and review of the literature.
Çay A, Aydoğdu İ, Mirapoglu SL, Toprak H
J Med Ultrason (2001) 2018 Oct;45(4):633-639. Epub 2018 Feb 21 doi: 10.1007/s10396-018-0869-y. PMID: 29468491
Neurenteric Cyst or Neuroendodermal Cyst? Immunohistochemical Study and Pathogenesis.
Chen CT, Lai HY, Jung SM, Lee CY, Wu CT, Lee ST
World Neurosurg 2016 Dec;96:85-90. Epub 2016 Aug 29 doi: 10.1016/j.wneu.2016.08.089. PMID: 27586176
Neurenteric cyst presenting with stridor and dysphagia: case report and literature review.
Visvanathan V, Crowther J, Taylor W
Scott Med J 2015 Feb;60(1):e4-7. Epub 2014 Dec 3 doi: 10.1177/0036933014563239. PMID: 25471489
Abdominal neurenteric cyst.
Colović R, Micev M, Jovanović M, Matić S, Grubor N, Atkinson HD
World J Gastroenterol 2008 Jun 21;14(23):3759-62. doi: 10.3748/wjg.14.3759. PMID: 18595146Free PMC Article

Diagnosis

Nonneoplastic and noninfective cysts of the central nervous system: A histopathological study.
Poyuran R, Kalaparti VSVG, Thomas B, Kesavapisharady K, Narasimhaiah D
Neuropathology 2023 Jun;43(3):221-232. Epub 2022 Oct 10 doi: 10.1111/neup.12867. PMID: 36210745
Giant Craniospinal Intramedullary Neurenteric Cyst in Infant-Case Report and Review of Literature.
Diyora B, Bhende B, Kukreja S
World Neurosurg 2018 Oct;118:126-131. Epub 2018 Aug 4 doi: 10.1016/j.wneu.2018.07.027. PMID: 30010074
Prenatal diagnosis of mediastinal neurenteric cyst: a case report and review of the literature.
Çay A, Aydoğdu İ, Mirapoglu SL, Toprak H
J Med Ultrason (2001) 2018 Oct;45(4):633-639. Epub 2018 Feb 21 doi: 10.1007/s10396-018-0869-y. PMID: 29468491
Neurenteric Cyst or Neuroendodermal Cyst? Immunohistochemical Study and Pathogenesis.
Chen CT, Lai HY, Jung SM, Lee CY, Wu CT, Lee ST
World Neurosurg 2016 Dec;96:85-90. Epub 2016 Aug 29 doi: 10.1016/j.wneu.2016.08.089. PMID: 27586176
Neurenteric cyst presenting with stridor and dysphagia: case report and literature review.
Visvanathan V, Crowther J, Taylor W
Scott Med J 2015 Feb;60(1):e4-7. Epub 2014 Dec 3 doi: 10.1177/0036933014563239. PMID: 25471489

Therapy

Risk Factors in a Pediatric Population for Postoperative Intracranial Infection Following Endoscopic Endonasal Skull Base Surgery and the Role of Antibiotic Prophylaxis.
Palmieri D, Champagne PO, Valappil B, McDowell MM, Gardner PA, Snyderman CH
Am J Rhinol Allergy 2023 Jan;37(1):13-18. Epub 2022 Sep 1 doi: 10.1177/19458924221123113. PMID: 36050937
Supratentorial Neurenteric Cysts: Systematic Literature Review and Case Report.
Stopa BM, Cuoco JA, Stump MS, Rogers CM
World Neurosurg 2022 Aug;164:8-24. Epub 2022 Apr 20 doi: 10.1016/j.wneu.2022.04.057. PMID: 35460907
Management of an unusual, recurrent neurenteric cyst in an infant: case report and review of the literature.
Esfahani DR, Burokas L, Brown HG, Hahn YS, Nikas D
Childs Nerv Syst 2017 Sep;33(9):1603-1607. Epub 2017 Jun 22 doi: 10.1007/s00381-017-3487-x. PMID: 28643040
Successful treatment of recurrent abdominopelvic neurenteric cysts by OK-432 injection.
Kabs C, Boschert J, Back W, Dietmar D, Hosie S
J Pediatr Surg 2009 May;44(5):1019-21. doi: 10.1016/j.jpedsurg.2008.12.036. PMID: 19433191
Surgical approaches: postoperative care and complications "posterolateral-far lateral transcondylar approach to the ventral foramen magnum and upper cervical spinal canal".
Menezes AH
Childs Nerv Syst 2008 Oct;24(10):1203-7. Epub 2008 Mar 26 doi: 10.1007/s00381-008-0597-5. PMID: 18365213

