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Neuroma

MedGen UID:
14352
•Concept ID:
C0027858
•
Neoplastic Process
Synonym: Neuromas
SNOMED CT: Neuroma (443892003); Neuroma (1163436007)
 
HPO: HP:0030430
Monarch Initiative: MONDO:0002173

Definition

A tumor made up of nerve cells and nerve fibers. [from HPO]

Professional guidelines

PubMed

Neuropathic Pain: From Mechanisms to Treatment.
Finnerup NB, Kuner R, Jensen TS
Physiol Rev 2021 Jan 1;101(1):259-301. Epub 2020 Jun 25 doi: 10.1152/physrev.00045.2019. PMID: 32584191
Heel Pain: Diagnosis and Management.
Tu P
Am Fam Physician 2018 Jan 15;97(2):86-93. PMID: 29365222
Etiology, diagnosis, and management of facial palsy: 2000 patients at a facial nerve center.
Hohman MH, Hadlock TA
Laryngoscope 2014 Jul;124(7):E283-93. Epub 2014 Jan 15 doi: 10.1002/lary.24542. PMID: 24431233

Recent clinical studies

Etiology

Vestibular Schwannoma: What We Know and Where We are Heading.
Gupta VK, Thakker A, Gupta KK
Head Neck Pathol 2020 Dec;14(4):1058-1066. Epub 2020 Mar 30 doi: 10.1007/s12105-020-01155-x. PMID: 32232723Free PMC Article
Etiology and Treatment Outcomes for Sural Neuroma.
Lans J, Gamo L, DiGiovanni CW, Chen NC, Eberlin KR
Foot Ankle Int 2019 May;40(5):545-552. Epub 2019 Feb 2 doi: 10.1177/1071100719828375. PMID: 30712380
Metatarsalgia.
Hodes A, Umans H
Radiol Clin North Am 2018 Nov;56(6):877-892. doi: 10.1016/j.rcl.2018.06.004. PMID: 30322488
Treatment of Morton's neuroma: A systematic review.
Valisena S, Petri GJ, Ferrero A
Foot Ankle Surg 2018 Aug;24(4):271-281. Epub 2017 Apr 5 doi: 10.1016/j.fas.2017.03.010. PMID: 29409240
Acoustic neuroma.
Consens Statement 1991 Dec 11-13;9(4):1-24. PMID: 1840823

Diagnosis

Vestibular Schwannomas.
Carlson ML, Link MJ
N Engl J Med 2021 Apr 8;384(14):1335-1348. doi: 10.1056/NEJMra2020394. PMID: 33826821
Morton's neuroma: review of anatomy, pathomechanism, and imaging.
Mak MS, Chowdhury R, Johnson R
Clin Radiol 2021 Mar;76(3):235.e15-235.e23. Epub 2020 Nov 7 doi: 10.1016/j.crad.2020.10.006. PMID: 33168237
Vestibular Schwannoma: What We Know and Where We are Heading.
Gupta VK, Thakker A, Gupta KK
Head Neck Pathol 2020 Dec;14(4):1058-1066. Epub 2020 Mar 30 doi: 10.1007/s12105-020-01155-x. PMID: 32232723Free PMC Article
Neuroma.
Neumeister MW, Winters JN
Clin Plast Surg 2020 Apr;47(2):279-283. Epub 2020 Jan 31 doi: 10.1016/j.cps.2019.12.008. PMID: 32115053
Acoustic neuroma.
Consens Statement 1991 Dec 11-13;9(4):1-24. PMID: 1840823

Therapy

A Critical Overview of Targeted Therapies for Vestibular Schwannoma.
Tamura R, Toda M
Int J Mol Sci 2022 May 13;23(10) doi: 10.3390/ijms23105462. PMID: 35628268Free PMC Article
Vestibular Schwannomas.
Carlson ML, Link MJ
N Engl J Med 2021 Apr 8;384(14):1335-1348. doi: 10.1056/NEJMra2020394. PMID: 33826821
Non-surgical treatments for Morton's neuroma: A systematic review.
Thomson L, Aujla RS, Divall P, Bhatia M
Foot Ankle Surg 2020 Oct;26(7):736-743. Epub 2019 Nov 2 doi: 10.1016/j.fas.2019.09.009. PMID: 31718949
Targeted Muscle Reinnervation Treats Neuroma and Phantom Pain in Major Limb Amputees: A Randomized Clinical Trial.
Dumanian GA, Potter BK, Mioton LM, Ko JH, Cheesborough JE, Souza JM, Ertl WJ, Tintle SM, Nanos GP, Valerio IL, Kuiken TA, Apkarian AV, Porter K, Jordan SW
Ann Surg 2019 Aug;270(2):238-246. doi: 10.1097/SLA.0000000000003088. PMID: 30371518
Treatment of Morton's neuroma: A systematic review.
Valisena S, Petri GJ, Ferrero A
Foot Ankle Surg 2018 Aug;24(4):271-281. Epub 2017 Apr 5 doi: 10.1016/j.fas.2017.03.010. PMID: 29409240

Prognosis

A glance at the past.
Ganz JC
Prog Brain Res 2022;268(1):1-8. Epub 2021 Dec 14 doi: 10.1016/bs.pbr.2021.10.022. PMID: 35074076
Incidence, Diagnosis, and Management of Neuromas Following Radiofrequency Ablation Treatment: a Narrative Review.
Schmidt S, Karri J, Singh M, Abd-Elsayed A
Curr Pain Headache Rep 2021 May 7;25(7):45. doi: 10.1007/s11916-021-00964-1. PMID: 33961177
Vestibular Schwannomas.
Carlson ML, Link MJ
N Engl J Med 2021 Apr 8;384(14):1335-1348. doi: 10.1056/NEJMra2020394. PMID: 33826821
Radiation therapy for vestibular schwannomas.
Mulder JJ, Kaanders JH, van Overbeeke JJ, Cremers CW
Curr Opin Otolaryngol Head Neck Surg 2012 Oct;20(5):367-71. doi: 10.1097/MOO.0b013e328357d337. PMID: 22931906
Hearing preservation: microsurgery.
Kari E, Friedman RA
Curr Opin Otolaryngol Head Neck Surg 2012 Oct;20(5):358-66. doi: 10.1097/MOO.0b013e3283579673. PMID: 22929113

Clinical prediction guides

Interdigital Commissural Approach for Morton's Neuroma.
Yañez Arauz JM
Foot Ankle Int 2020 Oct;41(10):1226-1233. Epub 2020 Jul 16 doi: 10.1177/1071100720936599. PMID: 32674597
Fatigue in patients with vestibular schwannoma.
Dhayalan D, Lund-Johansen M, Finnkirk M, Tveiten ØV
Acta Neurochir (Wien) 2019 Sep;161(9):1809-1816. Epub 2019 Jul 18 doi: 10.1007/s00701-019-04003-2. PMID: 31321539
Prediction of Clinical Prognosis according to Intermetatarsal Distance and Neuroma Size on Ultrasonography in Morton Neuroma: A Prospective Observational Study.
Park YH, Kim TJ, Choi GW, Kim HJ
J Ultrasound Med 2019 Apr;38(4):1009-1014. Epub 2018 Sep 23 doi: 10.1002/jum.14787. PMID: 30244477
Growth rate of vestibular schwannoma.
Paldor I, Chen AS, Kaye AH
J Clin Neurosci 2016 Oct;32:1-8. Epub 2016 Jul 20 doi: 10.1016/j.jocn.2016.05.003. PMID: 27450283
Hearing preservation: microsurgery.
Kari E, Friedman RA
Curr Opin Otolaryngol Head Neck Surg 2012 Oct;20(5):358-66. doi: 10.1097/MOO.0b013e3283579673. PMID: 22929113

Recent systematic reviews

Treatment for vestibular schwannoma: Systematic review and single arm meta-analysis.
Thai NLB, Mai NY, Vuong NL, Tin NM, Karam D, Refaey MA, Shahin KM, Soliman AL, Al Khudari R, Thuan TM, Sabbah GM, El-Qushayri AE, Karimzadeh S, Hirayama K, Huy NT
Am J Otolaryngol 2022 Mar-Apr;43(2):103337. Epub 2021 Dec 20 doi: 10.1016/j.amjoto.2021.103337. PMID: 34973662
Extracorporeal Shockwave Therapy for Foot and Ankle Disorders: A Systematic Review and Meta-Analysis.
Nazim B Tengku Yusof T, Seow D, Vig KS
J Am Podiatr Med Assoc 2022 May-Jun;112(3) doi: 10.7547/18-191. PMID: 34878537
Non-surgical treatments for Morton's neuroma: A systematic review.
Thomson L, Aujla RS, Divall P, Bhatia M
Foot Ankle Surg 2020 Oct;26(7):736-743. Epub 2019 Nov 2 doi: 10.1016/j.fas.2019.09.009. PMID: 31718949
The effectiveness of non-surgical interventions for common plantar digital compressive neuropathy (Morton's neuroma): a systematic review and meta-analysis.
Matthews BG, Hurn SE, Harding MP, Henry RA, Ware RS
J Foot Ankle Res 2019;12:12. Epub 2019 Feb 13 doi: 10.1186/s13047-019-0320-7. PMID: 30809275Free PMC Article
Treatment of Morton's neuroma: A systematic review.
Valisena S, Petri GJ, Ferrero A
Foot Ankle Surg 2018 Aug;24(4):271-281. Epub 2017 Apr 5 doi: 10.1016/j.fas.2017.03.010. PMID: 29409240

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