Prognosis

Neurenteric cysts, incidence and surgical treatment.
Kozak J, Bizik I, Surkala J, Steno J, Steno A
Bratisl Lek Listy 2019;120(9):680-685. doi: 10.4149/BLL_2019_114. PMID: 31475554
Prenatal diagnosis of mediastinal neurenteric cyst: a case report and review of the literature.
Çay A, Aydoğdu İ, Mirapoglu SL, Toprak H
J Med Ultrason (2001) 2018 Oct;45(4):633-639. Epub 2018 Feb 21 doi: 10.1007/s10396-018-0869-y. PMID: 29468491
Supratentorial Neurenteric Cysts: Case Series and Review of Pathology, Imaging, and Clinical Management.
Chakraborty S, Priamo F, Loven T, Li J, Insinga S, Schulder M
World Neurosurg 2016 Jan;85:143-52. Epub 2015 Sep 1 doi: 10.1016/j.wneu.2015.08.057. PMID: 26341448
Spinal Neurenteric Cyst in Association with Klippel-Feil Syndrome: Case Report and Literature Review.
Can A, Dos Santos Rubio EJ, Jasperse B, Verdijk RM, Harhangi BS
World Neurosurg 2015 Aug;84(2):592.e9-14. Epub 2015 Mar 17 doi: 10.1016/j.wneu.2015.03.015. PMID: 25790871
Neurenteric cyst presenting with stridor and dysphagia: case report and literature review.
Visvanathan V, Crowther J, Taylor W
Scott Med J 2015 Feb;60(1):e4-7. Epub 2014 Dec 3 doi: 10.1177/0036933014563239. PMID: 25471489

Clinical prediction guides

Giant Craniospinal Intramedullary Neurenteric Cyst in Infant-Case Report and Review of Literature.
Diyora B, Bhende B, Kukreja S
World Neurosurg 2018 Oct;118:126-131. Epub 2018 Aug 4 doi: 10.1016/j.wneu.2018.07.027. PMID: 30010074
Clinical presentation and surgical outcomes of intramedullary neurenteric cysts.
Yang T, Wu L, Fang J, Yang C, Deng X, Xu Y
J Neurosurg Spine 2015 Jul;23(1):99-110. Epub 2015 Apr 24 doi: 10.3171/2014.11.SPINE14352. PMID: 25909275
Diagnostic and surgical implications of ventral vertebrobasilar displacement by posterior fossa neurenteric cysts.
Uschold T, Xu DS, Wilson DA, Abla AA, Nakaji P, Spetzler RF, Chang SW
World Neurosurg 2014 Sep-Oct;82(3-4):480-4. Epub 2013 Oct 16 doi: 10.1016/j.wneu.2013.10.037. PMID: 24141002
Spectrum of nonterminal myelocystoceles.
Rossi A, Piatelli G, Gandolfo C, Pavanello M, Hoffmann C, Van Goethem JW, Cama A, Tortori-Donati P
Neurosurgery 2006 Mar;58(3):509-15; discussion 509-15. doi: 10.1227/01.NEU.0000197122.92954.82. PMID: 16528191
Infantile hypoventilation syndrome, neurenteric cyst, and syringobulbia.
Chung HD, DeMello DE, D'Souza N, Estrada J
Neurology 1982 Apr;32(4):441-4. doi: 10.1212/wnl.32.4.441. PMID: 7038532

Recent systematic reviews

Supratentorial Neurenteric Cysts: Systematic Literature Review and Case Report.
Stopa BM, Cuoco JA, Stump MS, Rogers CM
World Neurosurg 2022 Aug;164:8-24. Epub 2022 Apr 20 doi: 10.1016/j.wneu.2022.04.057. PMID: 35460907

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